Supplier site
Group of sites (click to zoom)

Scientist.com supplier network (site locations)

Research supplier

Axcelead Drug Discovery Partners, Inc.

Axcelead Drug Discovery Partners, Inc. is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 1 country.

View Axcelead Drug Discovery Partners, Inc. on Scientist.com

Email me this page as a PDF

Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 2

Countries 1

Type of company: Mid sized business

Bioimaging

Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.
Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
In Vivo Imaging In-vivo imaging using PET, MRI, CT etc.
In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.
Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.
Medical Imaging Visualize and analyze internal structures in animal models or patients.

Show all 8 in Bioimaging 2 more

Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
Ultrasonography diagnostic imaging technique, or therapeutic application of ultrasound.

Biomarkers

Antioxidant Assays Use biochemical, cell-based or in vivo assays to measure total antioxidant capacity.
Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.

Show all 38 in Biomarkers 32 more

Chemotaxis Assays Investigate the in vivo or in vitro movement of cells towards or away from a chemotactic agent.
Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Fluorescent In Situ Hybridization Use FISH to identify abnormal chromosome structures and to quantify specific DNA sequences.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Histamine Release Assay Use in vivo or in vitro assays to measure the release of histamine in response to an allergen stimulation.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
Lipid Profiling Use quantitative analysis of blood lipid components to assess cardiac risk.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Peptide Bioanalysis Analyze the structure of Peptides.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Propidium Iodide FACS Analysis Use DNA staining and flow cytometry to analyze the cell cycle and detect apoptosis or cell proliferation.
Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
Single Cell Isolation Isolate single cells for subsequent single-cell analysis.
Single Cell quantitative Real Time-PCR Assess gene expression levels and patterns in a single cell.
Single Cell Transcriptome Sequencing Detect distinct, rare or abnomal cell types in a heterogenous population.
Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Special Stainings Use a variety of techniques for the selective visualization of specific tissue or cell types.
Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.
T Cell Epitope Characterization Evaluate the potency and immunodominance of T-cell epitopes within a molecule.
TUNEL Assay Detect in situ DNA fragmentation.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

Show all 338 services 326 more

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.

Show all 14 in Cell Culture and Characterization 8 more

Gene-Edited iPSCs Disease Models Use gene-edited iPSCs to model human diseases.
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Induced Pluripotent Stem (iPS) Cell Reprogramming Generate induced pluripotent stem cells from adult somatic cells.
Isogenic Knockout iPSC Lines Mimic loss of function of genes associated with various diseases and disorders.
Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.
Single Cell DNA Sequencing Examine genetic variations in a single cell.
Trichrome Staining Use a variety of techniques for the selective visualization of muscle, collagen fibers, fibrin and erythrocytes.
Viral Mediated Gene Delivery Use viral carriers to introduce new genetic material into a cell.

Chemical and Compound Analysis

Computed Tomography Visualize the internal features of solid objects.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
Isothermal Titration Calorimetry An ITC assay will be established and optimised for the affinity measurement of test substance to target molecule.
Ultrasound Tomography Use the transmission and acquisition of ultrasound waves to create a non-invasive technique for imaging.

Chemical and Compound Testing

Clinical Pathology Diagnose disease based on the laboratory analysis of bodily fluids, such as blood, urine and tissues.

Discovery Chemistry

Activity Prediction Identify possible chemical hits based on the known three-dimensional structure of a protein.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
In Silico Lead Optimization Use in silico design to enhance the ADME-PK properties of candidate drugs to maximize efficacy and safety.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.

Show all 10 in Discovery Chemistry 4 more

Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
Blood Models Test for therapeutic efficacy of drug candidates in blood disorder models.
Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.

Show all 32 in Disease Models 26 more

Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
Cognition Models Measure therapeutic endpoints in animal models of cognition.
Demyelination Models Measure therapeutic endpoints in animal models with demyelination pathology.
Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
Electroencephalogram EEG Models Record electrical activity along the scalp of animal models or human patients.
Hematopoiesis Models Measure therapeutic endpoints in animal models of hematopoiesis.
In Vivo Physiologic Monitoring Monitor and collect data from conscious, freely moving laboratory animals.
In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Ischemia Models Measure therapeutic endpoints in animal models of ischemia.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Microdialysis Models Measure the effect of drug candidates on neurotransmission in rat or mouse models.
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Ob/ob Mouse Use a single animal species to create one or more disease models obesity and angiogenesis.
Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Object Recognition Measure spatial navigation, working memory and cognitive function in animal models.
Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
Schizophrenia Models Measure therapeutic endpoints in animal models of schizophrenia.
SHR/NCrl Rat Use a single animal species to create one or more disease models fior hematopoesis.
Stroke Models Measure therapeutic endpoints in animal models of stroke.
Systemic Lupus Erythematosus Models Measure therapeutic endpoints in animal models of immune disorders such as SLE and lupus.
Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

Capillary Electrophoresis Separate ng quantities of DNA to single base resolution.
cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
Cell Free DNA Assay Detect known mutations and discover new ones in cell-free plasma DNA.
CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
Digital Polymerase Chain Reaction Obtain improved absolute target quantification and rare allele detection compared to conventional qPCR.
DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.

Show all 24 in DNA & RNA 18 more

DNA Products Find DNA products including gDNA, cDNA clones, vectors and constructs from mice, insects, yeast, bacteria and viruses.
DNA/RNA Extraction & Purification DNA/RNA Extraction & Purification.
Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
Genotyping Examine a DNA sequence to identify specific genetic varients .
Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
Poly (A) tail Length Profiling (PAL-Seq) Conduct high-throughput sequencing of individual mRNA poly (A) tails.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
Recombinant Nucleosomes Use as substrates in histone methyltransferase or acetyltransferase assays.
RNA Amplification Produce RNA from pre-clinical and clinical samples for use in gene expression studies.
RNA Extraction Isolate total RNA or mRNA from cells or tissues
RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Cellular Immunology Consulting Immunological activities of cells in experimental or clinical situations
Consulting Services Work with consultants who provide expert advice in various areas of research and technology.
Pathophysiology Consulting Request services related to Pathophysiology Consulting
Pharmacogenetics Consulting Access genomic services required for clinical trials, such as genotyping, genetic variation testing and DNA isolation.
Pharmacology Consulting Request consulting services related to pharmacology and the chemical properties, biological effects, and therapeutic uses of drugs.

Show all 9 in Drug Development 3 more

Small Molecule Drug Development Consulting Request consulting services related to small molecule development.
Target Validation Consulting Help to demonstrate that modification of target activity has potential therapeutic benefits.
Toxicology Consulting Use models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

Human Biological Samples

Custom PDX models For requesting Custom PDX models
Existing PDX models For requesting Existing PDX models
Human Blood Acquire fresh/frozen human blood based on patient demographics, disease stage, history and treatment.
Human Bone Marrow Cells Acquire fresh, frozen, or fixed normal bone marrow based on patient demographics and history.
Human Cell Lysates For requesting human Cell lysates.
Human Cell Products For requesting human cell by products like proteins, lysates, lysosomes etc

Show all 21 in Human Biological Samples 15 more

Human Exosomes Request services related to the creation and development of human exosomes
Human Fixed Tissue Acquire Human fixed tissue based on patient demographics, disease stage, history and treatment.
Human Fresh Tissue For requesting fresh human tissue
Human Frozen Tissue For requesting frozen human tissue.
Human Immortalized Cell Culture For requesting human cells Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have been isolated from fresh tissue (or cultures) that...
Human iPSC's For requesting human sourced induced pluripotent stem cells.
Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
Human Plasma Acquire fresh/frozen human plasma
Human Primary Cells Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely”...
Human Red Blood Cells Acquire fresh/frozen normal red blood cells based on patient demographics and history.
Human Serum Acquire fresh/frozen normal serum based on patient demographics and history.
Human Urine Acquire fresh/frozen normal urine based on patient demographics and history.
Human Whole Blood Acquire fresh/frozen normal whole blood based on patient demographics and history.
Human Whole Blood For requesting Human Whole Blood
Human Whole Organs Procure non-transplantable whole human organs or tissues, healthy or diseased, for medical research and development.

In Vitro ADME

Cell Fractionation Isolate organelles and subcellular components.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.

In Vitro Assays

3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.

Show all 24 in In Vitro Assays 18 more

Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Cycle Assays Measure cell cycle markers and the molecular events that control cell cycle progression.
Cell Proliferation Measure cell number, cell viability and cell division.
Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
Fully Automated Assays Develop and perform assays that require no manual steps
Glucose Release Assay Determine free glucose levels in biological samples.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
HTS Assay Development Develop assays to use in high throughput screening.
Hydroxyproline Assays Use biochemical, cell based or in vivo assays to quantify hydroxyproline or collagen in a sample.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
Tube Formation Assay Monitor the in vitro formation of three dimensional 3D tube structures.

In Vitro Pharmacology

Anaplastic lymphoma kinase (ALK) Assays Use biochemical, cell based or in vivo assays to measure ALK enzyme activity.
ATP Competitive Study Determine whether or not a compound is competitive with ATP.
B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
Chloride Channel Assays Use biochemical, cell-based or in vivo assays to measure chloride channel activity.
Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Assays Use biochemical, cell based or in vivo assays to measure CTLA-4 receptor activity.

Show all 65 in In Vitro Pharmacology 59 more

Dehydrogenase Assays Measure dehydrogenase activity in biochemical and cell-based assays.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
Extracellular signal Regulated Kinase Assays Use biochemical, cell based or in vivo assays to measure ERK enzyme activity.
Fibroblast Growth Factor Receptor (FGFR) Assays Use biochemical, cell based or in vivo assays to measure FGF receptor activity.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
Histone Acetyltransferase (HAT) Assays Use biochemical, cell-based or in vivo assays to measure histone acetyltransferase activity.
Histone Deacetylase (HDAC) Assays Use biochemical, cell-based or in vivo assays to measure histone deacetylase activity.
Human BCL Assays Use biochemical, cell-based or in vivo assays to measure BCL activity.
Human Epidermal growth factor Receptor (HER) Assays Use biochemical, cell based or in vivo assays to measure HER receptor activity.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
In Vitro Bone Models Measure osteoclast activity and bone formation in human or rat osteoclasts.
In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
In Vitro Hemolysis Assay Evaluate the toxicity of a drug, metabolite or excipient by hemolytic release of hemoglobin in the plasma.
In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Mammalian Target of Rapamycin Complex Assays Use biochemical, cell based or in vivo assays to measure mTORC enzyme activity.
Methyltransferase Assays Use biochemical, cell-based or in vitro assays to measure methyltransferase activity.
Mitogen/Extracellular signal-regulated Kinase (MEK) Assays Use biochemical, cell based or in vivo assays to measure MEK enzyme activity.
Mutant B-Raf Assays Use biochemical, cell based or in vivo assays to measure mutant B-Raf enzyme activity.
Nitric Oxide Synthase Assays Measure nitric oxide synthase activity by biochemical or cellular assays.
Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
Nucleoside Transporter Assays Use biochemical, cell-based or in vivo assays to measure nucleoside transporter activity.
Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
PARP Assays Use biochemical, cell-based or in vivo assays to measure PARP activity.
Peptide Transporter Assays Use biochemical, cell-based or in vivo assays to measure peptide transporter activity.
Peroxidase Assays Measure peroxidase activity in bacterial and mammalian cells.
Phosphatase Assays Use biochemical, cell-based or in vitro assays to measure phosphatase activity.
Phosphatidylinositol 3-Kinase (PI3K) Assays Use biochemical, cell based or in vivo assays to measure PI3K enzyme activity.
Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Programmed Death-Ligand 2 (PD-L2) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of PD-L2 ligand.
Protease Assay Measure protease activity in biochemical and cell-based assays.
Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Protein/Enzyme Targets For requesting Protein/Enzyme Targets
Raf Assays Use biochemical, cell based or in vivo assays to measure Raf enzyme activity.
RAS Assays Use biochemical, cell based or in vivo assays to measure RAS enzyme activity.
Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
Solute-Linked Carrier (SLC) Transporter Inhibition Assays Use biochemical, cell-based or in vivo assays to measure solute-linked carrier transporter activity.
Solute-Linked Carrier (SLC) Transporter Substrate Identification Use biochemical, cell-based or in vivo assays to identify solute-linked carrier transporter substrates.
Target Characterization Characterize potential drug targets during the drug discovery process.
Target Identification Identify the target(s) of a biologically active substance.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
Time Dependent Study Determine whether or not a compound binds to an enzyme in a time-dependent manner.
Transporter Assays Use biochemical, cell-based or in vitro assays to measure transporter target activity.
Ubiquitin Ligase Assays Measure ligase enzyme activity in the presence of cofactors or chemical modifiers.
UDP-glucuronosyltransferases (UGT) Inhibition Assays Use biochemical, cell-based or in vivo assays to measure UDP-glucuronosyltransferase activity.
Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.
Vascular Endothelial Growth Factor Receptor (VEGFR) Assays Use biochemical, cell based or in vivo assays to measure VEGF receptor activity.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cytotoxicity Test for effects on cell viability and proliferation
Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.

Show all 8 in In Vivo Pharmacokinetics 2 more

Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.

Medical Communications

Target Product Profile (TPP) A sponsor prepared document which summarizes the drug development program that is described in terms of the labelling concepts. This profile is a communication method used between the FDA and sponsor which can be used...

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Custom Model Development Develop a custom disease model.
Fresh Functional Human Tissue Vasoconstriction Assays Use fresh functional human tissue to assess vasoconstriction with various compounds.
Fresh Functional Human Tissue Vasodilation Assays Use fresh functional human tissue to assess vasodilation with various compounds.
Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.

Show all 14 in Model Development 8 more

Lewis Rat Use a single animal species to create one or more disease models for metastatic cancer, hematopoiesis and anemia.
Pulmonary Hypertension Animal Model Study the pathology of pulmonary arterial hypertension (PAH) and investigate potential therapies.
SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.
Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.
Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.
Zucker Rat Use a single animal species to create one or more disease models for cachexia.

Nanotechnology

Drug Delivery Technology Create microstructures that enhance drug metabolism properties.
Liposomes Create artificial spherical vesicles that can be used as a vehicle for administration of drugs.
Nanofabrication Enable the construction of functional structures with nanoscale dimensions.
Nanoparticle Conjugation and Functionalization Modify biomolecules to enhance structure and function.
Nanoparticle Synthesis Create nano-level structures with unique features.

Non-Human Biospecimen

Dog / Canine Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Dog / Canine Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Monkey / Non-Human Primate / NHP Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Mouse Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Pig / Minipig / Porcine Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Pig / Minipig / Porcine Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.

Show all 8 in Non-Human Biospecimen 2 more

Rat Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Rat Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.

Oncology Models

Cachexia Models Measure therapeutic endpoints in animal models of cachexia.
Endocrine System Xenograft Xenografts derived from organs and glands of the Endocrine system. This include samples from the Pituitary Gland, Thyroid, and Adrenals.
Nervous System Xenografts Xenografts relating to the Nervous system. This includes samples from the Head, Neck, Brain, and Nerves.
Oncology Derived PDX Patient derived xenografts derived from various oncological samples. This includes, but is not limited to, samples from Lymphoma, Melanoma, and Leukemia.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Oncology Xenografts Xenografts derived from oncological samples.

Show all 11 in Oncology Models 5 more

Oral Xenograft Measure therapeutic endpoints in oral cancer models as well as cancer models related to the Pharynx.
Renal Xenograft Measure therapeutic endpoints in renal models of cancer.
Reproductive System Xenografts Xenografts relating and derived from the reproductive systems. This includes samples from the ovaries, cervix, vulva, uterus, testes, scrotum, and prostate.
Urinary System Xenografts Xenografts derived from organs of the Urinary system. This includes, but is not limited to, xenografts from the Bladder, Kidney, and Urethra.
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Protein Sciences

Adeno Associated Virus (AAV) Production Clone into AAV expression vectors and produce high titer viruses.
Affinity Tag Purification Purify proteins under physiological conditions at their native cellular levels.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.
Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.

Show all 15 in Protein Sciences 9 more

Lentivirus Production Develop lentiviruses and production protocols.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Purification Isolate native or recombinant proteins from a sample.
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.

Safety Pharmacology

Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Implanted Telemetry Study - Dog / Canine Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in dogs/canines.
Implanted Telemetry Study - Monkey / Non-human Primate Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in monkeys/non-human primates.
Implanted Telemetry Study - Rat Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in rats.
Jacketed External Telemetry (JET) Study - Dog / Canine Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in dogs/canines.
Jacketed External Telemetry (JET) Study - Monkey / Non-human Primate Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in monkeys/non-human primates.

Show all 8 in Safety Pharmacology 2 more

Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Telemetry Use implantable or external devices to study physiological parameters in model organisms

Specialty Dosing Routes

Repeat Dose Intranasal Study - Mouse Conduct a repeat dose intranasal study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Mouse Conduct a single dose intranasal study in mice to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Dog / Canine Conduct a single dose intravenous infusion study in dogs/canines to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Monkey / Non-human Primate Conduct a single dose intravenous infusion study in monkeys/non-human primates to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Other Species Conduct a single dose intravenous infusion study in other species to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Rats Conduct a single dose intravenous infusion study in rats to determine the toxicokinetic behavior of your compound.

Testing Services

OECD 439: Skin Irritation Test (SIT) Reconstructed Human Epidermis Test (RhE) Method - An in vitro testing method designed to identify chemicals and/or mixtures capable of inducing moderate skin irritation.
Phototoxicology Phototoxicity testing identifies and evaluates the potential of chemical agents to induce toxicity upon subsequent exposure to light.

Other services

New Request

Website: axcelead-us.com

Japan Fujisawa 2 sites

Work with Axcelead Drug Discovery Partners, Inc. on Scientist.com

For prices, more details, or to contact Axcelead Drug Discovery Partners, Inc., visit Scientist.com.

View on Scientist.com