Condition (MeSH)
Chronic Cough
ClinicalTrials.gov lists 138 trials for Chronic Cough or a narrower condition beneath it. Merck Sharp & Dohme LLC has the most among industry and government lead sponsors, with 7.
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Trials per phase
138 of the 138 trials are tagged with Chronic Cough itself; the rest are tagged with a narrower condition beneath it.
When did Chronic Cough trials start? (21)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 15
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 12 |
| 2025 | 9 |
| 2024 | 11 |
| 2023 | 10 |
| 2022 | 14 |
| 2021 | 15 |
| 2020 | 10 |
| 2019 | 5 |
| 2018 | 12 |
| 2017 | 2 |
Showing 10 of 21 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 15 trials starting in 2026 and about 13 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 27 months from start to primary completion across 9 trials still running at the 2026-10-09 snapshot; registered median of 14 months across 80 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Chronic Cough trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 13 |
| Phase 1/2 | 4 |
| Phase 2 | 29 |
| Phase 3 | 14 |
| Phase 4 | 7 |
| Not applicable | 35 |
| Observational | 36 |
How many Chronic Cough trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 9 |
| Recruiting | 24 |
| Active, not recruiting | 2 |
| Completed | 70 |
| Terminated | 10 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Chronic Cough trials? (7)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Merck Sharp & Dohme LLC | 7 |
| Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 6 |
| GlaxoSmithKline | 5 |
| Bayer | 4 |
| Bellus Health Inc. - a GSK company | 4 |
Showing 5 of 7 sponsors.
Which drugs are being tested for Chronic Cough? (7)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Gefapixant | 15 |
| BLU-5937 | 6 |
| Amitriptyline | 2 |
| Pregabalin | 2 |
| BAY1817080 | 2 |
Showing 5 of 7 drugs.
Interventions as named in the registry (8)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| data collection | 2 |
| 1% Azithromycin | 2 |
| NAL ER | 2 |
| Superior laryngeal nerve block | 2 |
| BLOOD SAMPLE | 2 |
Showing 5 of 8 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Chronic Cough trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Pneumonia | 9 | 4 |
| Asthma | 7 | 4 |
| Urosepsis | 4 | 3 |
| Bronchitis | 3 | 3 |
| COVID-19 pneumonia | 3 | 2 |
Showing 5 of 10 adverse events.
Which publications cover Chronic Cough? (16)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Effect of Behavioral Cough Suppression Therapy Delivered via Telehealth. | Journal of voice : official journal of the Voice Foundation | 2025 | Yes |
| Pulmonary Rehabilitation Exercises Effectively Improve Chronic Cough After Surgery for Non-small Cell Lung Cancer. | Cancer control : journal of the Moffitt Cancer Center | 2024 | Yes |
| Trajectories and risk factors of persistent cough after pulmonary resection: A prospective two-center study. | Thoracic cancer | 2023 | Yes |
| Camlipixant in Refractory Chronic Cough: A Phase 2b, Randomized, Placebo-controlled Trial (SOOTHE). | American journal of respiratory and critical care medicine | 2025 | No |
| Efficacy and Safety of Fexuprazan Versus Esomeprazole for Gastroesophageal Reflux Disease-Related Chronic Cough: A Randomized, Double-Blind, Active-Controlled Exploratory Trial. | Lung | 2025 | No |
Showing 5 of 16 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.