Condition (MeSH)
Spasms, Infantile
ClinicalTrials.gov lists 47 trials for Spasms, Infantile or a narrower condition beneath it. Lady Hardinge Medical College has the most among industry and government lead sponsors, with 5.
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Trials per phase
47 of the 47 trials are tagged with Spasms, Infantile itself; the rest are tagged with a narrower condition beneath it.
When did Spasms, Infantile trials start? (20)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 1 |
| 2025 | 4 |
| 2024 | 3 |
| 2023 | 3 |
| 2022 | 3 |
| 2021 | 2 |
| 2020 | 2 |
| 2019 | 3 |
| 2018 | 3 |
| 2017 | 5 |
Showing 10 of 20 earlier years.
No forecast is made for this condition: it averages 3.0 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 9 trials still running at the 2026-10-09 snapshot; registered median of 21 months across 25 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Spasms, Infantile trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 9 |
| Phase 2/3 | 7 |
| Phase 3 | 10 |
| Phase 4 | 3 |
| Not applicable | 5 |
| Observational | 10 |
How many Spasms, Infantile trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 6 |
| Active, not recruiting | 2 |
| Completed | 19 |
| Suspended | 1 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Spasms, Infantile trials? (8)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Lady Hardinge Medical College | 5 |
| Jazz Pharmaceuticals | 3 |
| Lundbeck LLC | 2 |
| Marinus Pharmaceuticals | 2 |
| Amzell | 1 |
Showing 5 of 8 sponsors.
Which drugs are being tested for Spasms, Infantile? (5)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Vigabatrin | 7 |
| Cannabidiol | 5 |
| PREDNISOLONE | 5 |
| Fenfluramine | 2 |
| Ganaxolone | 2 |
Interventions as named in the registry (10)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Acthar low dose (40 U) | 3 |
| Ketogenic diet | 2 |
| Topiramate IR | 1 |
| Famotidine FCT | 1 |
| Pyridoxine plus prednisolone | 1 |
Showing 5 of 10 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Spasms, Infantile trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Upper respiratory tract infection | 8 | 2 |
| Convulsion | 5 | 2 |
| Infantile spasms | 5 | 1 |
| Seizure | 5 | 2 |
| Dehydration | 4 | 2 |
Showing 5 of 10 adverse events.
Which publications cover Spasms, Infantile? (134)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Combination Therapy With Vigabatrin and Prednisolone Versus Vigabatrin Alone for Infantile Spasms. | Annals of clinical and translational neurology | 2025 | Yes |
| Modified Atkins diet versus topiramate in young children with epileptic spasms refractory to steroids and vigabatrin: a randomised open-label trial. | Seizure | 2025 | Yes |
| Gut microbiota profile in CDKL5 deficiency disorder patients. | Scientific reports | 2024 | Yes |
| Ganaxolone for management of seizures associated with CDKL5 deficiency disorder. | Trends in pharmacological sciences | 2023 | Yes |
| Comparison of evoked potentials across four related developmental encephalopathies. | Journal of neurodevelopmental disorders | 2023 | Yes |
Showing 5 of 134 publications.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| West syndrome | 3451 | Exact | Orphadata Science knowledge files, Product 1 |
| West syndrome | 3451 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and sub-conditions in mesh.