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Condition (MeSH)

Anxiety Disorders

ClinicalTrials.gov lists 8,570 trials for Anxiety Disorders or a narrower condition beneath it. National Institute of Mental Health (NIMH) has the most among industry and government lead sponsors, with 66.

MeSH D001008 Mental Disorders F03
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Phase 1 Phase 1 191 Phase 1/2 Phase 1/2 81 Phase 2 Phase 2 374 Phase 2/3 Phase 2/3 62 Phase 3 Phase 3 218 Phase 4 Phase 4 258 Not applicable Not applicable 6,160 Observational Observational 1,225 Phase 1 Phase 1 191 Phase 1/2 Phase 1/2 81 Phase 2 Phase 2 374 Phase 2/3 Phase 2/3 62 Phase 3 Phase 3 218 Phase 4 Phase 4 258 Not applicable Not applicable 6,160 Observational Observational 1,225

Trials per phase (log scale)

1 more section with rows

7,103 of the 8,570 trials are tagged with Anxiety Disorders itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Anxiety Disorders trials start? (37)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 40 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 925

1990: 1 trials (Observational 1) 1991: 2 trials (Not applicable 1, Phase 1 1) 1992: 1 trials (Phase 4 1) 1993: 3 trials (Not applicable 1, Phase 2/3 1, Phase 2 1) 1994: 1 trials (Observational 1) 1995: 4 trials (Observational 2, Not applicable 1, Phase 2 1) 1996: 5 trials (Observational 1, Not applicable 1, Phase 3 1, Phase 1 2) 1997: 8 trials (Observational 3, Phase 4 1, Phase 3 2, Phase 2/3 1, Phase 2 1) 1998: 9 trials (Observational 2, Not applicable 6, Phase 3 1) 1999: 5 trials (Observational 1, Phase 3 2, Phase 2/3 1, Phase 2 1) 2000: 16 trials (Observational 1, Not applicable 5, Phase 4 5, Phase 2/3 3, Phase 2 2) 2001: 28 trials (Observational 6, Not applicable 6, Phase 4 2, Phase 3 7, Phase 2/3 1, Phase 2 4, Phase 1/2 2) 2002: 50 trials (Observational 6, Not applicable 12, Phase 4 9, Phase 3 4, Phase 2/3 3, Phase 2 9, Phase 1/2 3, Phase 1 4) 2003: 49 trials (Observational 7, Not applicable 14, Phase 4 6, Phase 3 10, Phase 2/3 3, Phase 2 7, Phase 1 2) 2004: 71 trials (Observational 6, Not applicable 19, Phase 4 13, Phase 3 15, Phase 2/3 3, Phase 2 9, Phase 1/2 1, Phase 1 5) 2005: 74 trials (Observational 8, Not applicable 18, Phase 4 12, Phase 3 14, Phase 2/3 2, Phase 2 14, Phase 1/2 2, Phase 1 4) 2006: 115 trials (Observational 16, Not applicable 30, Phase 4 17, Phase 3 23, Phase 2 15, Phase 1/2 2, Phase 1 12) 2007: 105 trials (Observational 18, Not applicable 38, Phase 4 12, Phase 3 7, Phase 2/3 3, Phase 2 16, Phase 1/2 2, Phase 1 9) 2008: 153 trials (Observational 17, Not applicable 60, Phase 4 15, Phase 3 20, Phase 2/3 4, Phase 2 21, Phase 1/2 4, Phase 1 12) 2009: 124 trials (Observational 16, Not applicable 53, Phase 4 16, Phase 3 10, Phase 2 15, Phase 1/2 4, Phase 1 10) 2010: 142 trials (Observational 23, Not applicable 66, Phase 4 12, Phase 3 9, Phase 2/3 3, Phase 2 16, Phase 1/2 4, Phase 1 9) 2011: 149 trials (Observational 20, Not applicable 79, Phase 4 7, Phase 3 9, Phase 2/3 6, Phase 2 17, Phase 1/2 4, Phase 1 7) 2012: 170 trials (Observational 21, Not applicable 96, Phase 4 9, Phase 3 10, Phase 2/3 1, Phase 2 23, Phase 1/2 5, Phase 1 5) 2013: 160 trials (Observational 24, Not applicable 99, Phase 4 10, Phase 3 9, Phase 2/3 1, Phase 2 10, Phase 1/2 3, Phase 1 4) 2014: 212 trials (Observational 28, Not applicable 152, Phase 4 12, Phase 3 1, Phase 2/3 2, Phase 2 11, Phase 1/2 2, Phase 1 4) 2015: 245 trials (Observational 21, Not applicable 179, Phase 4 11, Phase 3 6, Phase 2/3 4, Phase 2 14, Phase 1/2 5, Phase 1 5) 2016: 260 trials (Observational 31, Not applicable 196, Phase 4 7, Phase 3 3, Phase 2/3 2, Phase 2 11, Phase 1/2 2, Phase 1 8) 2017: 289 trials (Observational 32, Not applicable 222, Phase 4 12, Phase 3 4, Phase 2/3 2, Phase 2 9, Phase 1/2 6, Phase 1 2) 2018: 399 trials (Observational 69, Not applicable 300, Phase 4 8, Phase 3 1, Phase 2/3 4, Phase 2 9, Phase 1/2 2, Phase 1 6) 2019: 445 trials (Observational 72, Not applicable 342, Phase 4 9, Phase 3 3, Phase 2/3 1, Phase 2 5, Phase 1/2 3, Phase 1 10) 2020: 551 trials (Observational 162, Not applicable 361, Phase 4 6, Phase 3 5, Phase 2 8, Phase 1/2 3, Phase 1 6) 2021: 716 trials (Observational 101, Not applicable 560, Phase 4 9, Phase 3 11, Phase 2/3 2, Phase 2 20, Phase 1/2 6, Phase 1 7) 2022: 658 trials (Observational 82, Not applicable 526, Phase 4 8, Phase 3 3, Phase 2/3 1, Phase 2 21, Phase 1/2 5, Phase 1 12) 2023: 776 trials (Observational 97, Not applicable 636, Phase 4 8, Phase 3 7, Phase 2/3 3, Phase 2 11, Phase 1/2 2, Phase 1 12) 2024: 894 trials (Observational 120, Not applicable 722, Phase 4 3, Phase 3 5, Phase 2/3 2, Phase 2 25, Phase 1/2 3, Phase 1 14) 2025: 925 trials (Observational 115, Not applicable 750, Phase 4 8, Phase 3 4, Phase 2/3 2, Phase 2 31, Phase 1/2 2, Phase 1 13)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 698
2025 925
2024 894
2023 776
2022 658
2021 716
2020 551
2019 445
2018 399
2017 289

Forecast of the full-year count, planned starts included, not rows of this table: about 900 trials starting in 2026 and about 890 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 10 percent and ran about 4 percent high against the count later registered; forecasts made before the year began were off by about 25 percent and ran about 15 percent low against the count later registered, and had about 7 percent more error than repeating last year's count. The part-way figures are from forecasts that used a multiple fitted only on earlier years. A stricter check that trains only on older years did not support adding planned starts for conditions of this size: it ran about 6 percent high against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 33 months from start to primary completion across 888 trials still running at the 2026-10-09 snapshot; registered median of 13 months across 5,316 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Anxiety Disorders trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 191
Phase 1/2 81
Phase 2 374
Phase 2/3 62
Phase 3 218
Phase 4 258
Not applicable 6,160
Observational 1,225
Expanded access 1

How many Anxiety Disorders trials are recruiting? (10)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 587
Recruiting 976
Enrolling by invitation 133
Active, not recruiting 280
Completed 5,007

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Anxiety Disorders trials? (2)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Institute of Mental Health (NIMH) 66
VA Office of Research and Development 54

Which drugs are being tested for Anxiety Disorders? (4)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
PMI-150 (intranasal ketamine) 29
D-Cycloserine 25
CBT 23
Duloxetine 20

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Treatment As Usual 101
Control (placebo) group 57
Sertralin 45
Escitalopram Pill 45
D. Midazolam 43

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Anxiety Disorders trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Serious Adverse Event 91 2
Suicidal ideation 91 13
Hospitalization 49 8
Miscarriage 38 2
Dizziness 24 2

Which publications cover Anxiety Disorders? (3,148)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (7)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages