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BRI Biopharmaceutical Research
BRI Biopharmaceutical Research is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 2 service areas.
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Sites
1
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Biomarkers
- Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
- Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
- Microbiome Services Examine the community of commensal, symbiotic, and pathogenic microorganisms that make up the microbiome.
- NBE Biomarkers Request information or a price quote for NBE Biomarkers services
- Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Chemical and Compound Analysis
- Chemical Stability Measure the stability of small molecules in solution.
- Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
- GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Show all 8 in Chemical and Compound Analysis
- Process Residual Impurities Detection Measure trace levels of impurities.
- Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Chemistry, Manufacturing and Controls (CMC)
- API and Drug Product Stability Testing API and Drug Product Stability Testing.
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
- Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
- Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
Show all 41 services
Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
DNA & RNA
- Gene/Oligo Synthesis Synthesize oligonucleotide or gene for microarrays, RT-PCR and PCR cloning.
Drug Metabolism and Pharmacokinetics (DMPK)
- Biomarkers DMPK Biomarker DMPK and gene analysis services are critical tools in evaluating patients and discovery of new therapeutics.
In Vitro ADME
- Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
- Equilibrium Dialysis Measure the extent of binding of drugs to plasma proteins.
- GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
Show all 15 in In Vitro ADME
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
- No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
- Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
In Vivo ADME
- Chronic Bile Duct Cannulation (BDC) Study - Other Species Conduct a bile duct cannulation (BDC) study in other species to support the absorption, distribution, metabolism and excretion profiling of your compound.
In Vivo Pharmacokinetics
- Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Oncology Models
- Renal Xenograft Measure therapeutic endpoints in renal models of cancer.
- Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.
Protein Sciences
- Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Service areas:
Biology
DMPK
Where it operates
Sites by country, with the cities in each.
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Canada 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
BRI Biopharmaceutical Research offers small molecule drug assays, biomarkers, drug metabolism, CMC studies, bioanalytical services, and rodent models.
- Professional associations
- AAPS, BayBio, WBBA
- Website
- www.frontagelab.com
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