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Condition (MeSH)

Frostbite

ClinicalTrials.gov lists 16 trials for Frostbite or a narrower condition beneath it.

MeSH D005627 Wounds and Injuries C26
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Phase 4 Phase 4 3 Not applicable Not applicable 6 Observational Observational 7 Phase 4 Phase 4 3 Not applicable Not applicable 6 Observational Observational 7

Trials per phase

9 of the 16 trials are tagged with Frostbite itself; the rest are tagged with a narrower condition beneath it.

Get the Frostbite report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Frostbite trials start? (9)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 4
  • Not applicable
  • Observational

Top of scale: 5

2014: 1 trials (Not applicable 1) 2015: 1 trials (Observational 1) 2016: 1 trials (Observational 1) 2020: 5 trials (Observational 3, Not applicable 2) 2021: 1 trials (Not applicable 1) 2022: 2 trials (Not applicable 2) 2023: 1 trials (Observational 1) 2024: 1 trials (Phase 4 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 3
2024 1
2023 1
2022 2
2021 1
2020 5
2016 1
2015 1
2014 1

No forecast is made for this condition: it averages 1.2 trial starts a year over the five years to September, under the 5 a year the method needs.

Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Frostbite trials in? (3)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 4 3
Not applicable 6
Observational 7

How many Frostbite trials are recruiting? (4)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 3
Recruiting 2
Completed 10
Unknown status 1

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Frostbite trials? (2)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Bodychillz Ltd 1
Jinnah Postgraduate Medical Centre 1

Which drugs are being tested for Frostbite? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Dalbavancin 1
ILOPROST 1
Aloe Vera Gel 1

Interventions as named in the registry (5)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Biological sample collection 2
Standard of care plus Epoprostenol infusion for 8 hours (hrs) per day up to 5 days maximum 1
Hyperbaric oxygen treatment 1
Medicinal gas - oxygen (Nippon Gases 200 bar) 1
Indocyanine Green Angiogram 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which publications cover Frostbite? (48)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
American Burn Association Clinical Practice Guidelines on the Treatment of Severe Frostbite. Journal of burn care & research : official publication of the American Burn Association 2024 Yes
Systemic Prostacyclin Analogues for Frostbite Require Careful Monitoring. Journal of burn care & research : official publication of the American Burn Association 2023 Yes
Bleeding Complications in Patients With Severe Frostbite Injury. Journal of burn care & research : official publication of the American Burn Association 2023 Yes
Remote Delivery of Thrombolytics Prior to Transfer to a Regional Burn Center for Tissue Salvage in Frostbite: A Single-center Experience of 199 Patients. Journal of burn care & research : official publication of the American Burn Association 2022 Yes
The Effects of Rapid Rewarming on Tissue Salvage in Severe Frostbite Injury. Journal of burn care & research : official publication of the American Burn Association 2022 Yes

Sub-conditions in MeSH (1)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: serious adverse events in this condition's trials, prevalence, and rare-disease identity.

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