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AnaBios Corporation
AnaBios Corporation is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country and 3 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Biomarkers
- Human Primary Cell Isolation Isolate primary cells from various human tissues.
Cell Culture and Characterization
- Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Disease Models
- Pain Models Test therapeutic efficacy of drug candidate in pain model.
- Precision Cut Lung Slices (PCLS) Use a phenotypically accurate model of lung behavior for screening and target validation.
Human Biological Samples
- Biospecimen Finder Explore listings of Human Biological Samples from the suppliers on the scientist.com HBS database
- FRBESaHBS Request human biosamples including tissues, blood, serum, bone marrow, and tissue microarrays.
- HBS Healthy/Controls For requesting HBS Healthy/Controls
- HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
- Human Heart For requesting Human Heart Samples.
- Human Primary Cells Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely”...
Show all 7 in Human Biological Samples
- Human Whole Organs Procure non-transplantable whole human organs or tissues, healthy or diseased, for medical research and development.
In Vitro ADME
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Show all 33 services
In Vitro Assays
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Glycobiology Study the structure biosynthesis and biology of carbohydrates
In Vitro Pharmacology
- In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
- Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
- Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
- Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
In Vitro Toxicology
- Cardiac Channels Measure the arrhythmia producing potential of test compounds.
- Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
- Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
- Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
- Cytotoxicity Test for effects on cell viability and proliferation
- Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
Show all 8 in In Vitro Toxicology
- hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
- Perfused Heart Examine cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects.
Model Development
- Fresh Functional Human Tissue Efficacy Assays Use fresh functional human tissue to assess pre-clinical efficacy of test compounds.
- Fresh Functional Human Tissue Vasoconstriction Assays Use fresh functional human tissue to assess vasoconstriction with various compounds.
- Human Precision-Cut Lung Slice Model Acquire a fresh phenotypically-accurate model to study human lung behavior.
- Neuronal Electrophysiology Assays Study the electrical properties of biological cells and tissues in the nervous system.
Safety Pharmacology
- Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Other services
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
-
United States 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Technology Phase-X® is the proprietary technology developed by AnaBios which enables the investigation of human drug responses in the pre-clinical stage of drug development. In the past, access to human cells and tissues for research has relied, almost invariably, on samples collected employing inconsistent protocols, variable postmortem intervals and a lack of adequate reagents for ensuring sample viability. As a result of ischemic damage, most available samples were of poor quality and provided inconsistent results. It has also been difficult, if not impossible, to use human tissue...
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Technology
Phase-X® is the proprietary technology developed by AnaBios which enables the investigation of human drug responses in the pre-clinical stage of drug development.
In the past, access to human cells and tissues for research has relied, almost invariably, on samples collected employing inconsistent protocols, variable postmortem intervals and a lack of adequate reagents for ensuring sample viability. As a result of ischemic damage, most available samples were of poor quality and provided inconsistent results. It has also been difficult, if not impossible, to use human tissue samples reliably for functional biochemical and physiological testing of drug effects.
At the foundation of AnaBios' Phase-X® drug development platform are:
1- Proprietary methods and reagents for the consistent and reliable procurement of viable human donor samples
2- Proprietary methods and reagents for the preservation of human sample viability
3- Advanced in vitro interrogation methods for obtaining human-relevant data on drug activity.
Phase X® technology in drug discovery
Target identification / validation
Access to human tissue samples from both healthy as well as diseased donors allows for the discovery of novel molecular targets. The high quality of samples procured employing Phase X® technology enables the generation of highly reliable data profiling gene expression, proteomics, metabolomics and system biology parameters.
Small libraries screening on authentic human cellular targets
Early identification of human-relevant hit and lead compounds.
Lead optimization and clinical candidate selection
Phase X® ensures that lead optimization truly enhances drug safety and efficacy profiles in humans, not just in animal models. This strategy maximizes the chances that preclinical data will successfully translate during clinical development.
Clinical candidate selection based on human cell and tissue data, provides the best opportunity for successful clinical development and completely avoids the risks posed by species differences between animal models and human patient populations.
- Professional associations
- BIOCOM, SOT
- Website
- www.anabios.com
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