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Clinical trial

Safety and Feasibility of First-line Avutometinib and Defactinib in Patients With Newly Diagnosed High-grade Gliomas

NCT07778602 is registered in ClinicalTrials.gov with Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins as lead sponsor.

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Registry record

As filed in ClinicalTrials.gov.

Title
Safety and Feasibility of First-line Avutometinib and Defactinib in Patients With Newly Diagnosed High-grade Gliomas
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Phase
Phase 1
Overall status
Not yet recruiting
Start date
November 10, 2026
Completion date
December 23, 2029
Enrollment
22 (estimated)
Sites
3

Conditions

As the registry lists them; a condition with its own page is linked.

idh wildtype glioblastoma, mgmt-unmethylated glioblastoma (gbm)