Condition (MeSH)
Ankyloglossia
ClinicalTrials.gov lists 31 trials for Ankyloglossia or a narrower condition beneath it. Europa Life Sciences Limited has the most among industry and government lead sponsors, with 2.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase (log scale)
31 of the 31 trials are tagged with Ankyloglossia itself; the rest are tagged with a narrower condition beneath it.
When did Ankyloglossia trials start? (14)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1/2
- Not applicable
- Observational
Top of scale: 6
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 3 |
| 2025 | 2 |
| 2024 | 3 |
| 2023 | 4 |
| 2022 | 6 |
| 2021 | 1 |
| 2020 | 2 |
| 2019 | 2 |
| 2018 | 1 |
| 2015 | 1 |
Showing 10 of 14 earlier years.
No forecast is made for this condition: it averages 3.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Ankyloglossia trials in? (3)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1/2 | 1 |
| Not applicable | 22 |
| Observational | 8 |
How many Ankyloglossia trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 3 |
| Recruiting | 3 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 3 |
| Completed | 16 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Ankyloglossia trials? (2)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Europa Life Sciences Limited | 2 |
| Tel-Aviv Sourasky Medical Center | 1 |
Which drugs are being tested for Ankyloglossia? (5)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Alfentanil | 1 |
| Esmeron | 1 |
| Bovine Colostrum | 1 |
| PROPOFOL | 1 |
| Lavender Oil | 1 |
Interventions as named in the registry (4)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Sham Procedure | 2 |
| Double distilled water | 1 |
| Topical Benzocaine | 1 |
| Ibuprofen suppository | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which publications cover Ankyloglossia? (27)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Does Lingual Frenotomy Improve Breastfeeding in Newborns With Ankyloglossia? A Randomized Controlled Trial. | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | 2025 | Yes |
| Ankyloglossia and Breastfeeding Duration: A Multicenter Birth Cohort Study. | Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine | 2024 | Yes |
| Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: a randomized clinical trial (NCT04867824). | European journal of pediatrics | 2022 | Yes |
| The effect of ankyloglossia and tongue-tie division on speech articulation: A systematic review. | International journal of paediatric dentistry | 2022 | Yes |
| Systematic review of the evidence for resolution of common breastfeeding problems-Ankyloglossia (Tongue Tie). | Acta paediatrica (Oslo, Norway : 1992) | 2022 | Yes |
Showing 5 of 27 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: serious adverse events in this condition's trials, prevalence, rare-disease identity, and sub-conditions in mesh.