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Clinical trial

A Phase IIa Clinical Trial of First-Line Cyclical Gemcitabine, Cisplatin, and Durvalumab Alternating With Pemigatinib for Advanced Biliary Tract Cancers With FGFR2 Alterations

NCT07780838 is registered in ClinicalTrials.gov with Ohio State University Comprehensive Cancer Center as lead sponsor.

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Registry record

As filed in ClinicalTrials.gov.

Title
A Phase IIa Clinical Trial of First-Line Cyclical Gemcitabine, Cisplatin, and Durvalumab Alternating With Pemigatinib for Advanced Biliary Tract Cancers With FGFR2 Alterations
Lead sponsor
Ohio State University Comprehensive Cancer Center
Phase
Phase 2
Overall status
Recruiting
Start date
November 1, 2026
Completion date
December 31, 2027
Enrollment
29 (estimated)
Sites
1

Conditions

As the registry lists them; a condition with its own page is linked.

locally advanced ampulla of vater carcinoma, locally advanced biliary tract carcinoma, locally advanced extrahepatic cholangiocarcinoma, locally advanced gallbladder carcinoma, locally advanced intrahepatic cholangiocarcinoma, metastatic ampulla of vater carcinoma, metastatic biliary tract carcinoma, metastatic extrahepatic cholangiocarcinoma, metastatic gallbladder carcinoma, metastatic intrahepatic cholangiocarcinoma, stage iii ampulla of vater cancer ajcc v8, stage iii distal bile duct cancer ajcc v8, stage iii gallbladder cancer ajcc v8, stage iii intrahepatic cholangiocarcinoma ajcc v8, stage iv ampulla of vater cancer ajcc v8, stage iv distal bile duct cancer ajcc v8, stage iv gallbladder cancer ajcc v8, stage iv intrahepatic cholangiocarcinoma ajcc v8, unresectable ampulla of vater carcinoma, unresectable biliary tract carcinoma, unresectable extrahepatic cholangiocarcinoma, unresectable gallbladder carcinoma, unresectable intrahepatic cholangiocarcinoma