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PharmOptima
PharmOptima is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 2 service areas.
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Sites
1
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Antibodies
- Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Biomarkers
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Chemical and Compound Analysis
- Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
- GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Ion Exchange Chromatography Separate and detect analytes.
- Liquid Chromatography Separate substances using a mobile and stationary phase.
- Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Show all 11 in Chemical and Compound Analysis
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
- Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
- Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
Chemistry, Manufacturing and Controls (CMC)
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Clinical Trials
- Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Disease Models
- Diabetic Retinopathy Models Assess therapeutic efficacy of drug candidates in diabetic retinopathy models of disease.
- Dry Eye Models Measure therapeutic endpoints such as tear induction, TBUT, Schirmer strips (tear volume) and cornea staining.
- Macular Degeneration Models Use a single animal species to create one or more models for eye disease.
- Ocular Inflammation Models Measure ocular inflammation in models of eye disorders such as uveitis and keratitis.
- Ophthalmic Models Test drug candidates in glaucoma, macular degeneration, keratitis, uveitis and CMV retinitis models.
- Pigmented Rabbit Use a single animal species to create one or more disease models for eye cancer.
Show all 61 services
Drug Development
- Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
General in vivo Toxicology
- Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
- Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.
In Vitro ADME
- Cell Fractionation Isolate organelles and subcellular components.
- Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
- Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
- Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
- Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
In Vitro Assays
- Apoptotic Cell Staining Detect apoptotic cells in culture.
- Assay Development Construct or create new assays or modify existing ones.
- HTS Assay Development Develop assays to use in high throughput screening.
- Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
- Porcine Cornea Reversibility Assay (PorCORA) Measure corneal damage and recovery in excised porcine corneas.
In Vitro Pharmacology
- Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
- In Vitro Eye Models Measure cytokine production, cell viability, apoptosis and wound healing.
Show all 13 in In Vitro Pharmacology
- Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
- Protease Assay Measure protease activity in biochemical and cell-based assays.
- Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
- Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
- Substrate Competitive Study Determine whether or not a compound is competitive with a substrate.
- Target Identification Identify the target(s) of a biologically active substance.
- Time Dependent Study Determine whether or not a compound binds to an enzyme in a time-dependent manner.
In Vivo Pharmacokinetics
- In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
- Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
- Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
- Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
- Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
- Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Show all 7 in In Vivo Pharmacokinetics
- Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Protein Sciences
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Protein Binding Determine drug-protein binding interactions
- Protein Purification Isolate native or recombinant proteins from a sample.
Safety Pharmacology
- Tissue Cross Reactivity Assess the toxic effects of humanized monoclonal antibodies in 33 normal types recommended by the FDA.
Testing Services
- Ex Vivo Eye Irritation Test (EVEIT) Use optical coherence tomography (OCT) to monitor full-thickness recovery of corneal tissue.
Other services
- New Request
Service areas:
DMPK
Pharmacology
Where it operates
Sites by country, with the cities in each.
-
United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Preclinical CRO founded and operated by scientists with extensive big pharma experience. The company’s in vivo research services include delivery, efficacy, tolerance, pharmacokinetics and ADME. Our in vitro expertise includes biochemistry, recombinant proteins: cloning and expression, cell-based assays, immunosorbent assays (traditional ELISA and electrochemiluminescence MSD formats) and biomarker research. PharmOptima is recognized as a leading CRO conducting ocular research as well as the premier provider of Spinal Muscular Atrophy research.
- Website
- www.pharmoptima.com
Work with PharmOptima on Scientist.com
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