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Clinical trial

A Phase 1/2 Trial of the Doublet Combination of Avutometinib and Defactinib and as a Triplet in Combination With Temozolomide in Patients With High Grade Malignant Brain Tumours Within the 5G Platform

NCT06630260 is registered in ClinicalTrials.gov with Institute of Cancer Research, United Kingdom as lead sponsor.

NCT NCT06630260
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Registry record

As filed in ClinicalTrials.gov.

Title
A Phase 1/2 Trial of the Doublet Combination of Avutometinib and Defactinib and as a Triplet in Combination With Temozolomide in Patients With High Grade Malignant Brain Tumours Within the 5G Platform
Lead sponsor
Institute of Cancer Research, United Kingdom
Phase
Phase 1/2
Overall status
Recruiting
Start date
November 15, 2024
Completion date
September 30, 2030
Enrollment
182 (estimated)
Sites
3

Conditions

As the registry lists them; a condition with its own page is linked.

diffuse hemispheric glioma, h3 g34-mutant, glioblastoma multiform (grade iv astrocytoma), glioblastoma multiforme (gbm), malignant primary gliomas