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CellCarta Biosciences

CellCarta Biosciences is listed as a large business research supplier in the Scientist.com network, with 6 sites in 4 countries and 2 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 6

Countries 4

Type of company: Large business

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Detection Quantitate, localize and visualize proteins and other antigens.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.

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Immunodetection Use antibodies to identify a protein or antigen.

Biomarkers

Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Complete Metabolic Panel Testing Detect electrolyte or glucose imbalance to identify or monitor related disorders.

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Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.
Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Propidium Iodide FACS Analysis Use DNA staining and flow cytometry to analyze the cell cycle and detect apoptosis or cell proliferation.
Proteocarta™ HCP Detect Services Identify and track host cell proteins (HCP) with mass spectrometry for higher sensitivity and coverage.
Single Cell Isolation Isolate single cells for subsequent single-cell analysis.
Single Cell Transcriptome Sequencing Detect distinct, rare or abnomal cell types in a heterogenous population.
Special Stainings Use a variety of techniques for the selective visualization of specific tissue or cell types.
T Cell Epitope Characterization Evaluate the potency and immunodominance of T-cell epitopes within a molecule.
Whole Transcriptome Amplification Amplify total RNA from a single cell.

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Cell Culture and Characterization

Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Sorting The purpose of cell separation is to isolate a cell population from other cells in a biological sample.
Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.
H & E Services For requesting services related to H&E Services
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.

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Microsatellite Instability Analysis Compare allelic profiles and detect genomic instability.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Single Cell DNA Sequencing Examine genetic variations in a single cell.
Single Cell Services Request services to perform genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level
Trichrome Staining Use a variety of techniques for the selective visualization of muscle, collagen fibers, fibrin and erythrocytes.

Chemical and Compound Analysis

Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Process Residual Impurities Detection Measure trace levels of impurities.

Clinical Consulting

Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.

Data Science/Bioinformatics

Biostatistical Design Use statistics to ensure appropriate pre-clinical and clinical study design.
Clinical Biomarker Analysis An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
Translational Biomarker Discovery An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.

Discovery Chemistry

LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Time of Flight Mass Cytometry (CyTOF™) Detect and quantify up to 34 different proteins simultaneously on a single-cell level.

Disease Models

Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.

DNA & RNA

Bisulfite Seq DNA Methylation Analysis Determine DNA methylation status at single-base resolution
Bisulfite Sequencing (RRBS) Analyze genome-wide methylation profiles on a single nucleotide level.
Cell Free DNA Assay Detect known mutations and discover new ones in cell-free plasma DNA.
ddPCR-Based Plasma Genotyping Perform noninvasive tumor genotyping.
Digital Polymerase Chain Reaction Obtain improved absolute target quantification and rare allele detection compared to conventional qPCR.
DNA Extraction Extract DNA from an original source.

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DNA Hydroxy Methylation Seq Use epigenetic services to analyze genome-wide DNA hydroxymethylation.
DNA Library Screening Screen genomic or cDNA libraries for positive clones.
DNA Sequencing Determine the nucleotide sequence of DNA samples.
DNA/RNA Extraction & Purification DNA/RNA Extraction & Purification.
Exome Sequencing Determine protein-coding nucleotide sequences in a DNA sample.
Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
Genotyping Examine a DNA sequence to identify specific genetic varients .
Long Read Sequencing Long read sequencing is used in genomics to sequence long fragments of DNA, enabling the ability to span complex regions of the genome.
Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
mtDNA Sequencing Use next-generation sequencing (NGS) technology to detect and analyze mitochondrial mutations.
Nanostring nCounter Use single molecule imaging to count molecules directly and without enzymatic amplification.
NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
Non-Bisulfite DNA Methylation Analysis Analyze DNA methylation by methods such as differential enzymatic cleavage or affinity capture
qPCR Analysis Measure the accumulation of PCR products in real time.
RNA Extraction Isolate total RNA or mRNA from cells or tissues
RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...
RNAscope In Situ Assays Profile single-cell gene expression in situ.
RNAseq and DNAseq library preparation and sequencing DNA/RNA sequencing and preparations
Sequence Based Methylation Analysis Detect DNA methylation sites within cytosine-phosphate-guanine (CpG) dinucleotides at single base-pair resolution.
Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
Spatial Transcriptomics Determine the sub-cellular localization of mRNA molecules. Use this to identify cellular heterogeneity in tissues, tumors, immune cells and the subcellular distribution of transcripts.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Targeted Bisulphite Sequencing Reveal changes in DNA methylation associated with nuclear reprogramming.
Targeted Sequencing/Resequencing Detect variations in a genome subset.
TCR Repertoire Sequencing Analyze the T cell receptor repertoire by means of next-generation sequencing.
Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.
Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.
Whole Genome Sequencing Determine the entire genetic make-up of an organism.

Drug Development

Cellular Immunology Consulting Immunological activities of cells in experimental or clinical situations

Human Biological Samples

Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
Human Whole Blood For requesting Human Whole Blood

In Vitro Assays

Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Cycle Assays Measure cell cycle markers and the molecular events that control cell cycle progression.

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Cell Proliferation Measure cell number, cell viability and cell division.
Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
ELISpot Assay and Testing Detect low levels of antigens.
ImmunoSEQ Assay Unmask the identity of millions of T- and B-cell receptors in a single sample using bias-controlled multiplex PCR amplification, high-throughput sequencing, and sophisticated bioinformatics.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
OnTarget™ ctDNA Analysis Detect and monitor circulating tumor DNA in blood with OnTarget™ enrichment technology.
Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.

In Vitro Pharmacology

Anaplastic lymphoma kinase (ALK) Assays Use biochemical, cell based or in vivo assays to measure ALK enzyme activity.
B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Assays Use biochemical, cell based or in vivo assays to measure CTLA-4 receptor activity.
Extracellular signal Regulated Kinase Assays Use biochemical, cell based or in vivo assays to measure ERK enzyme activity.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.

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Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
Mammalian Target of Rapamycin Complex Assays Use biochemical, cell based or in vivo assays to measure mTORC enzyme activity.
Mitogen/Extracellular signal-regulated Kinase (MEK) Assays Use biochemical, cell based or in vivo assays to measure MEK enzyme activity.
Phosphatidylinositol 3-Kinase (PI3K) Assays Use biochemical, cell based or in vivo assays to measure PI3K enzyme activity.
Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
Target Identification Identify the target(s) of a biologically active substance.
Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.

Lab Supplies, Facilities, and Equipment

Biobanking Store and track biological samples.

Protein Sciences

Antibody-Antigen Affinity Measurement Measure the binding kinetics of an antibody–antigen interaction.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.

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Protein Identification Uncover or confirm the identity of a protein.
Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Protein Sequencing Determine the amino acid sequence of protein or peptide.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.

Scientific Data Services

Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
Machine Learning/ AI Predict and model an outcome (e.g. disease progression) based on input variables (i.e. features.)
Marker Analyses Identify associations between genetic markers and traits of interest to determine markers responsible for human diseases.
Microbiome Data Analysis Determine the population composition of a microbial community and analyze its contribution to human or animal health.
Mutation Data Profiling Guide treatment decisions in cancer based on the identification of genomic mutations .
NGS: Next Generation Sequencing Data Analysis Use software to interpret data created by RNA-Seq, DNA-Seq, ChIP-Seq and DNA methylation experiments.

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Omics Informatics Consulting Services for the analysis of large-scale molecular data sets.
Pharmaco-genomics Genetic polymorphism contribution to inter-individual variability in drugs' responses and/or adverse events.
Scientific Data Visualization Exploration and reporting of data by means of graphs and plots.
Software Tools Software tool for statistical analysis, data mining, genome annotation or NGS data analysis.

Other services

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Service areas:

Biology DMPK

Canada Montreal 2 sites
United States Lake Forest, Naperville 2 sites
Belgium Antwerpen 1 site
China Jining 1 site

p<>. Through many years of practical experience, Caprion’s highly trained, multi-disciplinary team has developed a highly integrated, industrialized approach to proteomics that reduces variability and provides meaningful results. Standardized procedures from sample collection to mass spec and data analysis provide our clients reproducible data that are routinely validated across large sets of clinical samples with rapid development and deployment MRM (Multiple Reaction Monitoring) assays. p<>. Results from the many studies conducted over the past ten years has provided validation...

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p<>. Results from the many studies conducted over the past ten years has provided validation of Caprion's robust and industrialized proteomics approach to biomarker discovery and validation.

Website: www.cellcarta.com

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