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Clinical trial

Randomized Phase III Trial of Neoadjuvant Immunotherapy With Response-Adapted Treatment Versus Standard-of-Care Treatment for Resectable Stage III/IV Cutaneous Squamous Cell Carcinoma (C-PRE)

NCT06568172 is registered in ClinicalTrials.gov with National Cancer Institute (NCI) as lead sponsor.

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Registry record

As filed in ClinicalTrials.gov.

Title
Randomized Phase III Trial of Neoadjuvant Immunotherapy With Response-Adapted Treatment Versus Standard-of-Care Treatment for Resectable Stage III/IV Cutaneous Squamous Cell Carcinoma (C-PRE)
Lead sponsor
National Cancer Institute (NCI)
Phase
Phase 3
Overall status
Suspended
Start date
February 18, 2025
Completion date
August 14, 2031
Enrollment
420 (estimated)
Sites
206

Conditions

As the registry lists them; a condition with its own page is linked.

eyelid squamous cell carcinoma, recurrent eyelid squamous cell carcinoma, recurrent skin acantholytic squamous cell carcinoma, recurrent skin clear cell squamous cell carcinoma, recurrent skin lymphoepithelial carcinoma, recurrent skin spindle cell squamous cell carcinoma, recurrent skin squamous cell carcinoma with sarcomatoid differentiation, resectable eyelid squamous cell carcinoma, resectable skin acantholytic squamous cell carcinoma, resectable skin clear cell squamous cell carcinoma, resectable skin lymphoepithelial carcinoma, resectable skin spindle cell squamous cell carcinoma, resectable skin squamous cell carcinoma with sarcomatoid differentiation, skin acantholytic squamous cell carcinoma, skin clear cell squamous cell carcinoma, skin lymphoepithelial carcinoma, skin spindle cell squamous cell carcinoma, skin squamous cell carcinoma with sarcomatoid differentiation, stage iii head and neck cutaneous squamous cell carcinoma ajcc v8, stage iv head and neck cutaneous squamous cell carcinoma ajcc v8