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ProNovus Bioscience, LLC
ProNovus Bioscience, LLC is listed as a new startup research supplier in the Scientist.com network, with 2 sites in 1 country and 1 service area.
View ProNovus Bioscience, LLC on Scientist.com
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Sites
2
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: New startup
Antibodies
- Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
- Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
- Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
- Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
- Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.
- In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Show all 7 in Antibodies
- Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.
Biomarkers
- Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
- Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
- Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Show all 10 in Biomarkers
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
- Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
- Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Show all 80 services
Cell Culture and Characterization
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Bacterial Cell Culture Culture and Grow bacterial cells.
- Cell Culture Culture primary or immortalized cell lines.
- Cell Line Construction Create new recombinant cell lines to exact specifications.
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
- Insect Tissue Culture Grow insect cells.
Show all 7 in Cell Culture and Characterization
- Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Chemical and Compound Analysis
- Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
- Ion Exchange Chromatography Separate and detect analytes.
- Protein Crystallization Create high quality protein-ligand crystals for x-ray diffraction studies.
- Protein Melting Point Analysis Assess protein stability by Differential Scanning Calorimetry (DSC) or Fluorimetry (Thermofluor) methods.
- Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Chemistry, Manufacturing and Controls (CMC)
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Discovery Chemistry
- Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
DNA & RNA
- DNA Extraction Extract DNA from an original source.
- DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
- DNA Products Find DNA products including gDNA, cDNA clones, vectors and constructs from mice, insects, yeast, bacteria and viruses.
- Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
- mRNA synthesis Transcribe mRNAs in vitro and add modifications such as polyadenylation and guanine capping.
- Nucleic Acid Hybridization Use a nucleic acid probe to identify complementary sequences.
Show all 12 in DNA & RNA
- PCR Mutagenesis Use polymerase chain reaction to create mutations in a cloned gene.
- Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
- qPCR Analysis Measure the accumulation of PCR products in real time.
- Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
- RNA Extraction Isolate total RNA or mRNA from cells or tissues
- RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
In Vitro ADME
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
In Vitro Assays
- Assay Development Construct or create new assays or modify existing ones.
- Cell Proliferation Measure cell number, cell viability and cell division.
- Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
In Vitro Pharmacology
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- Peptide Transporter Assays Use biochemical, cell-based or in vivo assays to measure peptide transporter activity.
- Solute-Linked Carrier (SLC) Transporter Inhibition Assays Use biochemical, cell-based or in vivo assays to measure solute-linked carrier transporter activity.
- Solute-Linked Carrier (SLC) Transporter Substrate Identification Use biochemical, cell-based or in vivo assays to identify solute-linked carrier transporter substrates.
- Target Identification Identify the target(s) of a biologically active substance.
In Vitro Toxicology
- ADCC and CDC Assay Services Measure toxicity of antibodies.
- Cytotoxicity Test for effects on cell viability and proliferation
In Vivo ADME
- Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
- Quantitative Whole Body Autoradiography (QWBA) Determine the tissue distribution of a radiolabeled compound in Rodent and Non-Rodent Species.
- Quantitative Whole Body Autoradiography (QWBA) - Non-rodent Species Conduct a study to determine the tissue distribution of your compound radiolabeled compound in non-rodent species.
Product Orders
- Kits and Reagents Submit a request to multiple vendors for kits and reagents.
Protein Sciences
- Affinity Tag Purification Purify proteins under physiological conditions at their native cellular levels.
- Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Fluorophore Protein Conjugation Attach a fluorescent probe to a protein.
- Fusion Proteins Use recombinant DNA technology to create and express proteins derived from more than one gene.
- Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
Show all 18 in Protein Sciences
- Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
- Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
- NanoBRET™ Technology Measure real-time protein interactions in living cells.
- Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
- Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
- Protein Products Find native and recombinant proteins and peptides.
- Protein Purification Isolate native or recombinant proteins from a sample.
- Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
- Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
- Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
- Virus Production Produce high titer viruses, viral expression vectors and vaccines.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Other services
- New Request
Service areas:
Biology
Where it operates
Sites by country, with the cities in each.
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United States 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
ProNovus Bioscience provides services in RNA/DNA purification, gene cloning, qPCR, site-directed mutagenesis, protein expression and protein purification. We specialize in the expression and characterization of membrane proteins such as drug transporters and GPCRs using baculoviral expression. ProNovus Bioscience was founded by bench scientists with the goal of combining their 30+ years of experience in membrane protein biology research to provide the scientific community with valuable reagents. With expertise in the molecular, structural and functional aspects of membrane proteins...
Show the full description
ProNovus Bioscience provides services in RNA/DNA purification, gene cloning, qPCR, site-directed mutagenesis, protein expression and protein purification. We specialize in the expression and characterization of membrane proteins such as drug transporters and GPCRs using baculoviral expression.
ProNovus Bioscience was founded by bench scientists with the goal of combining their 30+ years of experience in membrane protein biology research to provide the scientific community with valuable reagents. With expertise in the molecular, structural and functional aspects of membrane proteins, ProNovus Bioscience seeks to open and advance opportunities in basic research and drug development targeting and/or affecting G protein-coupled receptors and ABC and SLC transporters.
- Website
- www.pronovusbio.com
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