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Syngene International

Syngene International is listed as a large business research supplier in the Scientist.com network, with 2 sites in 1 country and 5 service areas.

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Sites 2

Countries 1

Type of company: Large business

Agricultural Sciences Research & Development

General Agrochemical Compound Library Find potential compound candidates for agrochemical or agro-product research and development.

Antibodies

Antibody Amplification Produce large amounts of antibody-based therapeutics.
Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody Detection Quantitate, localize and visualize proteins and other antigens.
Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.

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Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
Antibody Services Antibodies have become an essential tool in most life science and drug discovery research projects. Both monoclonal and polyclo...
Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
In Silico Humanization Predict epitope binding specificity, increase in vivo half-life and allow rapid modeling and humanization of antibodies.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.
SARS-CoV-2 (COVID-19) Antibodies Search for available SARS-COV-2 antibodies
SARS-CoV-2 (COVID-19) Protein and Antigen Search for available SARS-CoV-2 proteins and antigens
SARS-CoV-2 (COVID-19) Testing Search for available SARs-CoV-2 tests and testing services.

Bioimaging

Bioimaging Visualize biological process non-invasively in real time.
Medical Imaging Visualize and analyze internal structures in animal models or patients.

Biomarkers

Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Whole Transcriptome Amplification Amplify total RNA from a single cell.

Show all 279 services 266 more

Cell Culture and Characterization

Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Bacterial Cell Culture Culture and Grow bacterial cells.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Cell Services Most drug research projects routinely use a variety of cell research services including cell line construction, analysis of cells.

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cGMP Cell Banking Request information or a price quote for cGMP Cell Banking services
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Insect Tissue Culture Grow insect cells.
Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
Single Cell DNA Sequencing Examine genetic variations in a single cell.
Yeast Cell Culture Grow yeast strains or species.

Chemical and Compound Analysis

Chemical Stability Measure the stability of small molecules in solution.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.
Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.

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GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Natural Product Libraries Find microbial, botanical and marine sources of natural products.
NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.

Chemical and Compound Testing

Clinical Pathology Diagnose disease based on the laboratory analysis of bodily fluids, such as blood, urine and tissues.

Chemistry, Manufacturing and Controls (CMC)

Bulk Manufacturing Find facilities for large-scale mass production.
Chemistry Manufacturing Controls Access contract manufacturing and regulatory guidance in setting specifications and drug dosage formulations.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
Excipients Acquire synthetic or natural inert components to formulate therapeutic agents.

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Fill and Finish Processing Confirm final product sterility, formulation and packaging in the biopharmaceutical process.
Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
Process Development Optimize existing synthesis methods or develop alternate synthesis strategies.
Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
Tablet Manufacturing Use automatic or semi-automatic machinery to create various standard and non-standard tablets.

Clinical Consulting

Regulatory Consulting Ensure that each product or device complies with all FDA rules and regulations.

Clinical Trials

Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Clinical Research Services Determine the safety and effectiveness of medications and medical devices.

Data Science/Bioinformatics

Discovery Statistical and Mathematical Modeling Use mathematical variables and equations to establish relationships between data.
In Silico ADME-PK Consultation Consult with experts for ADME-PK data analysis or predictive modelling design in different in vivo or in vitro states.
In Silico ADME-PK Predictions Use computer software to simulate in vivo physiological conditions of animals or humans to predict ADME-PK properties.
In Silico Cancer Genomics/Cancer Transcriptomics Analysis Interpret DNA sequencing and microarray data for cancer studies.
In Silico Drug-Drug Interactions Use computational tools to predict pharmaceutical, pharmacodynamic or pharmacokinetic drug-drug interactions to maximize drug regimen safety.
In Silico Epigenetic Compound Library Screening Use computer-aided methods to discover new compounds against key regulators of epigenetic signaling.

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In Silico Nucleic Acid Microarray Analysis Use software to visualize and evaluate gene activity in response to various stimuli.
In Silico Pro-drug Predictions Use computer simulation to assess pro-drug absorption and conversion to predict pharmacokinetic properties.
In Silico Protein Microarray Analysis Use software to visualize and evaluate protein function and expression on a large scale.
In Silico Protein Sequence Analysis Use software to predict protein structural and functional features and secondary structure components.

Developmental and Reproductive Toxicology (DART)

Reproductive Toxicology Study adverse sexual function and fertility and examine teratogenicity of compounds.

Discovery Chemistry

Activity Prediction Identify possible chemical hits based on the known three-dimensional structure of a protein.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Finding Service Enter the compound name, CAS # or SMILES string in the box below or upload an Excel, Word or SD file with a list of compounds.
Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.

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Compound Synthesis Services (IP-sensitive) Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Custom Libraries Find or synthesize mg to kg amounts of target-specific and target-agnostic compounds for HTS and biological profiling.
Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
In Silico Lead Optimization Use in silico design to enhance the ADME-PK properties of candidate drugs to maximize efficacy and safety.
In Silico Metabolite Predictions Conduct in silico assessment of metabolite pharmacokinetic properties and potential exposure effects.
Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
Radiochemical Synthesis Radiolabel small molecules, peptides, cytotoxics or antibody drug conjugates for DMPK analysis.
Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Acute Kidney Failure Models Measure therapeutic endpoints in animal models of acute kidney failure.
Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
Alzheimer's Disease Models Measure therapeutic endpoints in animal models of Alzheimer's disease.
Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
Bone Models Measure therapeutic endpoints in animal models of bone disorders.

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Cartilage Repair Models Measure therapeutic endpoints in animal models of cartilage repair.
Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
General Pain Models Measure therapeutic endpoints in animal models of general pain.
In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
Irritant Models Measure therapeutic endpoints in animal models of skin irritation.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Osteoarthritic Pain Models Measure therapeutic endpoints in animal models of osteoarthritic pain.
Osteoarthritis Models Measure therapeutic endpoints in animal models of osteoarthritis.
OVA Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Pain Endpoints Models Measure therapeutic endpoints in animal models of pain.
Pain Models Test therapeutic efficacy of drug candidate in pain model.
Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
Skin Graft Models Measure therapeutic endpoints in animal models of skin grafts.
Streptozotocin Mice Use a single animal species to create one or more disease models for Type 1 diabetes.
Tissue Rejection Models Measure therapeutic endpoints in animal models of tissue rejection.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.

DNA & RNA

Amplicon 16s rRNA Sequencing Identify and compare bacteria present within a given sample.
cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
cDNA library construction Generate a library of recombinant cDNA clones.
CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
De Novo Genome Sequencing Determine the DNA sequence of uncharacterized genomes.
Degradome Sequencing Use parallel analysis of RNA ends (PARE) to detect miRNA targets and analyze patterns of RNA degradation.

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Digital Polymerase Chain Reaction Obtain improved absolute target quantification and rare allele detection compared to conventional qPCR.
DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
DNA Products Find DNA products including gDNA, cDNA clones, vectors and constructs from mice, insects, yeast, bacteria and viruses.
DNA Sequencing Determine the nucleotide sequence of DNA samples.
DNA Synthesis Produce DNA fragments for microarrays, PCR, cloning and expression studies.
Exome Sequencing Determine protein-coding nucleotide sequences in a DNA sample.
Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
Genotyping Examine a DNA sequence to identify specific genetic varients .
Metagenomic Sequencing Sequence genetic material recovered directly from environmental samples
NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
Restriction Fragment Length Polymorphism Identification Uses gel electrophoresis to identify differences in restriction fragment lengths produced by enzymatic digestion of DNA.
RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNAi Pathway Analysis Use high-throughput RNAi genetic screens to elucidate relevant signaling pathways.
Sanger Sequencing Sequence single strand DNA fragments using DNA Polymerase.
Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Targeted Sequencing/Resequencing Detect variations in a genome subset.
Whole Genome Amplification (WGA) Amplify an entire genome from a single cell.
Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.
Whole Genome Sequencing Determine the entire genetic make-up of an organism.

General in vivo Toxicology

Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.

Human Biological Samples

HBS Healthy/Controls For requesting HBS Healthy/Controls
HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
Human Blood Acquire fresh/frozen human blood based on patient demographics, disease stage, history and treatment.
Human DNA & RNA Acquire fresh/frozen Human DNA & RNA based on patient demographics, disease stage, treatment and history
Human iPSC's For requesting human sourced induced pluripotent stem cells.
SARS-CoV-2 (COVID-19) Human Biological Samples Search for available SARS-CoV-2 human biological samples

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Cell Fractionation Isolate organelles and subcellular components.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).

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CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
In Vitro ADME in Vitro ADME services
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Isotopic Labeling Track labeled isotopes through a metabolic pathway or cell by measuring mass, vibrational mode or radioactive decay.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Multidrug Resistance Identify potential causes of drug-drug interactions.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
Non Isotopic Labeling Track unlabeled macromolecules through a metabolic pathway or cell.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Reference Standards Find reference standards for assays, tests and services.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Proliferation Measure cell number, cell viability and cell division.
Coagulation Measure blood clotting, the aggregation of platelets or the maturation of fibrin.
HTS Assay Development Develop assays to use in high throughput screening.
In Vitro Human Cell Assays Request in vitro human cells for assays

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Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
SARS-CoV-2 (COVID-19) Assays Search for Available SARS-CoV-2 Assays

In Vitro Pharmacology

Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.

In Vitro Toxicology

Mouse Lymphoma Assay Assay for DNA damage in cells exposed to test substances.

In Vivo Pharmacokinetics

In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.

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Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Market Access

Marketing and Commercialization Identify, promote and prove the value of a particular drug to key stakeholders.

Model Development

Juvenile Toxicology Assess developmental and reproductive defects due to neurobehavioral, skeletal and muscle growth effects.
Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.
Zucker Rat Use a single animal species to create one or more disease models for cachexia.

Oncology Models

Cachexia Models Measure therapeutic endpoints in animal models of cachexia.
Muscle Wasting Models Measure therapeutic endpoints in animal models of muscle wasting.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.

Personal Care

Natural Products Find extracts from native living organisms with potential therapeutic effects.

Pharmacovigilance

GxP Compliance Monitoring Ensure products or services adhere to a set minimum standard.

Product Development

Aerosol Products - Manufacturing Manufacturing services for aerosol products (e.g. hairsprays and spray anti-perspirants)
Oral Care - Manufacturing Manufacturing services for oral care products
Oral Care Products - Formulation Formulation services for oral care products.
Over-The-Counter (Other) - Manufacturing Other manufacturing services for Over-The-Counter (OTC) products
Specialty (Other) - Manufacturing Other manufacturing services for specialty products in personal care

Protein Sciences

Adeno Associated Virus (AAV) Production Clone into AAV expression vectors and produce high titer viruses.
Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
Phage Display Use in vitro screening method to identify protein binding partners.
Protein Binding Determine drug-protein binding interactions

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Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Products Find native and recombinant proteins and peptides.
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.

Raw Materials

Film Formers Develop products that produce a continuous film on surfaces.

REACH Services

OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
OECD 474: Mammalian Erythrocyte Micronucleus Test The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone...
OECD 475: Mammalian Bone Marrow Chromosomal Aberration Test The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese...

Scientific Data Services

Cancer Systems Biology Convert complex molecular data obtained from high-throughput technologies to deducible information.
Data and Text Mining Derive structured data from free text in order to become accessible for data-mining algorithms.
Database Integration Convert bioinformatics results from multiple data sources (DSs) into a single operational format.
Discovery Computational Systems Biology Model the interaction of biological system with drug candidates.
Epigenomics Data Analysis Quantify and analyze DNA methylation and/or DNA binding protein data sets.
In Silico Genomics/Transcriptomics Data Analysis Interpret DNA sequencing and microarray data.

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In Silico Metagenomics/Metatranscriptomics Data Analysis Use software to analyze genomic information from multiple environmental sources.
Molecular Dynamics Software Run simulations that determine time-dependent behaviors of molecular systems.
Systems Network Analysis Analyze and visualize molecular pathways including gene regulatory, protein-protein and drug-target networks.
Systems Pharmacology Understand how drugs interact with different molecular and cellular systems within biological models.

Specialty Dosing Routes

Dermal Toxicology Assess toxicity in rodent dermal testing models.

Target Animal and Human Food Safety

Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.

Testing Services

ASTM E1207: Antiperspirant Clinical Testing Determine antiperspirant efficacy for products (e.g. deodorant) that are intended to be applied to the underarm.
Bacterial Reverse Mutation Assay Test whether a cosmetic product or ingredient causes DNA mutations in bacteria.
Characteristic Testing Characterization of physical and chemical properties of raw materials
Consumer Care Testing and Substantiation Test personal care products using analytical, in vitro, and microbial test services
Human Repeat Insult Patch Test (HRIPT) Examples of which include Topical Irritation, Allergenicity, Phototoxicity and Photoallergy testing.
In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.

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Ocular Corrosion Testing Use in vitro models to determine whether a product (or ingredient) can cause ocular corrosion.
Ocular Irritation Test Use human subjects to determine whether a cosmetic product or ingredient can cause ocular irritation.
OECD 435: Skin Corrosion Test - Membrane Barrier Method Use in vitro models to determine whether a cosmetic product or ingredient can cause skin corrosion.
OECD 442D: ARE-Nrf2 Luciferase Test An in vitro test method (KeratinoSensTM and/or LuSens) that models the second key event in the Adverse Outcome Pathway for Dermal Sensitization.
OECD 442E: Human Cell Line Activation Test (h-CLAT) In vitro skin sensitization test to predict skin sensitization potency.
OECD TG 492: Ocular Irritation Testing Use in vitro skin models to determine whether a product can cause dermal sensitization (e.g. EpiOcular Eye Irritation Test - EIT)
PAO Stability Trial Assess the stability of a consumer product under certain storage conditions.
Phototoxicology Phototoxicity testing identifies and evaluates the potential of chemical agents to induce toxicity upon subsequent exposure to light.
Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.
Safety In-Use Studies Safety-in-use studies assess the potential for a product to elicit adverse reactions under normal use conditions.
Sebum Production Testing to evaluate the oil production in the skin
Single Ocular Instillation Test Determine if a “tear-free” claim can be substantiated for a cosmetic product.

Other services

Cell Arrays Build, use and analyze cell-based and cell-lysate-based microarrays.
Natural Product Analysis Isolate and characterize active components of natural products.
New Request

Service areas:

DMPK Pharmacology Toxicology Clinical Manufacturing

India Bangalore, Hyderabad 2 sites

Syngene (A Biocon Company) was established in 1994 and is India’s leading CRO with multi-disciplinary skills in integrated drug discovery and development. Our capabilities include medicinal chemistry, biology, in vivo pharmacology, toxicology, custom synthesis, process R&D, cGMP manufacturing and formulation development for both small and large molecules. These services are offered on a strong platform of confidentiality and intellectual property protection. Our research facilities are certified with ISO 9001:2008, ISO 14001:2004, OHSAS 18001:2007. Our animal facilities are GLP certified...

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*Discovery Chemistry Services*-

* Medicinal Chemistry * Library Generation * Scaffold & Building Blocks Synthesis

*Process Development Services*-

* New Process Development * Optimization of existing processes * Scale up and supplies up to 10s of Kg levels

*Custom Synthesis Services*-

* Production scale up for clinical supplies * Commercial manufacturing of NCE and AIs up to 100s of Kg levels

*Analytical Services*-

* Impurity Identification, Reference Standard Qualification/Characterization * Method Development, Optimization & Validation * Intermediate & API Stability Studies * Risk Analysis * Polymorph Studies

*Polymer Chemistry & Catalysis Services*-

* Lab to Kg scale development of polymers with focus on bio-polymers and specialty polymers * Formulation Development * Development of Solid Orals h2. Biology

*Molecular Biology*

* Recombinant DNA Technology * Strain Engineering * Gene Expression * Library Construction & Screening

*Cell Line Development*

* Cell culture * cell line characterization * Research cell banking

*Protein Sciences*

* Protein Purification * Protein Characterization * Crystallography Screening

*Assay Biology*

* Assay Development and Validation * Biochemical Assays and Cell Based Assays

*Antibody Production*

* Polyclonal * Hybridoma * Recombinant Monoclonal Antibodies

*Microbiology*

* Antimicrobial Susceptibility * Mutant Generation

*ADMET & DMPK*

* Aqueous Solubility * Permeability * CYP450 Inhibition * Metabolic Stability * Plasma Protein Binding * Cytotoxicity * Pharmacokinetics

*in vivo Pharmacology*

* Oncology * Metabolic Disorders * Inflammation * Pain Models * Auto-immune Disorders * Osteoarthritis h2. Toxicology * Discovery Toxicology * Battery of Genetic Toxicology Studies * Acute, Sub-Chronic and Chronic Toxicology Studies * Developmental and Reproductive Toxicology Studies h2. Biologics * Process Development and Optimization * Scale-up and technology transfer * Pilot Scale Production (cGMP) * Formulation Development and Lyophilization * Stability Studies

Professional associations: AAPS, ACS, RSC
Website: www.syngeneintl.com

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