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Condition (MeSH)

AIDS-Related Complex

ClinicalTrials.gov lists 283 trials for AIDS-Related Complex or a narrower condition beneath it. National Institute of Allergy and Infectious Diseases (NIAID) has the most among industry and government lead sponsors, with 150.

MeSH D000386 Infections C01 C12 C20
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Phase 1 Phase 1 102 Phase 2 Phase 2 56 Phase 3 Phase 3 31 Phase 4 Phase 4 1 Not applicable Not applicable 82 Observational Observational 11 Phase 1 Phase 1 102 Phase 2 Phase 2 56 Phase 3 Phase 3 31 Phase 4 Phase 4 1 Not applicable Not applicable 82 Observational Observational 11

Trials per phase (log scale)

283 of the 283 trials are tagged with AIDS-Related Complex itself; the rest are tagged with a narrower condition beneath it.

Get the AIDS-Related Complex report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did AIDS-Related Complex trials start? (9)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 2
  • Phase 3
  • Not applicable
  • Observational

Top of scale: 2

1990: 2 trials (Phase 3 1, Phase 2 1) 1994: 2 trials (Observational 1, Not applicable 1) 1995: 1 trials (Not applicable 1) 2005: 1 trials (Phase 2 1) 2008: 1 trials (Observational 1) 2009: 1 trials (Phase 3 1) 2014: 1 trials (Observational 1) 2017: 2 trials (Phase 1 2) 2021: 1 trials (Observational 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2021 1
2017 2
2014 1
2009 1
2008 1
2005 1
1995 1
1994 2
1990 2

No forecast is made for this condition: it averages 0.2 trial starts a year over the five years to September, under the 5 a year the method needs.

Recruitment duration, a model prediction: none of the 283 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are AIDS-Related Complex trials in? (6)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 102
Phase 2 56
Phase 3 31
Phase 4 1
Not applicable 82
Observational 11

How many AIDS-Related Complex trials are recruiting? (5)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Recruiting 2
Completed 270
Terminated 5
Withdrawn 4
Unknown status 2

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most AIDS-Related Complex trials? (15)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Institute of Allergy and Infectious Diseases (NIAID) 150
Glaxo Wellcome 21
Hoffmann-La Roche 11
Bristol-Myers Squibb 7
Newport Pharmaceuticals International 6

Which drugs are being tested for AIDS-Related Complex? (5)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Zidovudine 95
Zalcitabine 25
LAMIVUDINE 12
Inosine pranobex 7
Nystatin 6

Interventions as named in the registry (10)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
didanosine, ddI (drug) 32
Stavudine 12
Nevirapine IR 9
Trimethoprim / Sulfamethoxazole 8
Low-dose Aldesleukin (Proleukin®) 8

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do AIDS-Related Complex trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Death 11 1
Desaturation on BAL 4 1
Disease progression 2 1
Dyspnoea 2 1
pneumonia 2 1

Which publications cover AIDS-Related Complex? (52)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Validation of the Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria in patients undergoing percutaneous coronary intervention and comparison with contemporary bleeding risk scores. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 2020 Yes
A pooled analysis of CD4 response to zidovudine and zalcitabine treatment in patients with AIDS and AIDS-related complex. Clinical pharmacology and therapeutics 1997 Yes
Safety, pharmacokinetics, and antiviral response of CD4-immunoglobulin G by intravenous bolus in AIDS and AIDS-related complex. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1995 Yes
Pericardial effusion in AIDS. Incidence and survival. Circulation 1995 Yes
Stavudine in patients with AIDS and AIDS-related complex: AIDS clinical trials group 089. The Journal of infectious diseases 1995 Yes

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

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