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Clinical trial

A Phase II/III Randomized Study of R-MiniCHOP With or Without CC-486 (Oral Azacitidine) in Participants Age 75 Years or Older With Newly Diagnosed Diffuse Large B Cell Lymphoma, Grade IIIB Follicular Lymphoma, Transformed Lymphoma, and High-Grade B-Cell Lymphomas With MYC AND BCL2 and/or BCL6 Rearrangements

NCT04799275 is registered in ClinicalTrials.gov with National Cancer Institute (NCI) as lead sponsor.

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Registry record

As filed in ClinicalTrials.gov.

Title
A Phase II/III Randomized Study of R-MiniCHOP With or Without CC-486 (Oral Azacitidine) in Participants Age 75 Years or Older With Newly Diagnosed Diffuse Large B Cell Lymphoma, Grade IIIB Follicular Lymphoma, Transformed Lymphoma, and High-Grade B-Cell Lymphomas With MYC AND BCL2 and/or BCL6 Rearrangements
Lead sponsor
National Cancer Institute (NCI)
Phase
Phase 2/3
Overall status
Active, not recruiting
Start date
May 20, 2021
Completion date
March 1, 2027
Enrollment
422 (estimated)
Sites
176

Conditions

As the registry lists them; a condition with its own page is linked.

ann arbor stage iii diffuse large b-cell lymphoma, ann arbor stage iix (bulky) diffuse large b-cell lymphoma, ann arbor stage iv diffuse large b-cell lymphoma, diffuse large b-cell lymphoma activated b-cell type, diffuse large b-cell lymphoma associated with chronic inflammation, diffuse large b-cell lymphoma germinal center b-cell type, diffuse large b-cell lymphoma, not otherwise specified, ebv-positive diffuse large b-cell lymphoma, not otherwise specified, grade 3b follicular lymphoma, hhv8-positive diffuse large b-cell lymphoma, not otherwise specified, high grade b-cell lymphoma with myc and bcl2 and/or bcl6 rearrangements, high grade b-cell lymphoma with myc and bcl2 or bcl6 rearrangements, high grade b-cell lymphoma with myc, bcl2, and bcl6 rearrangements, high grade b-cell lymphoma, not otherwise specified, intravascular large b-cell lymphoma, lymphoplasmacytic lymphoma, nodular lymphocyte predominant b-cell lymphoma, primary cutaneous diffuse large b-cell lymphoma, leg type, t-cell/histiocyte-rich large b-cell lymphoma, transformed follicular lymphoma to diffuse large b-cell lymphoma, transformed marginal zone lymphoma to diffuse large b-cell lymphoma