Condition (MeSH)
Breakthrough Infections
ClinicalTrials.gov lists 7 trials for Breakthrough Infections or a narrower condition beneath it.
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Trials per phase
7 of the 7 trials are tagged with Breakthrough Infections itself; the rest are tagged with a narrower condition beneath it.
When did Breakthrough Infections trials start? (3)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1/2
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2024 | 1 |
| 2023 | 1 |
| 2021 | 5 |
No forecast is made for this condition: it averages 0.6 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: none of the 7 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Breakthrough Infections trials in? (2)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1/2 | 1 |
| Observational | 6 |
How many Breakthrough Infections trials are recruiting? (3)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Completed | 4 |
| Unknown status | 2 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Breakthrough Infections trials? (2)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Bangkok Metropolitan Administration Medical College and Vajira Hospital | 1 |
| Pfizer | 1 |
Which serious adverse events do Breakthrough Infections trials report? (3)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Respiratory insufficiency | 4,506 | 1 |
| Hypotension | 399 | 1 |
| Acute renal failure | 144 | 1 |
Which publications cover Breakthrough Infections? (19)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Safety of Kidney Transplantation from Donors with HIV. | The New England journal of medicine | 2024 | Yes |
| Does enhanced educational intervention reduce breakthrough infection and mental health problems via improving acceptance of COVID-19 booster shots in Chinese non-healthcare workers: A randomized controlled trial? | Journal of infection and public health | 2025 | No |
| The respiratory syncytial virus prefusion F protein vaccine attenuates the severity of respiratory syncytial virus-associated disease in breakthrough infections in adults ≥60 years of age. | Influenza and other respiratory viruses | 2024 | No |
| SARS-CoV-2 Omicron infection augments the magnitude and durability of systemic and mucosal immunity in triple-dose CoronaVac recipients. | mBio | 2024 | No |
| Breakthrough infections due to SARS-CoV-2 Delta variant: relation to humoral and cellular vaccine responses. | Frontiers in immunology | 2023 | No |
Showing 5 of 19 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.
Not computed for conditions with fewer than 10 trials: drugs tested.