Clinical trial
A 2X2X2 Factorial Randomized Phase III Trial Of Multimodality Therapy Comparing 4 Cycles Of Doxorubicin And Cyclophosphamide With Or Without Dexrazoxane (AC+/-Z) Followed By 12 Weeks Of Weekly Paclitaxel With Or Without Trastuzumab (T+/-H) Followed By Local Therapy Followed By 40 Weeks Of Weekly Trastuzumab Or None In Women With HER-2+ STAGE IIIA, IIIB OR REGIONAL STAGE IV BREAST CANCER
NCT00016276 is registered in ClinicalTrials.gov with National Cancer Institute (NCI) as lead sponsor.
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Registry record
As filed in ClinicalTrials.gov.
- Title
- A 2X2X2 Factorial Randomized Phase III Trial Of Multimodality Therapy Comparing 4 Cycles Of Doxorubicin And Cyclophosphamide With Or Without Dexrazoxane (AC+/-Z) Followed By 12 Weeks Of Weekly Paclitaxel With Or Without Trastuzumab (T+/-H) Followed By Local Therapy Followed By 40 Weeks Of Weekly Trastuzumab Or None In Women With HER-2+ STAGE IIIA, IIIB OR REGIONAL STAGE IV BREAST CANCER
- Lead sponsor
- National Cancer Institute (NCI)
- Phase
- Phase 3
- Overall status
- Terminated
- Start date
- May 31, 2001
- Completion date
- Not reported
- Enrollment
- 396 (actual)
- Sites
- 1
Conditions
As the registry lists them; a condition with its own page is linked.
cardiac toxicity, inflammatory breast cancer, stage iiia breast cancer, stage iiib breast cancer, stage iv breast cancer