Condition (MeSH)
Epilepsy, Generalized
ClinicalTrials.gov lists 236 trials for Epilepsy, Generalized or a narrower condition beneath it. Jazz Pharmaceuticals has the most among industry and government lead sponsors, with 10.
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Trials per phase
1 more section with rows
37 of the 236 trials are tagged with Epilepsy, Generalized itself; the rest are tagged with a narrower condition beneath it.
When did Epilepsy, Generalized trials start? (31)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
- Other (Expanded access)
Top of scale: 21
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 8 |
| 2025 | 18 |
| 2024 | 21 |
| 2023 | 12 |
| 2022 | 19 |
| 2021 | 16 |
| 2020 | 13 |
| 2019 | 10 |
| 2018 | 14 |
| 2017 | 13 |
Showing 10 of 31 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 11 trials starting in 2026 and about 16 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 28 trials still running at the 2026-10-09 snapshot; registered median of 25 months across 132 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Epilepsy, Generalized trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 11 |
| Phase 1/2 | 13 |
| Phase 2 | 27 |
| Phase 2/3 | 11 |
| Phase 3 | 59 |
| Phase 4 | 13 |
| Not applicable | 30 |
| Observational | 63 |
| Expanded access | 9 |
How many Epilepsy, Generalized trials are recruiting? (12)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 5 |
| Recruiting | 30 |
| Enrolling by invitation | 3 |
| Active, not recruiting | 15 |
| Available | 3 |
Showing 5 of 12 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Epilepsy, Generalized trials? (10)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Jazz Pharmaceuticals | 10 |
| Takeda | 7 |
| Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 6 |
| Lady Hardinge Medical College | 5 |
| Longboard Pharmaceuticals | 5 |
Showing 5 of 10 sponsors.
Which drugs are being tested for Epilepsy, Generalized? (8)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Cannabidiol | 17 |
| Fenfluramine | 8 |
| Vigabatrin | 7 |
| Soticlestat | 5 |
| ZX008 (Fenfluramine Hydrochloride) | 5 |
Showing 5 of 8 drugs.
Interventions as named in the registry (7)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Levetiracetam XR | 9 |
| Topiramate IR | 8 |
| Brivaracetam bolus | 4 |
| Lamotrigine use | 3 |
| ETX101 | 3 |
Showing 5 of 7 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Epilepsy, Generalized trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Status epilepticus | 188 | 19 |
| Pneumonia | 130 | 17 |
| Seizure | 105 | 13 |
| Convulsion | 98 | 9 |
| Pyrexia | 45 | 11 |
Showing 5 of 10 adverse events.
Which publications cover Epilepsy, Generalized? (93)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Efficacy of treating Helicobacter pylori infection on seizure frequency in children with drug-resistant idiopathic generalized epilepsy: a randomized controlled trial. | Italian journal of pediatrics | 2025 | Yes |
| Long-term tolerability and efficacy of adjunctive brivaracetam in pediatric patients with generalized-onset seizures: Subgroup analysis of an open-label, follow-up trial. | Epilepsy & behavior : E&B | 2025 | Yes |
| Pentoxifylline as Adjuvant Therapy in Patients with Generalized Epilepsy Treated with Phenytoin: A Randomized Controlled Study. | Molecular neurobiology | 2025 | Yes |
| Bi-allelic variants in SNF8 cause a disease spectrum ranging from severe developmental and epileptic encephalopathy to syndromic optic atrophy. | American journal of human genetics | 2024 | Yes |
| Long-term safety and efficacy of adjunctive lacosamide in the treatment of generalized onset tonic-clonic seizures: An open-label extension trial. | Epilepsia | 2024 | Yes |
Showing 5 of 93 publications.
Sub-conditions in MeSH (5)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.