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PhytoPharmacon
PhytoPharmacon is listed as a small business research supplier in the Scientist.com network, with 3 sites in 1 country and 1 service area.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Antibodies
- Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
Biomarkers
- Adipogenesis Assay Detect and quantify intracellular triglyceride accumulation in adipocytes.
- Antimicrobial Effectiveness Testing Measure the efficacy of anti-microbial preservatives added to a product.
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
- Plaque Assays Determine infectious viral titer using plaque-forming units or purify viral stocks.
Cell Culture and Characterization
- Bacterial Cell Culture Culture and Grow bacterial cells.
- Cell Culture Culture primary or immortalized cell lines.
Chemical and Compound Analysis
- Natural Product Libraries Find microbial, botanical and marine sources of natural products.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Clinical Consulting
- Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...
Discovery Chemistry
- Natural Product Screening Screen large natural product collections for therapeutic activity.
Show all 56 services
In Vitro ADME
- Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
In Vitro Assays
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell Proliferation Measure cell number, cell viability and cell division.
- High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
Show all 11 in In Vitro Assays
- HTS Assay Development Develop assays to use in high throughput screening.
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
- Microbiology Study microbes and their role in human health.
- Reactive Species Assays Use biochemical, cell-based or in vivo assays to detect and evaluate the effects of reactive species.
- Virus Detection Assays Use ultra-sensitve methods to reliably detect low level viruses.
In Vitro Pharmacology
- Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
- Chloride Channel Assays Use biochemical, cell-based or in vivo assays to measure chloride channel activity.
- Dehydrogenase Assays Measure dehydrogenase activity in biochemical and cell-based assays.
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- Extracellular signal Regulated Kinase Assays Use biochemical, cell based or in vivo assays to measure ERK enzyme activity.
- Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.
Show all 27 in In Vitro Pharmacology
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- Histone Acetyltransferase (HAT) Assays Use biochemical, cell-based or in vivo assays to measure histone acetyltransferase activity.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
- Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
- Liposome Immunoassay Use immuno-liposomes for improved signal intensity and detection sensitivity compared to enzyme and fluorescent immunoassays.
- Methyltransferase Assays Use biochemical, cell-based or in vitro assays to measure methyltransferase activity.
- Nitric Oxide Synthase Assays Measure nitric oxide synthase activity by biochemical or cellular assays.
- Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
- Nucleoside Transporter Assays Use biochemical, cell-based or in vivo assays to measure nucleoside transporter activity.
- Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
- Peptide Transporter Assays Use biochemical, cell-based or in vivo assays to measure peptide transporter activity.
- Peroxidase Assays Measure peroxidase activity in bacterial and mammalian cells.
- Phosphatase Assays Use biochemical, cell-based or in vitro assays to measure phosphatase activity.
- Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
- Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
- Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
- Protease Assay Measure protease activity in biochemical and cell-based assays.
- Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
- Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
- Ubiquitin Ligase Assays Measure ligase enzyme activity in the presence of cofactors or chemical modifiers.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
Other Specialty Toxicology
- Microbial Testing Test samples for microorganisms, identify species, do bioburden analysis and measure endotoxin levels (LAL).
Personal Care
- Natural Products Find extracts from native living organisms with potential therapeutic effects.
Processing, Packaging, & Preservation
- Preservation and Antioxidant Testing Ensure the foods or dietary supplements are free of preservatives and antioxidants at a potentially harmful level.
Other services
- Natural Product Analysis Isolate and characterize active components of natural products.
Service areas:
Where it operates
Sites by country, with the cities in each.
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United States 3 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
High Throughput Screening PPI offers several solutions to address the problems and perform high-throughput screening assays. The company uses multiple cell line offerings that allow one to run a panel of counter screen assays for a desired target and incorporate studies of toxic receptors, as it is an inducible and titratable system. At PPI we are trying out an intensive parallel approach, where we apply a lot of resources upfront including assay development, screening more focused libraries. Our screening, assay development, and chemistry groups work hand in hand during this process...
Show the full description
High Throughput Screening
PPI offers several solutions to address the problems and perform high-throughput screening assays. The company uses multiple cell line offerings that allow one to run a panel of counter screen assays for a desired target and incorporate studies of toxic receptors, as it is an inducible and titratable system. At PPI we are trying out an intensive parallel approach, where we apply a lot of resources upfront including assay development, screening more focused libraries. Our screening, assay development, and chemistry groups work hand in hand during this process. The hope is to collapse the timeline and enable quicker lead decisions. An additional goal is to interpret compound effects from multiple assays that use diverse technologies to gain a comprehensive picture of a compound’s mode-of-action.
The unique automation available at PPI enables multiple screens to be efficiently carried out with a relatively small personnel team. A single screen team (one Sr. scientist and one Technician) is sufficient to run robotic system. Thus, this team would typically handle in the region of 40-50,000 assays per week including the high throughput screen, data analysis and initial lead follow-up (IC 50’s and cytotoxicity controls). Our system have been screened against the last five years in which over 250,000 compounds/extracts have been screened against several targets as part of our in-house and client’s drug discovery program.
- Professional associations
- NCBIO
- Website
- www.phytopharmacon.com
Work with PhytoPharmacon on Scientist.com
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