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Condition (MeSH)

Fibromyalgia

ClinicalTrials.gov lists 1,222 trials for Fibromyalgia or a narrower condition beneath it. Pfizer's Upjohn has merged with Mylan to form Viatris Inc. has the most among industry and government lead sponsors, with 19.

MeSH D005356 Musculoskeletal Diseases C05 C10 Listed by Orphanet as a rare disease
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Phase 1 Phase 1 27 Phase 1/2 Phase 1/2 13 Phase 2 Phase 2 80 Phase 2/3 Phase 2/3 16 Phase 3 Phase 3 81 Phase 4 Phase 4 50 Not applicable Not applicable 681 Observational Observational 273 Phase 1 Phase 1 27 Phase 1/2 Phase 1/2 13 Phase 2 Phase 2 80 Phase 2/3 Phase 2/3 16 Phase 3 Phase 3 81 Phase 4 Phase 4 50 Not applicable Not applicable 681 Observational Observational 273

Trials per phase (log scale)

1 more section with rows

1,222 of the 1,222 trials are tagged with Fibromyalgia itself; the rest are tagged with a narrower condition beneath it.

Get the Fibromyalgia report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Fibromyalgia trials start? (32)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 4 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 96

1994: 1 trials (Observational 1) 1995: 1 trials (Observational 1) 1996: 2 trials (Phase 2 2) 1998: 2 trials (Observational 1, Phase 2/3 1) 1999: 3 trials (Observational 1, Not applicable 1, Phase 2 1) 2000: 6 trials (Observational 1, Phase 4 1, Phase 3 1, Phase 1/2 1, Phase 1 2) 2001: 2 trials (Not applicable 2) 2002: 6 trials (Not applicable 3, Phase 4 1, Phase 3 1, Phase 2 1) 2003: 12 trials (Observational 1, Not applicable 7, Phase 2/3 1, Phase 1/2 1, Phase 1 2) 2004: 19 trials (Observational 1, Not applicable 5, Phase 4 1, Phase 3 5, Phase 2 5, Phase 1/2 2) 2005: 24 trials (Observational 3, Not applicable 5, Phase 3 7, Phase 2 7, Phase 1/2 1, Phase 1 1) 2006: 37 trials (Observational 2, Not applicable 10, Phase 4 2, Phase 3 13, Phase 2/3 3, Phase 2 6, Phase 1 1) 2007: 29 trials (Observational 3, Not applicable 11, Phase 4 3, Phase 3 8, Phase 2 3, Phase 1 1) 2008: 36 trials (Observational 9, Not applicable 7, Phase 4 9, Phase 3 3, Phase 2 7, Phase 1 1) 2009: 40 trials (Observational 5, Not applicable 19, Phase 4 4, Phase 3 5, Phase 2 2, Phase 1/2 1, Phase 1 4) 2010: 38 trials (Observational 8, Not applicable 15, Phase 4 10, Phase 3 2, Phase 2/3 2, Phase 2 1) 2011: 39 trials (Observational 12, Not applicable 11, Phase 4 4, Phase 3 5, Phase 2 7) 2012: 28 trials (Observational 3, Not applicable 9, Phase 4 2, Phase 3 10, Phase 2 2, Phase 1/2 1, Phase 1 1) 2013: 29 trials (Observational 3, Not applicable 17, Phase 3 2, Phase 2/3 2, Phase 2 3, Phase 1/2 1, Phase 1 1) 2014: 28 trials (Observational 4, Not applicable 18, Phase 3 2, Phase 2/3 1, Phase 2 1, Phase 1/2 1, Phase 1 1) 2015: 46 trials (Observational 6, Not applicable 31, Phase 4 1, Phase 3 5, Phase 2 2, Phase 1 1) 2016: 41 trials (Observational 7, Not applicable 29, Phase 4 2, Phase 3 3) 2017: 40 trials (Observational 6, Not applicable 29, Phase 4 2, Phase 2 3) 2018: 55 trials (Observational 20, Not applicable 28, Phase 4 1, Phase 2/3 2, Phase 2 2, Phase 1/2 1, Phase 1 1) 2019: 67 trials (Observational 8, Not applicable 53, Phase 3 1, Phase 2 3, Phase 1/2 1, Phase 1 1) 2020: 58 trials (Observational 11, Not applicable 38, Phase 4 1, Phase 3 2, Phase 2/3 1, Phase 2 3, Phase 1 2) 2021: 87 trials (Observational 26, Not applicable 49, Phase 4 1, Phase 3 2, Phase 2 6, Phase 1/2 1, Phase 1 2) 2022: 85 trials (Observational 27, Not applicable 51, Phase 3 2, Phase 2/3 1, Phase 2 3, Phase 1 1) 2023: 79 trials (Observational 28, Not applicable 44, Phase 4 3, Phase 2 2, Phase 1 2) 2024: 96 trials (Observational 26, Not applicable 66, Phase 4 1, Phase 2 3) 2025: 94 trials (Observational 31, Not applicable 59, Phase 2/3 1, Phase 2 1, Phase 1/2 1, Phase 1 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 85
2025 94
2024 96
2023 79
2022 85
2021 87
2020 58
2019 67
2018 55
2017 40

Forecast of the full-year count, planned starts included, not rows of this table: about 110 trials starting in 2026 and about 98 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 99 trials still running at the 2026-10-09 snapshot; registered median of 16 months across 767 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Fibromyalgia trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 27
Phase 1/2 13
Phase 2 80
Phase 2/3 16
Phase 3 81
Phase 4 50
Not applicable 681
Observational 273
Expanded access 1

How many Fibromyalgia trials are recruiting? (10)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 60
Recruiting 124
Enrolling by invitation 25
Active, not recruiting 26
Completed 744

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Fibromyalgia trials? (5)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. 19
Eli Lilly and Company 12
Tel-Aviv Sourasky Medical Center 10
VA Office of Research and Development 10
Forest Laboratories 9

Which drugs are being tested for Fibromyalgia? (5)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Pregabalin 41
Duloxetine 23
[S,S]-Reboxetine 6
Mirogabalin 6
Amitriptyline 5

Interventions as named in the registry (10)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Milnacipram 22
Exercise 19
Acupuncture 11
Treatment As Usual 7
Control (placebo) group 6

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Fibromyalgia trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Suicidal ideation 23 11
Pneumonia 13 12
Non-cardiac chest pain 10 5
Chest pain 9 7
Appendicitis 8 4

Which publications cover Fibromyalgia? (1,377)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

Browse all condition evidence pages