Condition (MeSH)
Intracranial Arteriosclerosis
ClinicalTrials.gov lists 279 trials for Intracranial Arteriosclerosis or a narrower condition beneath it. Hopeful Aging has the most among industry and government lead sponsors, with 6.
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Trials per phase (log scale)
98 of the 279 trials are tagged with Intracranial Arteriosclerosis itself; the rest are tagged with a narrower condition beneath it.
When did Intracranial Arteriosclerosis trials start? (30)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 24
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 5 |
| 2025 | 17 |
| 2024 | 21 |
| 2023 | 24 |
| 2022 | 20 |
| 2021 | 21 |
| 2020 | 22 |
| 2019 | 19 |
| 2018 | 14 |
| 2017 | 12 |
Showing 10 of 30 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 7 trials starting in 2026 and about 13 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 26 trials still running at the 2026-10-09 snapshot; registered median of 35 months across 125 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Intracranial Arteriosclerosis trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 6 |
| Phase 1/2 | 2 |
| Phase 2 | 20 |
| Phase 2/3 | 7 |
| Phase 3 | 28 |
| Phase 4 | 21 |
| Not applicable | 97 |
| Observational | 98 |
How many Intracranial Arteriosclerosis trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 14 |
| Recruiting | 53 |
| Enrolling by invitation | 2 |
| Active, not recruiting | 12 |
| Completed | 122 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Intracranial Arteriosclerosis trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Hopeful Aging | 6 |
| Eisai Inc. | 3 |
| National Heart, Lung, and Blood Institute (NHLBI) | 3 |
Which drugs are being tested for Intracranial Arteriosclerosis? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| ATORVASTATIN | 3 |
| Alirocumab | 3 |
| Rivaroxaban | 2 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| EC Aspirin | 4 |
| Galantamine ER | 4 |
| Donepezil HCI (drug) | 4 |
| IR Risperidone | 3 |
| Statin | 2 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Intracranial Arteriosclerosis trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Overnight hospitalization | 334 | 1 |
| Severe fall | 83 | 1 |
| Hospitalizations and Emergency Room Visits | 20 | 1 |
| Cerebrovascular accident | 15 | 3 |
| Death | 7 | 2 |
Showing 5 of 10 adverse events.
Which publications cover Intracranial Arteriosclerosis? (222)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Comparison of drug-coated balloon with bare-metal stent in patients with symptomatic intracranial atherosclerotic stenosis: the AcoArt sICAS randomized clinical trial. | Journal of neurointerventional surgery | 2026 | Yes |
| Stenting versus medical treatment alone for symptomatic intracranial artery stenosis: a preplanned pooled individual patient data analysis. | Journal of neurointerventional surgery | 2025 | Yes |
| Advancements in imaging of intracranial atherosclerotic disease: beyond the arterial lumen to the vessel wall. | Reviews in the neurosciences | 2025 | Yes |
| Combination Antithrombotic Therapy for Reduction of Recurrent Ischemic Stroke in Intracranial Atherosclerotic Disease. | Stroke | 2025 | Yes |
| Evaluation of Intensive Statins and Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors on Intracranial Artery Plaque Stability: A Prospective Single-Arm Study. | Journal of the American Heart Association | 2025 | Yes |
Showing 5 of 222 publications.
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.