Clinical trial
An Open-label, Multicenter, Phase I Dose-escalation Trial of EGF816 and Trametinib in Patients With Non-small Cell Lung Cancer and Acquired EGFR p.T790M-positive Resistance to 1st or 2nd Generation EGFR TKI Therapy Remark: According to Version V02_0 of the Protocol, Patients May Also be Eligible if EGFR TKI-treatment naïve, EGFR p.T790M-negative at Progression While on EGFR TKI Therapy or After Progression While on Osimertinib Treatment
NCT03516214 is registered in ClinicalTrials.gov with University of Cologne as lead sponsor.
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Registry record
As filed in ClinicalTrials.gov.
- Title
- An Open-label, Multicenter, Phase I Dose-escalation Trial of EGF816 and Trametinib in Patients With Non-small Cell Lung Cancer and Acquired EGFR p.T790M-positive Resistance to 1st or 2nd Generation EGFR TKI Therapy Remark: According to Version V02_0 of the Protocol, Patients May Also be Eligible if EGFR TKI-treatment naïve, EGFR p.T790M-negative at Progression While on EGFR TKI Therapy or After Progression While on Osimertinib Treatment
- Lead sponsor
- University of Cologne
- Phase
- Phase 1
- Overall status
- Completed
- Start date
- April 25, 2018
- Completion date
- November 27, 2023
- Enrollment
- 18 (actual)
- Sites
- 7
Conditions
As the registry lists them; a condition with its own page is linked.