Condition (MeSH)
Amelogenesis Imperfecta
ClinicalTrials.gov lists 8 trials for Amelogenesis Imperfecta or a narrower condition beneath it.
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Trials per phase
8 of the 8 trials are tagged with Amelogenesis Imperfecta itself; the rest are tagged with a narrower condition beneath it.
When did Amelogenesis Imperfecta trials start? (7)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Not applicable
- Observational
Top of scale: 2
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2025 | 1 |
| 2022 | 2 |
| 2021 | 1 |
| 2019 | 1 |
| 2016 | 1 |
| 2014 | 1 |
| 2009 | 1 |
No forecast is made for this condition: it averages 0.6 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: none of the 8 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Amelogenesis Imperfecta trials in? (2)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Not applicable | 3 |
| Observational | 5 |
How many Amelogenesis Imperfecta trials are recruiting? (4)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 2 |
| Completed | 3 |
| Terminated | 1 |
| Unknown status | 2 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which publications cover Amelogenesis Imperfecta? (9)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| SLC13A5 is the second gene associated with Kohlschütter-Tönz syndrome. | Journal of medical genetics | 2017 | Yes |
| Amelogenesis Imperfecta: 1 Family, 2 Phenotypes, and 2 Mutated Genes. | Journal of dental research | 2016 | Yes |
| Developmental defects of enamel and dentine: challenges for basic science research and clinical management. | Australian dental journal | 2014 | Yes |
| Protocol GenoDENT: Implementation of a New NGS Panel for Molecular Diagnosis of Genetic Disorders with Orodental Involvement. | Methods in molecular biology (Clifton, N.J.) | 2019 | No |
| Molar incisor hypomineralisation (MIH) training manual for clinical field surveys and practice. | European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry | 2017 | No |
Showing 5 of 9 publications.
Prevalence (12)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Amelogenesis imperfecta | Point prevalence | 1-9 / 100 000 | United States | US | Unspecified |
| Amelogenesis imperfecta | Point prevalence | 1-9 / 100 000 | United States | US | Exact |
| Amelogenesis imperfecta | Point prevalence | 1-9 / 100 000 | United States | US | Exact |
| Amelogenesis imperfecta | Point prevalence | >1 / 1000 | Sweden | Not stated | Exact |
| Amelogenesis imperfecta | Point prevalence | Unknown | Worldwide | Not stated | Exact |
Showing 5 of 12 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Amelogenesis imperfecta | 88661 | Exact | Orphadata Science knowledge files, Product 1 |
| Amelogenesis imperfecta | 88661 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: lead sponsors, serious adverse events in this condition's trials, and sub-conditions in mesh.
Not computed for conditions with fewer than 10 trials: drugs tested.