Condition (MeSH)
ACTH Syndrome, Ectopic
ClinicalTrials.gov lists 43 trials for ACTH Syndrome, Ectopic or a narrower condition beneath it. Corcept Therapeutics has the most among industry and government lead sponsors, with 9.
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Trials per phase
43 of the 43 trials are tagged with ACTH Syndrome, Ectopic itself; the rest are tagged with a narrower condition beneath it.
When did ACTH Syndrome, Ectopic trials start? (16)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 6 |
| 2025 | 1 |
| 2023 | 5 |
| 2022 | 5 |
| 2021 | 2 |
| 2020 | 3 |
| 2019 | 2 |
| 2018 | 5 |
| 2017 | 1 |
| 2016 | 2 |
Showing 10 of 16 earlier years.
No forecast is made for this condition: it averages 3.2 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 6 trials still running at the 2026-10-09 snapshot; registered median of 30 months across 22 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are ACTH Syndrome, Ectopic trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 2 |
| Phase 1/2 | 1 |
| Phase 2 | 11 |
| Phase 3 | 5 |
| Phase 4 | 4 |
| Not applicable | 7 |
| Observational | 13 |
How many ACTH Syndrome, Ectopic trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 7 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 6 |
| Completed | 17 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most ACTH Syndrome, Ectopic trials? (6)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Corcept Therapeutics | 9 |
| Novartis Pharmaceuticals | 2 |
| Sparrow Pharmaceuticals | 2 |
| Crinetics Pharmaceuticals Inc. | 1 |
| HRA Pharma | 1 |
Showing 5 of 6 sponsors.
Which drugs are being tested for ACTH Syndrome, Ectopic? (7)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Relacorilant | 5 |
| Mifepristone | 4 |
| Osilodrostat | 4 |
| SPI-62 | 2 |
| Metyrapone | 2 |
Showing 5 of 7 drugs.
Interventions as named in the registry (5)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Pasireotide s.c. | 2 |
| F18CETO | 1 |
| Intervention 2: Semaglutide | 1 |
| Synacthen infusion during adrenal venous sampling | 1 |
| Cushing's syndrome confirmation | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do ACTH Syndrome, Ectopic trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Dyspnoea | 6 | 4 |
| Hyperglycaemia | 6 | 1 |
| Hypokalaemia | 5 | 3 |
| Hypotension | 5 | 3 |
| Nausea | 5 | 2 |
Showing 5 of 10 adverse events.
Which publications cover ACTH Syndrome, Ectopic? (10)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| A role for 11C-methionine PET imaging in ACTH-dependent Cushing's syndrome. | European journal of endocrinology | 2015 | Yes |
| Prolonged remission after long-term treatment with steroidogenesis inhibitors in Cushing's syndrome caused by ectopic ACTH secretion. | European journal of endocrinology | 2012 | Yes |
| Occult ectopic secretion of corticotropin. | Archives of internal medicine | 1986 | Yes |
| Ectopic ACTH syndrome. Diagnostic and therapeutic aspects. | American journal of surgery | 1985 | Yes |
| Advances in the medical treatment of Cushing's syndrome. | The lancet. Diabetes & endocrinology | 2019 | No |
Showing 5 of 10 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.