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Crown Bioscience, Inc.

Crown Bioscience, Inc. is listed as a large business research supplier in the Scientist.com network, with 13 sites in 7 countries and 4 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 13

Countries 7

Type of company: Large business

Agricultural Sciences Research & Development

DNA/Protein analysis Analyze DNA and proteins for allergens, pathogens and species identification.
Gene Isolation and cloning Development of methods for isolation of gene(s) of interest.
Method Development & Validation Engineer sensitive and selective methods that meet GLP validation requirements to access different agrochemical properties

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
Antibody Protein De Novo Sequencing Sequence antibody proteins using multiple enzyme digestion and high-resolution LC-MS/MS.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
Custom Antibodies Design and produce polyclonal and monoclonal antibodies.

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Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.
In Silico Humanization Predict epitope binding specificity, increase in vivo half-life and allow rapid modeling and humanization of antibodies.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.

Bioimaging

Bioimaging Visualize biological process non-invasively in real time.
In Vivo Imaging In-vivo imaging using PET, MRI, CT etc.
In Vivo Positron Emission Tomography (PET) Imaging Image tumor progression or conduct biodistribution investigations in experimental animals injected with a radiolabeled molecular probe.
In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.
In Vivo Whole Tissue and Animal Imaging Analysis Analysis of images from in vivo studies produced using PET, MRI, CT, etc. in a variety of species.
Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.

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Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
Positron Emission Tomography (PET) Imaging Use PET imaging with radioactive agent to visualize and measure metabolic processes in the body.
SPECT-CT and PET-CT Imaging Get images that combine the spatial context of metabolic or biochemical activity with an anatomic image.

Show all 429 services 414 more

Biomarkers

Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body

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Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Cerebrospinal Fluid Analysis Use CSF to detect or monitor a variety of nervous system diseases or conditions.
Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Complete Blood Count Set of medical laboratory tests that provide information about the cells in blood.
Complete Metabolic Panel Testing Detect electrolyte or glucose imbalance to identify or monitor related disorders.
Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
Cytogenetics Examine the structure and function of the cell, especially chromosomes.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.
Endocrine Assays Use biochemical, cell based or in vivo assays to measure the concentration of hormones.
Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Fluorescent In Situ Hybridization Use FISH to identify abnormal chromosome structures and to quantify specific DNA sequences.
Genomics Genomic services including applications to DNA (*sanger sequencing, whole genome amplification, library screening, cloning, sub-cloning, and DNA isolation*) and RNA (*microRNA analysis, RNA isolation, qRT-PCR, mRNA...
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Human Primary Cell Isolation Isolate primary cells from various human tissues.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
Lipid Peroxidation Assay Use in vitro or in vivo assays to evaluate the effects of oxidative stress on lipid structure and function.
Lipid Profiling Use quantitative analysis of blood lipid components to assess cardiac risk.
Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
Microbiome Services Examine the community of commensal, symbiotic, and pathogenic microorganisms that make up the microbiome.
Microfluidics-Based Biomarker Isolation and Detection Isolate and detect rare biomarkers in blood samples, such as CTCs, cfDNA, and exosomes.
Multiplex Circulating miRNA Assay Profile miRNAs directly from just 10 μl of crude biofluid or 0.1 ng of purified RNA.
Myeloperoxidase Testing Detect inflammatory markers and determine the risk for atherosclerosis or arterial plaque rupturing.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Peptide Bioanalysis Analyze the structure of Peptides.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Platelet Function Testing Evaluate complete platelet function in vivo or in vitro.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Propidium Iodide FACS Analysis Use DNA staining and flow cytometry to analyze the cell cycle and detect apoptosis or cell proliferation.
Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
Single Cell Isolation Isolate single cells for subsequent single-cell analysis.
Single Cell quantitative Real Time-PCR Assess gene expression levels and patterns in a single cell.
Single Cell Transcriptome Sequencing Detect distinct, rare or abnomal cell types in a heterogenous population.
Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Solid Tumor CDx Design and validate companion diagnostics for solid tumors that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Special Stainings Use a variety of techniques for the selective visualization of specific tissue or cell types.
Whole Transcriptome Amplification Amplify total RNA from a single cell.

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Authentication Verify the identity and purity of an experimental cell line or industrial culture.
Cell Sorting The purpose of cell separation is to isolate a cell population from other cells in a biological sample.

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Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.
Custom 3D Microtissue Development Convert cell lines into highly functional 3D microtissues using scaffold-free self-assembly.
Explant Culture Culture cells obtained from a part or parts of an in vivo structure.
H & E Services For requesting services related to H&E Services
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
In Vitro Hydrogel-Based Culture of PDXs Enable the extended laboratory culture of cancer PDXs and other primary cells in 3D.
RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
Single Cell DNA Sequencing Examine genetic variations in a single cell.
Single Cell Services Request services to perform genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level
STR Profiling - Microsatellite Short Tandem Repeat Confirm cell line identity and detect cross-contamination.
Viral Mediated Gene Delivery Use viral carriers to introduce new genetic material into a cell.

Chemical and Compound Analysis

Accelerator Mass Spectrometry Detect trace levels of naturally-occurring radionuclides and stable nuclides.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Computed Tomography Visualize the internal features of solid objects.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.

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Liquid Chromatography Separate substances using a mobile and stationary phase.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Optical Tomographic Imaging Use multiply-scattered light to reconstruct images of illuminated objects.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Structural Chemistry Examine the relationship between protein structure and function.
Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.

Chemistry, Manufacturing and Controls (CMC)

Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services

Clinical Consulting

Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
Biostatistics Consulting Apply statistical theory and mathematical principals to research

Clinical Trials

Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.
Phase 1-3 Studies Design phase 1-3 studies that seek to identify if a drug is safe, effective, and more efficient than other available treatments on the market.
Prospective Explorative Studies Conduct a prospective exploratory study to assess the safety and efficacy of a test drug during clinical trials.
Recruiting Healthy Volunteers Recruit volunteers who have no known significant health problems, and is willing and consenting to participate in research to test a new drug, device, or intervention.
Study/Site Feasibility Study Explore and test study practicality.

Companion Diagnostics

Cervical Cancer CDx Design and validate companion diagnostics for cervical cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Pancreatic Cancer CDx Design and validate companion diagnostics for pancreatic cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.

Data Science/Bioinformatics

Biostatistical Design Use statistics to ensure appropriate pre-clinical and clinical study design.
Clinical Biomarker Analysis An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
Discovery Biomarker Analytics An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
Discovery Data Management A process that includes acquiring, validating, storing, protecting, and processing required data to ensure the accessibility, reliability, and timeliness of the data for its users.
In Silico Cancer Genomics/Cancer Transcriptomics Analysis Interpret DNA sequencing and microarray data for cancer studies.
In Silico Epigenetic Compound Library Screening Use computer-aided methods to discover new compounds against key regulators of epigenetic signaling.

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Translational Biomarker Discovery An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.

Discovery Chemistry

LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Target-Focused Compound Libraries Find activity-based libraries directed towards a protein or cell signaling target.

Disease Models

Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
Auto-immune Hepatitis Models Measure therapeutic endpoints in animal models with auto-immune hepatitis.
Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.

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Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
Diabetic Retinopathy Models Assess therapeutic efficacy of drug candidates in diabetic retinopathy models of disease.
General Pain Models Measure therapeutic endpoints in animal models of general pain.
In Vivo Physiologic Monitoring Monitor and collect data from conscious, freely moving laboratory animals.
In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
Irritant Models Measure therapeutic endpoints in animal models of skin irritation.
Kidney Transplant Models Measure therapeutic endpoints in kidney transplant models.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
Microbiome-Based Skin Disease Technology Modify the skin microbiome and deliver therapeutic proteins to the target.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Ob/ob Mouse Use a single animal species to create one or more disease models obesity and angiogenesis.
Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Obese Primates Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Receptor Occupancy Models Determine the effective dose and concentration needed to reach effective levels in a given tissue.
Skin Graft Models Measure therapeutic endpoints in animal models of skin grafts.
Systemic Lupus Erythematosus Models Measure therapeutic endpoints in animal models of immune disorders such as SLE and lupus.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.
Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

Amplicon 16s rRNA Sequencing Identify and compare bacteria present within a given sample.
Bisulfite Seq DNA Methylation Analysis Determine DNA methylation status at single-base resolution
cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
cDNA library construction Generate a library of recombinant cDNA clones.
Cell Free DNA Assay Detect known mutations and discover new ones in cell-free plasma DNA.
ChIP-Sequencing Use chromosome immunoprecipitation to identify DNA-protein binding sites in a genome.

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ChIP-sequencing Profiling Identify where a protein is binding to DNA on a genome-wide scale.
CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
ddPCR-Based Plasma Genotyping Perform noninvasive tumor genotyping.
De Novo Genome Sequencing Determine the DNA sequence of uncharacterized genomes.
De Novo Transcriptome Sequencing Identify new genes without the need for a reference genome sequence.
Digital Polymerase Chain Reaction Obtain improved absolute target quantification and rare allele detection compared to conventional qPCR.
DNA Extraction Extract DNA from an original source.
DNA Hydroxy Methylation Seq Use epigenetic services to analyze genome-wide DNA hydroxymethylation.
DNA Library Screening Screen genomic or cDNA libraries for positive clones.
DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
DNA Products Find DNA products including gDNA, cDNA clones, vectors and constructs from mice, insects, yeast, bacteria and viruses.
DNA Reagents Request information or a price quote for DNA Reagents services
DNA Sequencing Determine the nucleotide sequence of DNA samples.
DNA Synthesis Produce DNA fragments for microarrays, PCR, cloning and expression studies.
DNA/RNA Extraction & Purification DNA/RNA Extraction & Purification.
Exome Sequencing Determine protein-coding nucleotide sequences in a DNA sample.
Gene/Oligo Synthesis Synthesize oligonucleotide or gene for microarrays, RT-PCR and PCR cloning.
Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
Genomic DNA cloning Clone and propagate genomic DNA inserts of 5-50kb.
Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
Knockout/Knockin Cell Lines Develop Knockout/Knockin Cell Line.
Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
mtDNA Sequencing Use next-generation sequencing (NGS) technology to detect and analyze mitochondrial mutations.
Nanostring nCounter Use single molecule imaging to count molecules directly and without enzymatic amplification.
NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
Non-Bisulfite DNA Methylation Analysis Analyze DNA methylation by methods such as differential enzymatic cleavage or affinity capture
Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Amplification Produce RNA from pre-clinical and clinical samples for use in gene expression studies.
RNA Extraction Isolate total RNA or mRNA from cells or tissues
RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
RNA oligo synthesis Design and synthesize miRNAs, siRNAs and other non coding RNAs
RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
RNA Reagents Request information or a price quote for RNA Reagents services
RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNAi Pathway Analysis Use high-throughput RNAi genetic screens to elucidate relevant signaling pathways.
Sanger Sequencing Sequence single strand DNA fragments using DNA Polymerase.
Sequence Based Methylation Analysis Detect DNA methylation sites within cytosine-phosphate-guanine (CpG) dinucleotides at single base-pair resolution.
shRNA Synthesis Design shRNA constructs that produce stable knockdown of the corresponding mRNA.
Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
siRNA Synthesis Produce high quality siRNAs for gene silencing studies.
SNP Characterization Identify single nucleotide polymorphisms to make genetic associations, analyze disease SNPs and determine LOH.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Targeted Sequencing/Resequencing Detect variations in a genome subset.
TCR Repertoire Sequencing Analyze the T cell receptor repertoire by means of next-generation sequencing.
Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.
Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.
Transcriptome Transfer (TIPeR) Use TIPeR method for converting one type of cell into another, by transfection with RNA reflecting the target cell type transcriptome.
Whole Genome Amplification (WGA) Amplify an entire genome from a single cell.
Whole Genome Bisulphite Seq Profile genome-wide DNA methylation.
Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.
Whole Genome Sequencing Determine the entire genetic make-up of an organism.

Drug Development

Bioinformatics Consulting Consulting Services for the science of collecting and analyzing complex biological data
Consulting Services Work with consultants who provide expert advice in various areas of research and technology.
Pharmacology Consulting Request consulting services related to pharmacology and the chemical properties, biological effects, and therapeutic uses of drugs.
Small Molecule Drug Development Consulting Request consulting services related to small molecule development.
Target Validation Consulting Help to demonstrate that modification of target activity has potential therapeutic benefits.
Toxicology Consulting Use models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

Drug Metabolism and Pharmacokinetics (DMPK)

Biomarkers DMPK Biomarker DMPK and gene analysis services are critical tools in evaluating patients and discovery of new therapeutics.

Effectiveness

Laboratory Dose Determination Studies Compare the effectiveness of three non-zero therapeutic concentrations for various durations to a non-medicated control group, and a non-medicated uninfected control group.

Food Safety & Regulations

Total Viable Count (TVC) Estimate the total living microbial populations present in a food or beverage sample to guarantee product quality.

General in vivo Toxicology

Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
IV Toxicology Test the toxicological effect of IV delivery of drug candidate.
Repeat Dose Toxicity Study - Monkey / Non-human Primate Conduct a repeat dose study in monkey/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Toxicity Study - Monkey / Non-human Primate Conduct a single dose study in Monkeys and Non-human Primates to determine the toxicokinetic behavior of your compound.
Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.

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Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.

Human Biological Samples

Biospecimen Finder Explore listings of Human Biological Samples from the suppliers on the scientist.com HBS database
Cell Line and Cellular Services Promotion for Cells and Cell lines
Custom FFPE cell line blocks Custom IHC compatible FFPE cell line blocks and sections
Custom PDX models For requesting Custom PDX models
Existing PDX models For requesting Existing PDX models
HBS Leukemia For requesting HBS Leukemia

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HBS Oncology For requesting Human biospecimens from Oncology indications
HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
Human Adult Stem Cells Acquire human stem cells isolated from various adult tissues.
Human Biofluids Acquire fresh/frozen biofluids based on patient demographics, disease stage, history and treatment.
Human Cerebral Spinal Fluid (CSF) Acquire fresh/frozen normal cerebrospinal fluid based on patient demographics and history.
Human DNA & RNA Acquire fresh/frozen Human DNA & RNA based on patient demographics, disease stage, treatment and history
Human Fixed Tissue Acquire Human fixed tissue based on patient demographics, disease stage, history and treatment.
Human Fresh Tissue For requesting fresh human tissue
Human Frozen Tissue For requesting frozen human tissue.
Human Immortalized Cell Culture For requesting human cells Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have been isolated from fresh tissue (or cultures) that...
Human Organoids Test immuno-oncology drugs and therapies on fresh, unpropagated 3D tumor organoids to evaluate efficacy and understand drug mechanism of action. Understand the intact tumor immune microenvironment, cytotoxic efficacy...
Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
Human Plasma Acquire fresh/frozen human plasma
Human Serum Acquire fresh/frozen normal serum based on patient demographics and history.
Human TMA For requesting Human Tissue MicroArrays
Human Urine Acquire fresh/frozen normal urine based on patient demographics and history.
Tissue Acquisition Find primary animal and human tissues and cells.

In Vitro ADME

Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.

In Vitro Assays

3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
3Screen™ 3D In Vitro Services 3Screen™ Platform enables complete 3D cell culture characterization.
Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.

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BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
ELISpot Assay and Testing Detect low levels of antigens.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
Glycobiology Study the structure biosynthesis and biology of carbohydrates
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
HTS Assay Development Develop assays to use in high throughput screening.
Human Custom TMA For requesting Human Custom Microarray Services
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
Microbiology Study microbes and their role in human health.
Organoid Screening Assay Evaluate the effects of various substances, such as drugs or genetic modifications, on organoids.
Pathogen Assays Detect and distinguish viral, bacteria and fungal strains and species.
Pathology Services Pathology Services
Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
Virus Detection Assays Use ultra-sensitve methods to reliably detect low level viruses.

In Vitro Pharmacology

Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
Fibroblast Growth Factor Receptor (FGFR) Assays Use biochemical, cell based or in vivo assays to measure FGF receptor activity.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
HuGEMM - Immuno-Oncology Model Evaluate human-specific therapeutics for checkpoint inhibitors, including anti-human PD-1, anti-human PDL-1, and anti-human CTLA-4 antibodies.
Human Epidermal growth factor Receptor (HER) Assays Use biochemical, cell based or in vivo assays to measure HER receptor activity.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.

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Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Protein/Enzyme Targets For requesting Protein/Enzyme Targets
Target Characterization Characterize potential drug targets during the drug discovery process.
Target Identification Identify the target(s) of a biologically active substance.
Ubiquitin Ligase Assays Measure ligase enzyme activity in the presence of cofactors or chemical modifiers.
Vascular Endothelial Growth Factor Receptor (VEGFR) Assays Use biochemical, cell based or in vivo assays to measure VEGF receptor activity.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cytotoxicity Test for effects on cell viability and proliferation
Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
Genotoxicity Evaluate potential of a compound to cause mutations and chromosomal aberations
Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
HepaRG Cells Obtain terminally differentiated and cryopreserved hepatic cells that retain many characteristics of primary human hepatocytes.

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Tubule Epithelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the kidney.

In Vivo ADME

Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
Quantitative Whole Body Autoradiography (QWBA) Determine the tissue distribution of a radiolabeled compound in Rodent and Non-Rodent Species.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.

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Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Lab Supplies, Facilities, and Equipment

Biobanking Store and track biological samples.

Management Optimization & Development Strategies

Big Data Computational assistance with analysis of large data sets to reveal patterns, trends and associations

Medical Communications

Data Visualization Visualize data collected from clinical trials and/or clinical research.
Pharmacodynamic/ Pharmacokinetic Reports Create Pharmacodynamic/ Pharmacokinetic reports to report to the appropriate regulatory bodies.
Protocol and Study Reports Write protocol and study reports, specifically relating to the drafting, writing, and editing of Clinical Safety Reports.

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Custom Model Development Develop a custom disease model.
Human Precision-Cut Intestinal Slice Model Acquire a fresh phenotypically-accurate model to study human intestinal behavior.
Human Precision-Cut Liver Slice Model Acquire a fresh phenotypically-accurate model to study human liver behavior.
In Silico PK-PD Modeling Quantitative modeling and simulations correlation of pharmacokinetic and pharmacodynamic endpoints in support of preclinical and clinical development.
Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.

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Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.
NMRI Mouse Use a single animal species to create one or more disease models for cachexia and hemophilia.
Non-Human Primate Models Use a single animal species to create one or more disease models.
PBMC Humanized Mice Study and evaluate compounds for infectious diseases and graft rejection.
SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.
Zucker Rat Use a single animal species to create one or more disease models for cachexia.

Non-Human Biospecimen

Monkey / Non-Human Primate / NHP Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Mouse Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.

Oncology Models

Athymic Mouse Use a single animal species to create one or more disease models for cachexia and spontaneous cancer.
CAR-T Efficacy In Vivo assessment of CAR-T and CAR-NK efficacy in a humanized mouse
Digestive System PDX Patient derived xenografts relating to organs and components of the digestive system. This includes, but is not limited to the Stomach, Intestines, Liver, Colon, Colorectal samples and Gastric samples.
Endocrine System PDX Patient derived xenografts related to the endocrine system. PDX related to glands controlling hormone regulation such as the Pituitary glands, Thyroid Glands, Adrenals, and Pancreas.
Endocrine System Xenograft Xenografts derived from organs and glands of the Endocrine system. This include samples from the Pituitary Gland, Thyroid, and Adrenals.
Ex-Vivo PDX Screening Ex-vivo PDX screening is used to evaluate the effectiveness of various drugs on tumor cells.

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Hematological Cancer PDX Design and validate companion diagnostics for hematological cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Immuno-PDX Utilize the patient-derived xenograft for drug response profiling and biomarker discovery of immuno-oncology drug candidates.
Leukemia PDX Measure therapeutic endpoints in patient-derived xenografts of leukemia.
Lung PDX Measure therapeutic endpoints in patient-derived xenografts of pulmonary cancer.
Murine Adenocarcinoma 16 (MAC16) Murine Test for therapeutic efficacy of drug candidates in muscle wasting models.
Nervous System Xenografts Xenografts relating to the Nervous system. This includes samples from the Head, Neck, Brain, and Nerves.
Oncology Derived PDX Patient derived xenografts derived from various oncological samples. This includes, but is not limited to, samples from Lymphoma, Melanoma, and Leukemia.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Oncology Xenografts Xenografts derived from oncological samples.
Oral Xenograft Measure therapeutic endpoints in oral cancer models as well as cancer models related to the Pharynx.
Ovarian Cancer Mouse Measure therapeutic endpoints in animal models of ovarian cancer.
Renal Xenograft Measure therapeutic endpoints in renal models of cancer.
Reproductive System PDX Patient derived xenografts relating to reproductive systems. This includes PDX from reproductive organs such as the Ovaries, Cervix, Breasts, Testes, Prostate, and Scrotum.
Reproductive System Xenografts Xenografts relating and derived from the reproductive systems. This includes samples from the ovaries, cervix, vulva, uterus, testes, scrotum, and prostate.
Sarcoma PDX Measure therapeutic endpoints in patient-derived xenografts of sarcoma.
T11 (Breast Cancer) Measure therapeutic endpoints in animal models of breast cancer.
Urinary System PDX Patient Derived Xenografts relating to organs that comprise the Urinary system. This includes, but is not limited to, samples from the Kidneys, Liver, and Bladder.
Urinary System Xenografts Xenografts derived from organs of the Urinary system. This includes, but is not limited to, xenografts from the Bladder, Kidney, and Urethra.
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Other Specialty Toxicology

Microbial Testing Test samples for microorganisms, identify species, do bioburden analysis and measure endotoxin levels (LAL).
Residual DNA Analysis Measure contaminants found in therapeutics like biologicals and biosimilars that are produced in cells.

Pharmacology

In Vivo Pharmacology Study the effects of drug candidates in animal models

Protein Sciences

Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Lentivirus Production Develop lentiviruses and production protocols.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.

Show all 23 in Protein Sciences 17 more

Peptide Array Use biologically active synthetic peptides arranged in a high density format to assess protein interaction.
Phage Display Use in vitro screening method to identify protein binding partners.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Protein Chemistry Request information or a price quote for Protein Chemistry services
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Identification Uncover or confirm the identity of a protein.
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Protein mapping Interrogate the entire sequence of a protein.
Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Protein Products Find native and recombinant proteins and peptides.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Sequencing Determine the amino acid sequence of protein or peptide.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
Quantitative MS Quantify small and large molecules in the pg/ml range
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

REACH Services

Hazard, Exposure and Risk Assessment Evaluate the known hazard of a test compound in conjunction with the expected quantity and frequency of exposure.

Real World Evidence & Data

Data Asset Validation Tools for validating that patient data and source has been accurately recorded.
Data Merging Tools for combining various data sets into a single data set. Includes data consolidation.
RWD - Genomics Genomic data collected from a patients with different diseases, can be derived from a range of sources.
RWD - Oncology Data from oncology patients, can include clinical treatment, diagnosis, among others.

Safety Pharmacology

Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Implanted Telemetry Study - Monkey / Non-human Primate Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in monkeys/non-human primates.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.

Scientific Data Services

Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
Cancer Systems Biology Convert complex molecular data obtained from high-throughput technologies to deducible information.
Data Curation Organize and integrate data collected from various sources to ease data discovery and retrieval.
Data Infrastructure Design and deploy an information management solution suited to users' specific needs.
Data Lineage & Quality Track the various processes through which data has been created, edited or exchanged.
Data Quality Framework Manage data quality issues to maintain good quality data outputs.

Show all 18 in Scientific Data Services 12 more

Discovery Computational Systems Biology Model the interaction of biological system with drug candidates.
In Silico Genomics/Transcriptomics Data Analysis Interpret DNA sequencing and microarray data.
In Silico Metagenomics/Metatranscriptomics Data Analysis Use software to analyze genomic information from multiple environmental sources.
Marker Analyses Identify associations between genetic markers and traits of interest to determine markers responsible for human diseases.
Metabolomics Data Analysis Use metabolites to identify any potential biomarkers or novel therapeutic targets that may play a role in the mechanisms responsible for the progression of a disease.
Metagenomics Data Analysis Deconvolute the genetic content of genomes contained in environmental samples by utilizing whole genome sequencing techniques to provide insight into microbial communities and host phenotypes.
Microbiome Data Analysis Determine the population composition of a microbial community and analyze its contribution to human or animal health.
Molecular Phylogenetics Analyze hereditary molecular differences in genomic sequences to compare genomes.
Mutation Data Profiling Guide treatment decisions in cancer based on the identification of genomic mutations .
Pharmaco-genomics Genetic polymorphism contribution to inter-individual variability in drugs' responses and/or adverse events.
Scientific Data Visualization Exploration and reporting of data by means of graphs and plots.
Small RNA Gene Expression Quantify and analyze miRNA, piRNA, siRNA as well as other small nuclear RNAs from small-RNA-seq raw input data sets.

Specialty Dosing Routes

Ophthalmologic Toxicology Measure toxicity by microscopy, vitrectomy, tonometry, electroretionography and corneal colorimetry.
Repeat Dose Intravenous Infusion Study - Monkey / Non-human Primate Conduct a repeat dose intravenous infusion study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Monkey / Non-human Primate Conduct a single dose intravenous infusion study in monkeys/non-human primates to determine the toxicokinetic behavior of your compound.

Target Animal and Human Food Safety

Tolerance Studies Conduct tolerance studies on target animals of veterinary products.
Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.

Other services

BD FACSCanto II Use 3 laser bench-top digital flow cytometers to analyze forward and side scatter and 8 flourochromes.
New Request  
Pfizer Sourcing Request Initiate a new request supported by a Pfizer Sourcing Group
Transcriptome In Vivo Analysis (TIVA) Use TIVA for photo-activated capture of mRNA from a single cell or sub-cellular region.

Service areas:

Biology DMPK Pharmacology Toxicology

China Changping District, Shanghai, Suzhou City, Taicang City 4 sites
United States San Diego, Frederick, Kannapolis 4 sites
Germany Hamburg 1 site
Japan Tokyo 1 site
Netherlands Leiden 1 site

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Crown Bioscience Inc. leads the field in providing unique translational platforms and cost effective drug discovery solutions for its biotech and pharmaceutical partners in dedicated two therapeutic areas: Oncology and Metabolic Disease. Crown Bioscience provides oncology PDX translational biology services as well as cancer cell profiling, antibody development, molecular and structural biology services, DMPK analysis, 128 cell-line derived in vivo oncology models and biomarker ID services. We aspire to become the innovative engine for the global biotech and pharmaceutical industry. Rather...

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We aspire to become the innovative engine for the global biotech and pharmaceutical industry. Rather than building a fully integrated pharmaceutical company, we focus on working with partners to deliver innovative solutions and molecules for clinical development. Leveraging our unique drug discovery and translational research platforms, we help partners develop the best drug candidates with high confidence for clinical development, thus reducing drug attrition and development cost.

Website: www.crownbio.com

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