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Condition (MeSH)

Cytopenia

ClinicalTrials.gov lists 1,550 trials for Cytopenia or a narrower condition beneath it. Amgen has the most among industry and government lead sponsors, with 43.

MeSH D000095542 Hemic and Lymphatic Diseases C15
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Phase 1 Phase 1 134 Phase 1/2 Phase 1/2 79 Phase 2 Phase 2 373 Phase 2/3 Phase 2/3 42 Phase 3 Phase 3 241 Phase 4 Phase 4 107 Not applicable Not applicable 162 Observational Observational 404 Phase 1 Phase 1 134 Phase 1/2 Phase 1/2 79 Phase 2 Phase 2 373 Phase 2/3 Phase 2/3 42 Phase 3 Phase 3 241 Phase 4 Phase 4 107 Not applicable Not applicable 162 Observational Observational 404

Trials per phase

1 more section with rows

71 of the 1,550 trials are tagged with Cytopenia itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Cytopenia trials start? (35)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 4 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 112

1992: 1 trials (Observational 1) 1993: 4 trials (Observational 1, Phase 3 1, Phase 1 2) 1994: 3 trials (Observational 1, Phase 3 1, Phase 2 1) 1995: 7 trials (Observational 2, Not applicable 1, Phase 3 1, Phase 2 2, Phase 1 1) 1996: 5 trials (Observational 1, Phase 2 1, Phase 1 3) 1997: 3 trials (Phase 3 2, Phase 1 1) 1998: 3 trials (Phase 1/2 1, Phase 1 2) 1999: 6 trials (Phase 3 3, Phase 2 2, Phase 1 1) 2000: 15 trials (Observational 3, Not applicable 3, Phase 3 2, Phase 2/3 1, Phase 2 3, Phase 1/2 2, Phase 1 1) 2001: 12 trials (Observational 1, Not applicable 2, Phase 4 2, Phase 3 3, Phase 2 3, Phase 1 1) 2002: 22 trials (Observational 4, Not applicable 2, Phase 4 3, Phase 3 8, Phase 2 4, Phase 1/2 1) 2003: 24 trials (Observational 3, Phase 4 2, Phase 3 4, Phase 2/3 1, Phase 2 10, Phase 1/2 4) 2004: 15 trials (Observational 2, Not applicable 1, Phase 4 1, Phase 3 5, Phase 2 5, Phase 1 1) 2005: 34 trials (Observational 6, Not applicable 3, Phase 4 2, Phase 3 9, Phase 2 7, Phase 1/2 4, Phase 1 3) 2006: 33 trials (Observational 6, Phase 4 1, Phase 3 8, Phase 2/3 1, Phase 2 10, Phase 1/2 2, Phase 1 5) 2007: 42 trials (Observational 6, Not applicable 2, Phase 4 2, Phase 3 9, Phase 2 12, Phase 1/2 6, Phase 1 5) 2008: 39 trials (Observational 11, Phase 4 2, Phase 3 10, Phase 2/3 2, Phase 2 9, Phase 1/2 2, Phase 1 3) 2009: 46 trials (Observational 12, Not applicable 2, Phase 4 5, Phase 3 6, Phase 2 16, Phase 1/2 3, Phase 1 2) 2010: 55 trials (Observational 16, Not applicable 5, Phase 4 6, Phase 3 1, Phase 2/3 3, Phase 2 16, Phase 1/2 5, Phase 1 3) 2011: 54 trials (Observational 18, Not applicable 2, Phase 4 4, Phase 3 8, Phase 2 12, Phase 1/2 4, Phase 1 6) 2012: 70 trials (Observational 17, Not applicable 10, Phase 4 5, Phase 3 13, Phase 2/3 2, Phase 2 13, Phase 1/2 4, Phase 1 6) 2013: 48 trials (Observational 14, Not applicable 4, Phase 4 2, Phase 3 7, Phase 2/3 3, Phase 2 14, Phase 1/2 1, Phase 1 3) 2014: 59 trials (Observational 11, Not applicable 1, Phase 4 2, Phase 3 15, Phase 2/3 5, Phase 2 15, Phase 1/2 6, Phase 1 4) 2015: 60 trials (Observational 15, Not applicable 2, Phase 4 7, Phase 3 13, Phase 2/3 2, Phase 2 9, Phase 1/2 4, Phase 1 8) 2016: 52 trials (Observational 18, Not applicable 4, Phase 4 3, Phase 3 10, Phase 2/3 1, Phase 2 10, Phase 1/2 1, Phase 1 5) 2017: 60 trials (Observational 17, Not applicable 9, Phase 4 3, Phase 3 12, Phase 2 14, Phase 1/2 2, Phase 1 3) 2018: 69 trials (Observational 29, Not applicable 8, Phase 4 2, Phase 3 11, Phase 2/3 3, Phase 2 9, Phase 1/2 3, Phase 1 4) 2019: 72 trials (Observational 26, Not applicable 7, Phase 4 10, Phase 3 7, Phase 2/3 3, Phase 2 16, Phase 1/2 1, Phase 1 2) 2020: 69 trials (Observational 16, Not applicable 9, Phase 4 5, Phase 3 11, Phase 2 21, Phase 1 7) 2021: 86 trials (Observational 26, Not applicable 7, Phase 4 8, Phase 3 15, Phase 2/3 2, Phase 2 21, Phase 1/2 5, Phase 1 2) 2022: 84 trials (Observational 24, Not applicable 8, Phase 4 9, Phase 3 12, Phase 2/3 4, Phase 2 21, Phase 1/2 1, Phase 1 5) 2023: 86 trials (Observational 25, Not applicable 14, Phase 4 4, Phase 3 6, Phase 2/3 2, Phase 2 27, Phase 1/2 2, Phase 1 6) 2024: 84 trials (Observational 28, Not applicable 11, Phase 4 5, Phase 3 7, Phase 2/3 2, Phase 2 18, Phase 1/2 2, Phase 1 11) 2025: 112 trials (Observational 23, Not applicable 20, Phase 4 8, Phase 3 12, Phase 2/3 3, Phase 2 24, Phase 1/2 9, Phase 1 13)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 77
2025 112
2024 84
2023 86
2022 84
2021 86
2020 69
2019 72
2018 69
2017 60

Forecast of the full-year count, planned starts included, not rows of this table: about 100 trials starting in 2026 and about 110 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 159 trials still running at the 2026-10-09 snapshot; registered median of 28 months across 854 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Cytopenia trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 134
Phase 1/2 79
Phase 2 373
Phase 2/3 42
Phase 3 241
Phase 4 107
Not applicable 162
Observational 404
Expanded access 8

How many Cytopenia trials are recruiting? (12)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 81
Recruiting 212
Enrolling by invitation 6
Active, not recruiting 45
Available 4

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Cytopenia trials? (9)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Amgen 43
National Heart, Lung, and Blood Institute (NHLBI) 32
GlaxoSmithKline 29
Novartis Pharmaceuticals 27
Alexion Pharmaceuticals, Inc. 21

Which drugs are being tested for Cytopenia? (10)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Eltrombopag 86
Romiplostim 52
PEGFILGRASTIM 41
Avatrombopag 38
RITUXIMAB 33

Interventions as named in the registry (5)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Dexamethasone/Dexamethasone acetate 42
Filgrastime (G-CSF) 38
rhTPO 16
Cyclosporine 0.05% 14
Platelet Transfusion 11

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Cytopenia trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Febrile neutropenia 405 53
Pneumonia 311 70
Thrombocytopenia 225 64
Sepsis 200 63
Pyrexia 198 55

Which publications cover Cytopenia? (4)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
A pragmatic, single-arm clinical trial of a dose modification algorithm for preventing cytopenia-related delays during FOLFOX chemotherapy. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2025 Yes
Antinuclear antibody-associated autoimmune cytopenia in childhood is a risk factor for systemic lupus erythematosus. Blood 2024 Yes
Long-term outcomes of patients with refractory cytopenia of childhood under observation only. Blood advances 2025 No
Effectiveness of sirolimus for early on-set autoimmune cytopenias of autoimmune lymphoproliferative immunodeficiencies. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2025 No

Sub-conditions in MeSH (3)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages