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UMass Chan Medical School – Research Cores
UMass Chan Medical School – Research Cores is listed as an academic core research supplier in the Scientist.com network, with 1 site in 1 country.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Academic core
Bioimaging
- Bioimaging Visualize biological process non-invasively in real time.
- Cryo Electron Microscopy Examine the 3D structure of biological complexes and organelles.
- Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
- In Vivo Imaging In-vivo imaging using PET, MRI, CT etc.
- In Vivo Whole Tissue and Animal Imaging Analysis Analysis of images from in vivo studies produced using PET, MRI, CT, etc. in a variety of species.
- Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.
Show all 11 in Bioimaging
- Magnetic Resonance Imaging Use MRI to obtain chemical and physical information about molecules and map the internal structure of an object.
- Mass Spectrometry Imaging Visualize the spatial distribution of molecules, as biomarkers, metabolites, peptides or proteins by their molecular masses
- Medical Imaging Visualize and analyze internal structures in animal models or patients.
- Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
- Scanning Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
Biomarkers
- Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
- Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
- Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Cell Membrane Lipidomics Study the pathways and networks of membrane lipids.
- Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Show all 19 in Biomarkers
- Digital Biomarkers Objective, quantifiable physiological and behavioral data that are collected and measured by means of digital devices such as portables, wearables, implantables, or digestibles.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
- Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
- Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
- Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
- Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
- Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
- Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
- Protein Glycosylation Mapping Technique Map glycosylation sites in proteins using liquid chromatography and mass spectrometry.
- Spatial Metabolomics The study of the spatial distribution and localization of metabolites within biological tissues using advanced imaging and analytical techniques.
Show all 106 services
Cell Culture and Characterization
- Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
- Cell Sorting The purpose of cell separation is to isolate a cell population from other cells in a biological sample.
- Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.
- H & E Services For requesting services related to H&E Services
- Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
- Resin-based Histology Perform sectioning and histological analysis of epoxy/acrylic/polycarbonate-embedded samples.
Show all 8 in Cell Culture and Characterization
- Single Cell Services Request services to perform genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level
- Trichrome Staining Use a variety of techniques for the selective visualization of muscle, collagen fibers, fibrin and erythrocytes.
Chemical and Compound Analysis
- Computed Tomography Visualize the internal features of solid objects.
- Light Sheet Fluorescence Microscopy Use a planar sheet of light to section transparent tissues and generate a 3D image.
- NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
- NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
- Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
- Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Show all 12 in Chemical and Compound Analysis
- Scanning and Transmission Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
- Solid State Nuclear Magnetic Resonance Identify molecular structure or impurities and assess product integrity of solid samples.
- Solution Nuclear Magnetic Resonance Identify molecular structure or impurities and assess product integrity of solution samples.
- Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.
- Ultrasound Tomography Use the transmission and acquisition of ultrasound waves to create a non-invasive technique for imaging.
- X-ray Microscopy and Nanotomography (Nano-CT) Create two- and three-dimensional imaging of objects in real time.
Chemistry, Manufacturing and Controls (CMC)
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Disease Models
- Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
- Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
- Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
- Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
- General Pain Models Measure therapeutic endpoints in animal models of general pain.
- Ischemia Models Measure therapeutic endpoints in animal models of ischemia.
Show all 13 in Disease Models
- Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
- Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
- Microsurgery in Rodents Outsource microsurgeries projects required for testing new therapies on a rodent model.
- Ob/ob Mouse Use a single animal species to create one or more disease models obesity and angiogenesis.
- Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
- Stroke Models Measure therapeutic endpoints in animal models of stroke.
- Thrombosis Models Measure therapeutic endpoints in animal models of thrombosis.
DNA & RNA
- Amplicon - HLA Typing Use an amplicon sequencing method to identify allelic variation within the HLA genes.
- Amplicon 16s rRNA Sequencing Identify and compare bacteria present within a given sample.
- ChIP-Sequencing Use chromosome immunoprecipitation to identify DNA-protein binding sites in a genome.
- ChIP-sequencing Profiling Identify where a protein is binding to DNA on a genome-wide scale.
- Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
- Sequence Based Methylation Analysis Detect DNA methylation sites within cytosine-phosphate-guanine (CpG) dinucleotides at single base-pair resolution.
Show all 7 in DNA & RNA
- Targeted Sequencing/Resequencing Detect variations in a genome subset.
In Vitro ADME
- Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
In Vitro Assays
- Assay Development Construct or create new assays or modify existing ones.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro Pharmacology
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
- In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Toxicology
- Perfused Heart Examine cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects.
In Vivo Pharmacokinetics
- Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Model Development
- Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
- Custom Model Development Develop a custom disease model.
- Pulmonary Hypertension Animal Model Study the pathology of pulmonary arterial hypertension (PAH) and investigate potential therapies.
- Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
- Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.
New Product Development
- Quantitative Descriptive Food Analysis Apply a variety of methods to quantify the sensory properties of distinct product attributes.
Oncology Models
- Animal Hypoxia Models Measure therapeutic endpoints in hypoxic animal models.
Protein Sciences
- Adeno Associated Virus (AAV) Production Clone into AAV expression vectors and produce high titer viruses.
- Integrated Proteomics Package Process an entire Proteomics Pipeline Project including: Sample Preparation, Target Enrichment, NGS Instrumentation, and Data Analysis from our Bundle of Suppliers
- LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
- Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
- NMR Determine molecular and protein structure, and validate sample integrity.
- Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Show all 12 in Protein Sciences
- Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
- Protein mapping Interrogate the entire sequence of a protein.
- Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
- Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
- Quantitative MS Quantify small and large molecules in the pg/ml range
- X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.
Scientific Data Services
- High-Performance Computing Compute using higher performing parallel processing.
- Metabolomics Data Analysis Use metabolites to identify any potential biomarkers or novel therapeutic targets that may play a role in the mechanisms responsible for the progression of a disease.
- Scientific Data Visualization Exploration and reporting of data by means of graphs and plots.
- Systems Network Analysis Analyze and visualize molecular pathways including gene regulatory, protein-protein and drug-target networks.
Other services
- New Request
Where it operates
Sites by country, with the cities in each.
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Services include conventional fixation and sectioning of cells and tissues, negative staining of organelles and macromolecular assemblies, shadowing of isolated protein molecules, freeze-fracture, immunolabeling, etc.
Cryo-sectioning and cryo-electron microscopy are also available. Expert consultation on all aspects of experimental planning and micrograph interpretation is provided by the facility manager, Greg Hendricks.
- Website
- www.umassmed.edu/research/cores
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