Condition (MeSH)
Zika Virus Infection
ClinicalTrials.gov lists 77 trials for Zika Virus Infection or a narrower condition beneath it. National Institute of Allergy and Infectious Diseases (NIAID) has the most among industry and government lead sponsors, with 12.
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Trials per phase (log scale)
77 of the 77 trials are tagged with Zika Virus Infection itself; the rest are tagged with a narrower condition beneath it.
When did Zika Virus Infection trials start? (14)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 3
- Not applicable
- Observational
Top of scale: 18
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 1 |
| 2025 | 3 |
| 2024 | 3 |
| 2023 | 2 |
| 2022 | 2 |
| 2021 | 6 |
| 2020 | 5 |
| 2019 | 6 |
| 2018 | 11 |
| 2017 | 17 |
Showing 10 of 14 earlier years.
No forecast is made for this condition: it averages 2.2 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Zika Virus Infection trials in? (5)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 21 |
| Phase 2 | 2 |
| Phase 3 | 1 |
| Not applicable | 19 |
| Observational | 34 |
How many Zika Virus Infection trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 2 |
| Enrolling by invitation | 2 |
| Completed | 58 |
| Suspended | 1 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Zika Virus Infection trials? (7)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Institute of Allergy and Infectious Diseases (NIAID) | 12 |
| Institut Pasteur | 3 |
| ModernaTX, Inc. | 3 |
| GeneOne Life Science, Inc. | 2 |
| Themis Bioscience GmbH | 2 |
Showing 5 of 7 sponsors.
Interventions as named in the registry (15)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Zika Virus Purified Inactivated Vaccine | 4 |
| VLA1601 | 2 |
| mRNA-1893 | 2 |
| GLS-5700 | 2 |
| Biological sample collection | 2 |
Showing 5 of 15 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Zika Virus Infection trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Appendicitis | 7 | 2 |
| Cellulitis | 5 | 3 |
| Depression | 3 | 2 |
| Major depression | 3 | 3 |
| Abortion spontaneous | 2 | 2 |
Showing 5 of 10 adverse events.
Which publications cover Zika Virus Infection? (106)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| School-age child neurodevelopment following antenatal Zika virus exposure. | Pediatric research | 2025 | Yes |
| Immunogenicity of a single dose of the 17DD yellow fever vaccine in a cohort of adults and children in a non-endemic area, and its association with dengue and Zika seropositivity. | PLoS neglected tropical diseases | 2025 | Yes |
| Zika in Infants and Pregnancy (ZIP) study: results from a prospective international cohort study of prenatal Zika virus infection and adverse fetal and infant outcomes. | BMC pregnancy and childbirth | 2025 | Yes |
| Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. | The Lancet. Neurology | 2024 | Yes |
| Harnessing the power of telemedicine to accomplish international pediatric outcome research during the COVID-19 pandemic. | Journal of telemedicine and telecare | 2024 | Yes |
Showing 5 of 106 publications.
Prevalence (6)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Zika virus disease | Point prevalence | Unknown | Worldwide | Not stated | Exact |
| Zika virus disease | Annual incidence | 1-5 / 10 000 | Brazil | Not stated | Unspecified |
| Zika virus disease | Point prevalence | Unknown | Worldwide | Not stated | Unspecified |
| Zika virus disease | Annual incidence | 1-5 / 10 000 | Brazil | Not stated | Exact |
| Zika virus disease | Annual incidence | 1-5 / 10 000 | Brazil | Not stated | Exact |
Showing 5 of 6 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Zika virus disease | 448237 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Zika virus disease | 448237 | Exact | Orphadata Science knowledge files, Product 1 |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.