Condition (MeSH)
Opioid-Induced Constipation
ClinicalTrials.gov lists 84 trials for Opioid-Induced Constipation or a narrower condition beneath it.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase
84 of the 84 trials are tagged with Opioid-Induced Constipation itself; the rest are tagged with a narrower condition beneath it.
When did Opioid-Induced Constipation trials start? (24)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 12
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 1 |
| 2025 | 1 |
| 2024 | 3 |
| 2023 | 1 |
| 2022 | 3 |
| 2021 | 1 |
| 2020 | 3 |
| 2019 | 2 |
| 2018 | 3 |
| 2017 | 6 |
Showing 10 of 24 earlier years.
No forecast is made for this condition: it averages 1.8 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 3 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Opioid-Induced Constipation trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 4 |
| Phase 1/2 | 2 |
| Phase 2 | 19 |
| Phase 2/3 | 3 |
| Phase 3 | 25 |
| Phase 4 | 10 |
| Not applicable | 4 |
| Observational | 17 |
How many Opioid-Induced Constipation trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 4 |
| Completed | 60 |
| Terminated | 10 |
| Withdrawn | 1 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Opioid-Induced Constipation trials? (11)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| AstraZeneca | 9 |
| Bausch Health Americas, Inc. | 9 |
| Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 7 |
| Glycyx Therapeutics | 6 |
| Shionogi | 6 |
Showing 5 of 11 sponsors.
Which drugs are being tested for Opioid-Induced Constipation? (7)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Naloxegol | 18 |
| MOA-728 | 10 |
| Naldemedine | 8 |
| CB-5945 | 6 |
| Axelopran | 4 |
Showing 5 of 7 drugs.
Interventions as named in the registry (8)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Lubiprostone 24 | 4 |
| Targinact | 3 |
| naloxone IM | 2 |
| Tramadol 5% | 2 |
| SC MNTX | 1 |
Showing 5 of 8 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Opioid-Induced Constipation trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Disease progression | 62 | 3 |
| Malignant neoplasm progression | 28 | 2 |
| Pneumonia | 22 | 10 |
| Asthenia | 14 | 3 |
| Cellulitis | 13 | 6 |
Showing 5 of 10 adverse events.
Which publications cover Opioid-Induced Constipation? (15)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| 'Constipation': One word, many meanings amongst persons with cancer: An observational study. | Palliative medicine | 2025 | Yes |
| Opioid-induced constipation: a stepwise treatment algorithm feasibility study. | BMJ supportive & palliative care | 2023 | Yes |
| Effects of Electroacupuncture for Opioid-Induced Constipation in Patients With Cancer in China: A Randomized Clinical Trial. | JAMA network open | 2023 | Yes |
| Magnesium hydroxide versus macrogol/electrolytes in the prevention of opioid-induced constipation in incurable cancer patients: study protocol for an open-label, randomized controlled trial (the OMAMA study). | BMC palliative care | 2023 | Yes |
| Establishing Minimal Clinically Important Differences in Quality of Life Measures in Opioid-Induced Constipation. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association | 2022 | Yes |
Showing 5 of 15 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.