Condition (MeSH)
Barotrauma
ClinicalTrials.gov lists 54 trials for Barotrauma or a narrower condition beneath it. VA Office of Research and Development has the most among industry and government lead sponsors, with 3.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase (log scale)
15 of the 54 trials are tagged with Barotrauma itself; the rest are tagged with a narrower condition beneath it.
When did Barotrauma trials start? (18)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 2/3
- Phase 3
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 6 |
| 2025 | 4 |
| 2024 | 3 |
| 2023 | 5 |
| 2022 | 1 |
| 2021 | 4 |
| 2020 | 4 |
| 2018 | 1 |
| 2017 | 4 |
| 2016 | 2 |
Showing 10 of 18 earlier years.
No forecast is made for this condition: it averages 3.8 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 4 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Barotrauma trials in? (6)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 2 |
| Phase 2/3 | 2 |
| Phase 3 | 1 |
| Not applicable | 18 |
| Observational | 30 |
How many Barotrauma trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 5 |
| Recruiting | 8 |
| Enrolling by invitation | 1 |
| Completed | 33 |
| Suspended | 1 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Barotrauma trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| VA Office of Research and Development | 3 |
| US Department of Veterans Affairs | 2 |
| BioAegis Therapeutics Inc. | 1 |
Which drugs are being tested for Barotrauma? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Medical Air | 1 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Medicinal gas - oxygen (Nippon Gases 200 bar) | 2 |
| PBR28 TSPO PET | 1 |
| Hyperbaric Oxygen | 1 |
| Sodium Chloride 0.9% Inj pre-exposure | 1 |
| Recombinant human plasma gelsolin pre-exposure | 1 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which publications cover Barotrauma? (71)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Extracorporeal membrane oxygenation for prevention of barotrauma in patients with respiratory failure: A scoping review. | Artificial organs | 2025 | Yes |
| Ventilatory associated barotrauma in COVID-19 patients: A multicenter observational case control study (COVI-MIX-study). | Pulmonology | 2023 | Yes |
| Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review. | Respiratory medicine | 2023 | Yes |
| The Macklin effect closely correlates with pneumomediastinum in acutely ill intubated patients with COVID-19 infection. | Clinical imaging | 2023 | Yes |
| Venovenous Extracorporeal Membrane Oxygenation in Awake Non-Intubated Patients With COVID-19 ARDS at High Risk for Barotrauma. | Journal of cardiothoracic and vascular anesthesia | 2022 | Yes |
Showing 5 of 71 publications.
Sub-conditions in MeSH (2)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: serious adverse events in this condition's trials, prevalence, and rare-disease identity.