A Phase I Study Of Bevacizumab (Recombinant Humanized Monoclonal Antibody To Vascular Endothelial Growth Factor) In Addition To Flourouracil And Hydroxyurea As Initial Chemotherapy With Concomitant Radiotherapy (B-FHX) For Poor Prognosis Head And Neck Cancer

Title

A Phase I Study Of Bevacizumab (Recombinant Humanized Monoclonal Antibody To Vascular Endothelial Growth Factor) In Addition To Flourouracil And Hydroxyurea As Initial Chemotherapy With Concomitant Radiotherapy (B-FHX) For Poor Prognosis Head And Neck Cancer

Lead sponsor

National Cancer Institute (NCI)

Phase

Phase 1

Overall status

Completed

Start date

July 31, 2001

Completion date

-Not reported

Enrollment

39 (actual)

Sites

1

metastatic squamous neck cancer with occult primary squamous cell carcinoma, recurrent adenoid cystic carcinoma of the oral cavity, recurrent basal cell carcinoma of the lip, recurrent esthesioneuroblastoma of the paranasal sinus and nasal cavity, recurrent inverted papilloma of the paranasal sinus and nasal cavity, recurrent lymphoepithelioma of the nasopharynx, recurrent lymphoepithelioma of the oropharynx, recurrent metastatic squamous neck cancer with occult primary, recurrent midline lethal granuloma of the paranasal sinus and nasal cavity, recurrent mucoepidermoid carcinoma of the oral cavity, recurrent salivary gland cancer, recurrent squamous cell carcinoma of the hypopharynx, recurrent squamous cell carcinoma of the larynx, recurrent squamous cell carcinoma of the lip and oral cavity, recurrent squamous cell carcinoma of the nasopharynx, recurrent squamous cell carcinoma of the oropharynx, recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity, recurrent verrucous carcinoma of the larynx, recurrent verrucous carcinoma of the oral cavity, stage iii adenoid cystic carcinoma of the oral cavity, stage iii basal cell carcinoma of the lip, stage iii esthesioneuroblastoma of the paranasal sinus and nasal cavity, stage iii inverted papilloma of the paranasal sinus and nasal cavity, stage iii lymphoepithelioma of the nasopharynx, stage iii lymphoepithelioma of the oropharynx, stage iii midline lethal granuloma of the paranasal sinus and nasal cavity, stage iii mucoepidermoid carcinoma of the oral cavity, stage iii salivary gland cancer, stage iii squamous cell carcinoma of the hypopharynx, stage iii squamous cell carcinoma of the larynx, stage iii squamous cell carcinoma of the lip and oral cavity, stage iii squamous cell carcinoma of the nasopharynx, stage iii squamous cell carcinoma of the oropharynx, stage iii squamous cell carcinoma of the paranasal sinus and nasal cavity, stage iii verrucous carcinoma of the larynx, stage iii verrucous carcinoma of the oral cavity, stage iv adenoid cystic carcinoma of the oral cavity, stage iv basal cell carcinoma of the lip, stage iv esthesioneuroblastoma of the paranasal sinus and nasal cavity, stage iv inverted papilloma of the paranasal sinus and nasal cavity, stage iv lymphoepithelioma of the nasopharynx, stage iv lymphoepithelioma of the oropharynx, stage iv midline lethal granuloma of the paranasal sinus and nasal cavity, stage iv mucoepidermoid carcinoma of the oral cavity, stage iv salivary gland cancer, stage iv squamous cell carcinoma of the hypopharynx, stage iv squamous cell carcinoma of the larynx, stage iv squamous cell carcinoma of the lip and oral cavity, stage iv squamous cell carcinoma of the nasopharynx, stage iv squamous cell carcinoma of the oropharynx, stage iv squamous cell carcinoma of the paranasal sinus and nasal cavity, stage iv verrucous carcinoma of the larynx, stage iv verrucous carcinoma of the oral cavity, untreated metastatic squamous neck cancer with occult primary