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Condition (MeSH)

Atrial Flutter

ClinicalTrials.gov lists 206 trials for Atrial Flutter or a narrower condition beneath it. Boston Scientific Corporation has the most among industry and government lead sponsors, with 8.

MeSH D001282 Cardiovascular Diseases C14 C23
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Phase 1 Phase 1 1 Phase 2 Phase 2 12 Phase 2/3 Phase 2/3 4 Phase 3 Phase 3 23 Phase 4 Phase 4 22 Not applicable Not applicable 86 Observational Observational 57 Unknown Unknown 1 Phase 1 Phase 1 1 Phase 2 Phase 2 12 Phase 2/3 Phase 2/3 4 Phase 3 Phase 3 23 Phase 4 Phase 4 22 Not applicable Not applicable 86 Observational Observational 57 Unknown Unknown 1

Trials per phase (log scale)

206 of the 206 trials are tagged with Atrial Flutter itself; the rest are tagged with a narrower condition beneath it.

Get the Atrial Flutter report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Atrial Flutter trials start? (26)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Unknown

Top of scale: 21

1999: 1 trials (Phase 3 1) 2001: 3 trials (Phase 4 1, Phase 3 2) 2003: 3 trials (Phase 4 2, Phase 2/3 1) 2004: 9 trials (Phase 4 1, Phase 3 6, Phase 2/3 2) 2005: 8 trials (Observational 4, Not applicable 2, Phase 3 1, Phase 2 1) 2006: 5 trials (Phase 4 3, Phase 3 1, Phase 2 1) 2007: 1 trials (Not applicable 1) 2008: 5 trials (Not applicable 1, Phase 4 1, Phase 3 1, Phase 2/3 1, Phase 2 1) 2009: 4 trials (Not applicable 1, Phase 3 3) 2010: 9 trials (Observational 3, Not applicable 5, Phase 2 1) 2011: 2 trials (Not applicable 1, Phase 2 1) 2012: 9 trials (Observational 2, Not applicable 3, Phase 4 2, Phase 3 1, Phase 2 1) 2013: 10 trials (Observational 2, Not applicable 4, Phase 4 3, Phase 2 1) 2014: 12 trials (Observational 4, Not applicable 3, Phase 3 2, Phase 2 2, Phase 1 1) 2015: 9 trials (Observational 3, Not applicable 6) 2016: 6 trials (Observational 1, Not applicable 5) 2017: 10 trials (Observational 4, Not applicable 6) 2018: 17 trials (Unknown 1, Observational 6, Not applicable 7, Phase 4 1, Phase 3 2) 2019: 6 trials (Observational 3, Not applicable 1, Phase 4 2) 2020: 11 trials (Observational 4, Not applicable 5, Phase 4 2) 2021: 12 trials (Observational 6, Not applicable 6) 2022: 8 trials (Observational 4, Not applicable 4) 2023: 8 trials (Observational 2, Not applicable 4, Phase 4 2) 2024: 21 trials (Observational 5, Not applicable 12, Phase 4 1, Phase 2 3) 2025: 8 trials (Observational 2, Not applicable 5, Phase 3 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 9
2025 8
2024 21
2023 8
2022 8
2021 12
2020 11
2019 6
2018 17
2017 10

Forecast of the full-year count, planned starts included, not rows of this table: about 8 trials starting in 2026 and about 10 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored. The 2026 forecast is below the 9 already registered with a 2026 start date: at the cutoff, 3 trials were already registered to start in October to December, more than the method's monthly average allows for, and the method does not use those planned starts.

Prediction, not a registry value: median of 35 months from start to primary completion across 20 trials still running at the 2026-10-09 snapshot; registered median of 26 months across 127 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Atrial Flutter trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 1
Phase 2 12
Phase 2/3 4
Phase 3 23
Phase 4 22
Not applicable 86
Observational 57
Unknown 1

How many Atrial Flutter trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 9
Recruiting 26
Enrolling by invitation 2
Active, not recruiting 10
Completed 109

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Atrial Flutter trials? (8)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Boston Scientific Corporation 8
Sanofi 5
Adagio Medical 3
Bristol-Myers Squibb 3
Medtronic Cardiac Ablation Solutions 3

Which drugs are being tested for Atrial Flutter? (7)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
DRONEDARONE 3
Tedisamil sesquifumarate 3
Vernakalant 2
Rivaroxaban 2
CELIVARONE (SSR149744C) 2

Interventions as named in the registry (8)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
2% Diltiazem 4
Apixaban IR 4
amiodarone amiodarone 4
BIBR 1048 low1 3
Warfarin VKA 3

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Atrial Flutter trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Cardiac failure 622 3
Atrial fibrillation 590 2
Pneumonia 518 7
Cardiac failure congestive 359 4
Congestive heart failure 263 1

Which publications cover Atrial Flutter? (242)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation: The DECAF Randomized Clinical Trial. JAMA 2026 Yes
Dronedarone provides effective early rhythm control: post-hoc analysis of the ATHENA trial using EAST-AFNET 4 criteria. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2025 Yes
Very high-power short-duration radiofrequency ablation in patients with typical atrial flutter: rationale and design of the FASD-HP randomized trial. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2025 Yes
External validation of a machine learning-based classification algorithm for ambulatory heart rhythm diagnostics in pericardioversion atrial fibrillation patients using smartphone photoplethysmography: the SMARTBEATS-ALGO study. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2025 Yes
RAFF-5 Study to Improve the Quality and Safety of Care for Patients Seen in the Emergency Department With Acute Atrial Fibrillation and Flutter. The Canadian journal of cardiology 2024 Yes

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

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