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Cyprotex plc
Cyprotex plc is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 2 countries and 2 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Biomarkers
- Antioxidant Assays Use biochemical, cell-based or in vivo assays to measure total antioxidant capacity.
- Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
- Complete Metabolic Panel Testing Detect electrolyte or glucose imbalance to identify or monitor related disorders.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Show all 16 in Biomarkers
- Endocrine Assays Use biochemical, cell based or in vivo assays to measure the concentration of hormones.
- Focus Forming Assay Use colorimetric or immunofluorescence-based readouts to quantify virions prior to any plaque formation.
- Human Primary Cell Isolation Isolate primary cells from various human tissues.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
- Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
- Peptide Bioanalysis Analyze the structure of Peptides.
- Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
- Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Special Stainings Use a variety of techniques for the selective visualization of specific tissue or cell types.
Cell Culture and Characterization
- 2D Cell Culture Grow conventional cell cultures in monolayers.
- Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Chemical and Compound Analysis
- Bioanalysis Bioanalysis involves the determination of the concentration of test compounds in biological samples including plasma, urine, an...
- GC MS Analysis Use gas chromatography coupled to mass spectrometry to analyze compound integrity.
- MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
- NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
- Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Show all 13 in Chemical and Compound Analysis
- Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
- Photostability Measure drug degradation rates after exposure to various light sources.
- Phototoxicity & Photosensitization Test Test the potential for a product to elicit a reaction under UV exposure.
- Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
- Viscosity Testing Evaluate the fluid flow properties of liquids for product evaluation and quality control.
Show all 211 services
Chemistry, Manufacturing and Controls (CMC)
- Analytical Development and Validation Request services related to Analytical Development and Validation
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- IND Enabling Package Request a package of Investigational New Drug (IND) Enabling Studies from our group of trusted suppliers that have enrolled in our IND-Enabling Package Program.
- Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Clinical Consulting
- Bioanalysis Consulting Expert advice to properly and effectively discover, evaluate, and measure chemical or biological materials.
- Clinical Data Management Collect, analyze and interpret data on clinical data/specimens for review by regulatory agencies.
Clinical Trials
- Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.
Data Science/Bioinformatics
- Clinical Biomarker Analysis An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
- Clinical Data Management A process that includes acquiring, validating, storing, protecting, and processing required data to ensure the accessibility, reliability, and timeliness of the data.
- Discovery In Silico Drug Dynamics Develop In Silico model of a drug candidate with a biological system with applications such as Pro-drug Predictions, ADME-PK Due Diligence, Brain-Barrier Permeability Simulation, Drug Absorption Simulation, In Silico...
- Discovery In Silico Genomics/Transcriptomics Data Analysis A process that helps make sense of your Genomics/Transcriptomics data
- Discovery Machine Learning/AI Complex analytical approaches to find patterns and make predictions in drug discovery projects.
- In Silico ADME-PK Consultation Consult with experts for ADME-PK data analysis or predictive modelling design in different in vivo or in vitro states.
Show all 11 in Data Science/Bioinformatics
- In Silico ADME-PK Predictions Use computer software to simulate in vivo physiological conditions of animals or humans to predict ADME-PK properties.
- In Silico Drug-Drug Interactions Use computational tools to predict pharmaceutical, pharmacodynamic or pharmacokinetic drug-drug interactions to maximize drug regimen safety.
- In Silico Epigenetic Compound Library Screening Use computer-aided methods to discover new compounds against key regulators of epigenetic signaling.
- In Silico Pro-drug Predictions Use computer simulation to assess pro-drug absorption and conversion to predict pharmacokinetic properties.
- Translational In Silico Genomics/Transcriptomics Data Analysis A process that helps make sense of your omics data
Developmental and Reproductive Toxicology (DART)
- Bioelectronics Evaluate an application (e.g. device) that integrates biological materials and micro and nano-electronics.
Discovery Chemistry
- In Silico Metabolite Predictions Conduct in silico assessment of metabolite pharmacokinetic properties and potential exposure effects.
- Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
- Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.
Disease Models
- Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
DNA & RNA
- In Situ Hybridization Localize specific nucleic acid targets using labeled complementary probes.
Drug Development
- Toxicology Consulting Use models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
Drug Metabolism and Pharmacokinetics (DMPK)
- Biomarkers DMPK Biomarker DMPK and gene analysis services are critical tools in evaluating patients and discovery of new therapeutics.
General in vivo Toxicology
- Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
- Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
- Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
- Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
- Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
Show all 45 in In Vitro ADME
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
- GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
- HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
- Human Blood Brain Barrier on a Chip (BBBoC) Create a blood–brain barrier multicellular model to test drug delivery to the brain.
- In Vitro ADME in Vitro ADME services
- In Vitro Biologic-Small Molecule Drug-Drug Interaction Studies Patented approach to evaluate the potential of large &/or small molecule drugs to cause DDI directly or through cytokine effect.
- Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
- Isotopic Labeling Track labeled isotopes through a metabolic pathway or cell by measuring mass, vibrational mode or radioactive decay.
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
- Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
- Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
- Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
- Multidrug Resistance Identify potential causes of drug-drug interactions.
- N Acetyl Transferase Detect NAT induction and identify any acetylated-drug conjugates that are formed.
- Nasal Permeability Test for passive diffusion and active transport in nasal permeability models.
- No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
- Non Isotopic Labeling Track unlabeled macromolecules through a metabolic pathway or cell.
- Ocular Permeability Measure passive diffusion and active transport of drugs across confluent ocular epithelial cells.
- PharmacoScan - A Pharmacogenomics Tool Understand how genetic variation affects drug absorption, distribution, metabolism, and excretion (ADME) in a microarray plate.
- Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
- Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
- Radiolabeled Tracers Use radiolabeled drug metabolites as radiotracers for measuring desired physiological processes.
- Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
- Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
- Reference Standards Find reference standards for assays, tests and services.
- Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.
- Sulfotransferase Detect sulfotransferase (SULT) induction and the formation of sulfonated-drug conjugates.
In Vitro Assays
- 3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
- Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Assay Development Construct or create new assays or modify existing ones.
- Biosensor Assays Evaluate biological activity of new compounds, detect toxic metabolites or monitor biomarkers.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Show all 27 in In Vitro Assays
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell Painting Cell painting is multiplexed image-based assay used to investigate subtle changes in cellular homeostasis
- Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Endpoint Dilution Assay (TCID50) Assay Determine the viral titer to induce cell death in half the cell population of an inoculated tissue culture.
- Epidermal Sensitization Assay (EpiSensA): OECD 442D Validated in vitro skin sensitization
- Fully Automated Assays Develop and perform assays that require no manual steps
- Glucose Release Assay Determine free glucose levels in biological samples.
- Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
- High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
- HTS Assay Development Develop assays to use in high throughput screening.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
- Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
- Monoamine Transporter Assays Measure monoamine neurotransmitter uptake in cultured cells.
- MTT Test Measure the viability of living cells via mitochondrial dehydrogenase activity.
- Organoid Screening Assay Evaluate the effects of various substances, such as drugs or genetic modifications, on organoids.
- Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
- Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
- Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
- Reactive Species Assays Use biochemical, cell-based or in vivo assays to detect and evaluate the effects of reactive species.
In Vitro Pharmacology
- ATP Competitive Study Determine whether or not a compound is competitive with ATP.
- Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- Human BCL Assays Use biochemical, cell-based or in vivo assays to measure BCL activity.
- In Vitro Eye Models Measure cytokine production, cell viability, apoptosis and wound healing.
- In Vitro Hemolysis Assay Evaluate the toxicity of a drug, metabolite or excipient by hemolytic release of hemoglobin in the plasma.
Show all 22 in In Vitro Pharmacology
- In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
- In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
- Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
- Nitric Oxide Synthase Assays Measure nitric oxide synthase activity by biochemical or cellular assays.
- Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
- Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
- Peptide Transporter Assays Use biochemical, cell-based or in vivo assays to measure peptide transporter activity.
- Peroxidase Assays Measure peroxidase activity in bacterial and mammalian cells.
- Reversibility Study Determine whether or not a compound inhibits an enzyme reversibly.
- Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
- Solute-Linked Carrier (SLC) Transporter Inhibition Assays Use biochemical, cell-based or in vivo assays to measure solute-linked carrier transporter activity.
- Solute-Linked Carrier (SLC) Transporter Substrate Identification Use biochemical, cell-based or in vivo assays to identify solute-linked carrier transporter substrates.
- Substrate Competitive Study Determine whether or not a compound is competitive with a substrate.
- Time Dependent Study Determine whether or not a compound binds to an enzyme in a time-dependent manner.
- Transporter Assays Use biochemical, cell-based or in vitro assays to measure transporter target activity.
- UDP-glucuronosyltransferases (UGT) Inhibition Assays Use biochemical, cell-based or in vivo assays to measure UDP-glucuronosyltransferase activity.
In Vitro Toxicology
- Cardiac Channels Measure the arrhythmia producing potential of test compounds.
- Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
- Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
- Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
- CH50 Assays Measure the functional activity of the classical complement activation pathway in serum or other fluid samples.
- Cytotoxicity Test for effects on cell viability and proliferation
Show all 17 in In Vitro Toxicology
- Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
- Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
- Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
- Genotoxicity Evaluate potential of a compound to cause mutations and chromosomal aberations
- Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
- HepaRG Cells Obtain terminally differentiated and cryopreserved hepatic cells that retain many characteristics of primary human hepatocytes.
- Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
- hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
- Microelectrode Array Cardiotoxicity Assays Use microelectrode array to measure cardiotoxicity-related activities.
- Short Time Exposure (STE) Test Use in vitro eye irritation tests to assess cytotoxicity in SIRC cells (rabbit corneal cell line).
- Toxicology- in vitro Toxicity testing and model development in vitro on developmental and adult neurotoxicity
In Vivo ADME
- Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
In Vivo Pharmacokinetics
- Cardiac Safety Assessment Assess cardiotoxicity using microelectrode assay technology.
- Integrated In Vivo Services Package Process an entire In Vivo Project including: Dose Formulation, PK Screening, ADME-Profiling, Toxicology, Safety Pharmacology, DART, IND Filing from our bundle of suppliers.
- Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
- Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Model Development
- Fresh Functional Human Tissue Permeability Assays Use fresh functional human tissue to assess tissue permeability with various compounds.
- Fresh Functional Human Tissue Vascular Permeability Assays Use fresh functional human tissue to assess vascular permeability with various compounds.
- In Silico PK-PD Modeling Quantitative modeling and simulations correlation of pharmacokinetic and pharmacodynamic endpoints in support of preclinical and clinical development.
Other Specialty Toxicology
- Phototoxicity Determine whether drug treatment causes light-activated toxic effects.
- Residual DNA Analysis Measure contaminants found in therapeutics like biologicals and biosimilars that are produced in cells.
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
- Protein Binding Determine drug-protein binding interactions
Radioanalysis
- Stand-alone Radioanalysis of Animal Pre-clinical Samples Conduct analysis of radioactive samples from preclinical radiolabeled studies.
- Stand-alone Radioanalysis of Human Clinical Samples Conduct analysis of radioactive samples from clinical metabolism radiolabeled studies.
REACH Services
- In Vitro Skin Sensitization Determine whether a drug or cosmetic product may cause dermal sensitization.
- OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
Regulatory Consulting
- Toxicology Data Review Identify relevant toxicological endpoints for “No Observed (Adverse) Effect Level” (NO(A)EL) or “Lowest Observed (Adverse) Effect Level” (LO(A)EL).
Safety Pharmacology
- Cytokine Release Syndrome In Vivo assessment of cytokine release syndrome liability in a humanized mouse
- Endocrine Disruptor Screening Use biochemical, cell based or in vivo assays to identify and quantify endocrine-modulating agents.
- Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
- Microelectrode Array Neurotoxicity Assays Use microelectrode array to measure neurotoxicity-related activities.
- Neurotoxicity Study Study of the adverse effects of a substance on the brain or peripheral nervous system.
- Safety Screen Panel Assays Safety Pharmacology safety screen panel assays enable early identification of significant off-target interactions with your compound(s)
Show all 8 in Safety Pharmacology
- Seizure Liability Study - Other Species Conduct a study to determine the seizure risk of your compound in other species.
- Target Safety Assessment Understand the role of your drug target and assess risks in normal physiology.
Scientific Data Services
- Machine Learning/ AI Predict and model an outcome (e.g. disease progression) based on input variables (i.e. features.)
Testing Services
- Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
- Cosmetics safety assessments Conduct safety assessments such as Microbiological quality, Margin of Safety, and information about the packaging material of cosmetic products.
- Ex Vivo Eye Irritation Test (EVEIT) Use optical coherence tomography (OCT) to monitor full-thickness recovery of corneal tissue.
- In Vitro Oral Care Product Testing Perform in vitro oral care product testing of dental products to evaluate safety and performance, including assessment for cleaning, brushing, whitening, stain removal, erosion, abrasivity and sensitivity.
- In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
- In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Show all 14 in Testing Services
- Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
- Ocular Irritation Test Use human subjects to determine whether a cosmetic product or ingredient can cause ocular irritation.
- OECD 435: Skin Corrosion Test - Membrane Barrier Method Use in vitro models to determine whether a cosmetic product or ingredient can cause skin corrosion.
- OECD 442C: Direct Peptide Reactivity Assay (DPRA) Determine whether a test article satisfies the protein-binding criterion for skin sensitizers.
- OECD 442D: ARE-Nrf2 Luciferase Test An in vitro test method (KeratinoSensTM and/or LuSens) that models the second key event in the Adverse Outcome Pathway for Dermal Sensitization.
- OECD TG 492: Ocular Irritation Testing Use in vitro skin models to determine whether a product can cause dermal sensitization (e.g. EpiOcular Eye Irritation Test - EIT)
- Phototoxicity and Photosensitization Screening Screen a consumer healthcare product for irritancy and/or allergy potential following exposure to UV light.
- Phototoxicology Phototoxicity testing identifies and evaluates the potential of chemical agents to induce toxicity upon subsequent exposure to light.
Other services
- eCiphr®Neuro - In Vitro Neurotoxicity Assays Assess neurotoxicity using microelectrode assay technology.
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
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United Kingdom 1 site
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Cyprotex (www.cyprotex.com) is listed on the AIM market of the London Stock Exchange (CRX). We have sites in Macclesfield and Alderley Park, near Manchester in the UK, Watertown, MA and Kalamazoo in MI in the US. The company was established in 1999 and works with more than 1000 clients. Our core capabilities include in vitro ADME-Tox (both discovery and IND-enabling regulatory studies), PBPK and QSAR predictive modelling, and a range of GLP and non-GLP skin, ocular and endocrine disruption services. The company serves the Pharmaceutical and Biotech, Cosmetics/Personal Care and Chemicals...
Show the full description
Cyprotex (www.cyprotex.com) is listed on the AIM market of the London Stock Exchange (CRX). We have sites in Macclesfield and Alderley Park, near Manchester in the UK, Watertown, MA and Kalamazoo in MI in the US. The company was established in 1999 and works with more than 1000 clients. Our core capabilities include in vitro ADME-Tox (both discovery and IND-enabling regulatory studies), PBPK and QSAR predictive modelling, and a range of GLP and non-GLP skin, ocular and endocrine disruption services. The company serves the Pharmaceutical and Biotech, Cosmetics/Personal Care and Chemicals Industries. The acquisition of Apredica and the assets of Cellumen in 2010 and the assets and business of CeeTox in 2014 has enabled Cyprotex to increase its range of services, address new markets and expand geographically. We have developed a number of unique technologies in the field of ADME-Tox including Cloe® PK and Cloe® HIA which use PBPK modelling in conjunction with in vitro ADME and physicochemical data to predict pharmacokinetics, CellCiphr® Premier which combines high content screening data with in silico approaches to predict hepatotoxicity, eCiphrCardio and eCiphrNeuro which utilise high throughput microelectrode array to predict cardiac and neuronal function and SenCeeTox® to predict skin sensitization potential. We focus heavily on R&D and our goal is to continually develop and improve approaches to more accurately predict human clinical outcome following exposure to a drug or chemical using robust in vitro methods combined with in silico technology.
- Professional associations
- MassBio, SOT
- Website
- www.cyprotex.com
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