Condition (MeSH)
Arnold-Chiari Malformation
ClinicalTrials.gov lists 34 trials for Arnold-Chiari Malformation or a narrower condition beneath it. National Institute of Neurological Disorders and Stroke (NINDS) has the most among industry and government lead sponsors, with 3.
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Trials per phase
34 of the 34 trials are tagged with Arnold-Chiari Malformation itself; the rest are tagged with a narrower condition beneath it.
When did Arnold-Chiari Malformation trials start? (18)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 2
- Phase 3
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 2 |
| 2024 | 3 |
| 2023 | 5 |
| 2022 | 1 |
| 2020 | 2 |
| 2019 | 3 |
| 2018 | 1 |
| 2017 | 5 |
| 2016 | 1 |
| 2015 | 2 |
Showing 10 of 18 earlier years.
No forecast is made for this condition: it averages 2.2 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 2 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Arnold-Chiari Malformation trials in? (4)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 2 | 1 |
| Phase 3 | 1 |
| Not applicable | 18 |
| Observational | 14 |
How many Arnold-Chiari Malformation trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 3 |
| Recruiting | 2 |
| Enrolling by invitation | 2 |
| Active, not recruiting | 2 |
| Completed | 16 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Arnold-Chiari Malformation trials? (2)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Institute of Neurological Disorders and Stroke (NINDS) | 3 |
| Aesculap AG | 1 |
Interventions as named in the registry (4)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| MRI | 2 |
| Exercise | 1 |
| BLOOD SAMPLE | 1 |
| A3: Acetaminophen (Tylenol caplets®, from Janssen-Cilag, S.A. de C.V.) | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Arnold-Chiari Malformation trials report? (1)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| CSF leak | 2 | 1 |
Which publications cover Arnold-Chiari Malformation? (63)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Natural history of Chiari I malformation-syringomyelia: longitudinal cohort study. | Journal of neurology, neurosurgery, and psychiatry | 2025 | Yes |
| Cerebrospinal Fluid Hydrodynamics in Chiari I Malformation and Syringomyelia: Modeling Pathophysiology. | Neurosurgery clinics of North America | 2023 | Yes |
| A novel scoring system for assessing adult syringomyelia associated with CM I treatment outcomes. | Acta neurologica Belgica | 2023 | Yes |
| Prevalence of Chiari malformation type 1 is increased in pseudohypoparathyroidism type 1A and associated with aberrant bone development. | PloS one | 2023 | Yes |
| Postural control in Chiari I malformation: protocol for a paediatric prospective, observational cohort - potential role of posturography for surgical indication. | BMJ open | 2022 | Yes |
Showing 5 of 63 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.