Condition (MeSH)
Epilepsy, Tonic-Clonic
ClinicalTrials.gov lists 23 trials for Epilepsy, Tonic-Clonic or a narrower condition beneath it.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase
23 of the 23 trials are tagged with Epilepsy, Tonic-Clonic itself; the rest are tagged with a narrower condition beneath it.
When did Epilepsy, Tonic-Clonic trials start? (17)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 2
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2025 | 2 |
| 2024 | 1 |
| 2022 | 2 |
| 2021 | 2 |
| 2020 | 2 |
| 2018 | 2 |
| 2017 | 1 |
| 2011 | 1 |
| 2009 | 1 |
| 2007 | 1 |
Showing 10 of 17 earlier years.
No forecast is made for this condition: it averages 1.2 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Epilepsy, Tonic-Clonic trials in? (5)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 3 | 9 |
| Phase 4 | 3 |
| Not applicable | 7 |
| Observational | 3 |
How many Epilepsy, Tonic-Clonic trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 2 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 1 |
| Completed | 16 |
| Terminated | 2 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Epilepsy, Tonic-Clonic trials? (10)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| GlaxoSmithKline | 3 |
| Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 3 |
| LivaNova | 2 |
| Eisai Limited | 1 |
| EpiWatch, Inc. | 1 |
Showing 5 of 10 sponsors.
Which drugs are being tested for Epilepsy, Tonic-Clonic? (4)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Fenfluramine | 1 |
| Phenytoin | 1 |
| Fosphenytoin | 1 |
| Perampanel | 1 |
Interventions as named in the registry (7)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Topiramate IR | 4 |
| Levetiracetam XR | 4 |
| Lamotrigine use | 2 |
| Topamax® coated tablet | 1 |
| Oral Zonisamide Therapy | 1 |
Showing 5 of 7 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Epilepsy, Tonic-Clonic trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Abdominal pain | 1 | 1 |
| Abortion spontaneous | 1 | 1 |
| Altered state of consciousness | 1 | 1 |
| Ataxia | 1 | 1 |
| Bile duct cancer | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Epilepsy, Tonic-Clonic? (45)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Multimodal nocturnal seizure detection in children with epilepsy: A prospective, multicenter, long-term, in-home trial. | Epilepsia | 2023 | Yes |
| A case report of several intraoperative convulsions while using the Narcotrend monitor: Significance and predictive use. | Medicine | 2019 | Yes |
| Efficacy, safety, and tolerability of adjunctive brivaracetam for secondarily generalized tonic-clonic seizures: Pooled results from three Phase III studies. | Epilepsy research | 2016 | Yes |
| Tracking generalized tonic-clonic seizures with a wrist accelerometer linked to an online database. | Seizure | 2016 | Yes |
| [Severe local anesthetic intoxication in an infant undergoing circumcision]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie | 2015 | Yes |
Showing 5 of 45 publications.
Prevalence (1)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Epilepsy with generalized tonic-clonic seizures alone | Point prevalence | Unknown | Worldwide | Not stated | Unspecified |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: rare-disease identity and sub-conditions in mesh.