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Clinical trial

A Phase 1, Open Label, Dose-Escalation and Expansion Study to Evaluate Safety, Pharmacokinetics and Initial Therapeutic Activity of AVA6103, a Novel FAP-activated Exatecan Administered Intravenously in Subjects With Locally Advanced or Metastatic Selected Solid Tumors

NCT07454642 is registered in ClinicalTrials.gov with Avacta Life Sciences Ltd as lead sponsor.

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Registry record

As filed in ClinicalTrials.gov.

Title
A Phase 1, Open Label, Dose-Escalation and Expansion Study to Evaluate Safety, Pharmacokinetics and Initial Therapeutic Activity of AVA6103, a Novel FAP-activated Exatecan Administered Intravenously in Subjects With Locally Advanced or Metastatic Selected Solid Tumors
Lead sponsor
Avacta Life Sciences Ltd
Phase
Phase 1
Overall status
Recruiting
Start date
March 31, 2026
Completion date
June 30, 2030
Enrollment
174 (estimated)
Sites
7

Conditions

As the registry lists them; a condition with its own page is linked.

cervical adenocarcinoma, cervical adenosquamous carcinoma, colorectal cancer, gastric adenocarcinoma, gej adenocarcinoma, hormone receptor positive breast carcinoma, pdac - pancreatic ductal adenocarcinoma, small cell carcinoma of lung, vulvar adenocarcinoma