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Condition (MeSH)

Dentin Sensitivity

ClinicalTrials.gov lists 284 trials for Dentin Sensitivity or a narrower condition beneath it. GlaxoSmithKline has the most among industry and government lead sponsors, with 28.

MeSH D003807 Stomatognathic Diseases C07
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Phase 1 Phase 1 10 Phase 1/2 Phase 1/2 4 Phase 2 Phase 2 13 Phase 2/3 Phase 2/3 8 Phase 3 Phase 3 22 Phase 4 Phase 4 21 Not applicable Not applicable 198 Observational Observational 8 Phase 1 Phase 1 10 Phase 1/2 Phase 1/2 4 Phase 2 Phase 2 13 Phase 2/3 Phase 2/3 8 Phase 3 Phase 3 22 Phase 4 Phase 4 21 Not applicable Not applicable 198 Observational Observational 8

Trials per phase (log scale)

284 of the 284 trials are tagged with Dentin Sensitivity itself; the rest are tagged with a narrower condition beneath it.

Get the Dentin Sensitivity report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Dentin Sensitivity trials start? (21)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 38

2006: 1 trials (Not applicable 1) 2007: 1 trials (Observational 1) 2008: 3 trials (Not applicable 1, Phase 4 1, Phase 3 1) 2009: 3 trials (Not applicable 1, Phase 2/3 1, Phase 2 1) 2010: 1 trials (Not applicable 1) 2011: 5 trials (Observational 1, Not applicable 3, Phase 4 1) 2012: 9 trials (Not applicable 5, Phase 3 3, Phase 2 1) 2013: 5 trials (Not applicable 3, Phase 4 1, Phase 3 1) 2014: 13 trials (Not applicable 9, Phase 4 2, Phase 2/3 1, Phase 2 1) 2015: 13 trials (Observational 1, Not applicable 10, Phase 3 1, Phase 2 1) 2016: 27 trials (Not applicable 16, Phase 4 6, Phase 3 3, Phase 2 1, Phase 1 1) 2017: 14 trials (Not applicable 9, Phase 3 2, Phase 2 1, Phase 1 2) 2018: 17 trials (Observational 1, Not applicable 12, Phase 3 1, Phase 2/3 1, Phase 2 1, Phase 1 1) 2019: 13 trials (Not applicable 9, Phase 4 2, Phase 3 1, Phase 2 1) 2020: 16 trials (Not applicable 10, Phase 4 1, Phase 3 1, Phase 2/3 3, Phase 1/2 1) 2021: 16 trials (Not applicable 10, Phase 4 3, Phase 2 1, Phase 1/2 2) 2022: 12 trials (Not applicable 10, Phase 4 1, Phase 1 1) 2023: 26 trials (Not applicable 23, Phase 4 1, Phase 2 1, Phase 1 1) 2024: 34 trials (Observational 2, Not applicable 24, Phase 4 1, Phase 3 2, Phase 2 3, Phase 1 2) 2025: 38 trials (Observational 1, Not applicable 27, Phase 3 5, Phase 2/3 2, Phase 1/2 1, Phase 1 2)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 17
2025 38
2024 34
2023 26
2022 12
2021 16
2020 16
2019 13
2018 17
2017 14

Forecast of the full-year count, planned starts included, not rows of this table: about 25 trials starting in 2026 and about 32 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 19 months from start to primary completion across 15 trials still running at the 2026-10-09 snapshot; registered median of 5 months across 210 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Dentin Sensitivity trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 10
Phase 1/2 4
Phase 2 13
Phase 2/3 8
Phase 3 22
Phase 4 21
Not applicable 198
Observational 8

How many Dentin Sensitivity trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 17
Recruiting 13
Enrolling by invitation 5
Active, not recruiting 8
Completed 205

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Dentin Sensitivity trials? (6)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
GlaxoSmithKline 28
HALEON 20
Procter and Gamble 11
Colgate Palmolive 6
Pakistan Institute of Medical Sciences 6

Which drugs are being tested for Dentin Sensitivity? (4)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Stannous Fluoride 19
Biotene 12
Potassium Nitrate Toothpaste 6
Propolis 4

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Fluoride Varnish 9
Fluoride Toothpaste 6
Gluma Desensitizer 5
Fluoride 5
Sodium monofluorophosphate dentifrice 4

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Dentin Sensitivity trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Tooth Sensitivity (Score of >3) 77 1
Cholecystitis 2 2
Syncope 2 2
Anxiety 1 1
Head Injury 1 1

Which publications cover Dentin Sensitivity? (307)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

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