Condition (MeSH)
Heart Septal Defects
ClinicalTrials.gov lists 258 trials for Heart Septal Defects or a narrower condition beneath it. Abbott Medical Devices has the most among industry and government lead sponsors, with 14.
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Trials per phase (log scale)
1 more section with rows
12 of the 258 trials are tagged with Heart Septal Defects itself; the rest are tagged with a narrower condition beneath it.
When did Heart Septal Defects trials start? (31)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 21
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 19 |
| 2025 | 21 |
| 2024 | 16 |
| 2023 | 15 |
| 2022 | 19 |
| 2021 | 11 |
| 2020 | 15 |
| 2019 | 12 |
| 2018 | 13 |
| 2017 | 6 |
Showing 10 of 31 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 22 trials starting in 2026 and about 19 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 23 trials still running at the 2026-10-09 snapshot; registered median of 28 months across 116 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Heart Septal Defects trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 6 |
| Phase 1/2 | 2 |
| Phase 2 | 9 |
| Phase 2/3 | 2 |
| Phase 3 | 16 |
| Phase 4 | 12 |
| Not applicable | 102 |
| Observational | 107 |
| Expanded access | 2 |
How many Heart Septal Defects trials are recruiting? (11)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 19 |
| Recruiting | 48 |
| Enrolling by invitation | 3 |
| Active, not recruiting | 14 |
| Completed | 99 |
Showing 5 of 11 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Heart Septal Defects trials? (8)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Abbott Medical Devices | 14 |
| Lifetech Scientific (Shenzhen) Co., Ltd. | 12 |
| W.L.Gore & Associates | 7 |
| China National Center for Cardiovascular Diseases | 4 |
| National Heart, Lung, and Blood Institute (NHLBI) | 4 |
Showing 5 of 8 sponsors.
Which drugs are being tested for Heart Septal Defects? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| DEXMEDETOMIDINE | 4 |
| L-Citrulline | 2 |
| Fluorescite | 2 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| EC Aspirin | 5 |
| No Interventions | 2 |
| Clopidogrel 75 | 2 |
| Sham Procedure | 2 |
| BLOOD SAMPLES | 1 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Heart Septal Defects trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Elective Surgery | 50 | 3 |
| Ischemic Stroke | 47 | 2 |
| Chest Pain | 35 | 2 |
| Migraine | 25 | 4 |
| Pneumonia | 25 | 6 |
Showing 5 of 10 adverse events.
Which publications cover Heart Septal Defects? (26)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Pulmonary Atresia, Ventricular Septal Defect, and Major Aortopulmonary Collateral Arteries: The Natural History and Late Presentation. | World journal for pediatric & congenital heart surgery | 2025 | Yes |
| The American Association for Thoracic Surgery (AATS) 2022 Expert Consensus Document: Management of infants and neonates with tetralogy of Fallot. | The Journal of thoracic and cardiovascular surgery | 2023 | Yes |
| Loss of function in <i>ROBO1</i> is associated with tetralogy of Fallot and septal defects. | Journal of medical genetics | 2017 | Yes |
| Establishment of right ventricle-pulmonary artery continuity as the first-stage palliation in older infants with pulmonary atresia with ventricular septal defect may be preferable to use of an arterial shunt. | Interactive cardiovascular and thoracic surgery | 2014 | Yes |
| Genetic abnormalities in FOXP1 are associated with congenital heart defects. | Human mutation | 2013 | Yes |
Showing 5 of 26 publications.
Sub-conditions in MeSH (4)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.