Condition (MeSH)
Hyperemesis Gravidarum
ClinicalTrials.gov lists 40 trials for Hyperemesis Gravidarum or a narrower condition beneath it. Kayseri Education and Research Hospital has the most among industry and government lead sponsors, with 3.
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Trials per phase
40 of the 40 trials are tagged with Hyperemesis Gravidarum itself; the rest are tagged with a narrower condition beneath it.
When did Hyperemesis Gravidarum trials start? (18)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1/2
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 3 |
| 2025 | 4 |
| 2024 | 3 |
| 2023 | 2 |
| 2022 | 5 |
| 2021 | 1 |
| 2020 | 1 |
| 2019 | 3 |
| 2017 | 2 |
| 2016 | 4 |
Showing 10 of 18 earlier years.
No forecast is made for this condition: it averages 3.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 3 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Hyperemesis Gravidarum trials in? (6)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1/2 | 2 |
| Phase 2 | 3 |
| Phase 3 | 4 |
| Phase 4 | 2 |
| Not applicable | 14 |
| Observational | 15 |
How many Hyperemesis Gravidarum trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 2 |
| Recruiting | 3 |
| Active, not recruiting | 1 |
| Completed | 25 |
| Terminated | 2 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Hyperemesis Gravidarum trials? (5)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Kayseri Education and Research Hospital | 3 |
| Adana Numune Training and Research Hospital | 1 |
| Ankara Etlik City Hospital | 1 |
| Dr. Lutfi Kirdar Kartal Training and Research Hospital | 1 |
| Duchesnay Inc. | 1 |
Interventions as named in the registry (15)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Ondansetron - Parts A + B | 3 |
| Mirtazapine Pill | 2 |
| Doxylamine succinate 10 mg + Pyridoxine HCl 10 mg | 2 |
| Metclopramide | 2 |
| Capsaicin Topical Cream | 1 |
Showing 5 of 15 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Hyperemesis Gravidarum trials report? (6)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Abortion missed | 2 | 1 |
| Abortion spontaneous | 2 | 1 |
| Bile duct stone | 1 | 1 |
| Foetal disorder | 1 | 1 |
| Intra-uterine Death | 1 | 1 |
Showing 5 of 6 adverse events.
Which publications cover Hyperemesis Gravidarum? (62)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Prepregnancy metformin use associated with lower risk of severe nausea and vomiting of pregnancy and hyperemesis gravidarum. | American journal of obstetrics and gynecology | 2025 | Yes |
| Metformin for the Prevention of Hyperemesis Gravidarum: An Observational Cohort Study. | BJOG : an international journal of obstetrics and gynaecology | 2025 | Yes |
| GDF15 linked to maternal risk of nausea and vomiting during pregnancy. | Nature | 2024 | Yes |
| Effect of Acupressure at P6 on Nausea and Vomiting in Women with Hyperemesis Gravidarum: A Randomized Controlled Trial. | International journal of environmental research and public health | 2022 | Yes |
| Effect of gabapentin on hyperemesis gravidarum: a double-blind, randomized controlled trial. | American journal of obstetrics & gynecology MFM | 2021 | Yes |
Showing 5 of 62 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.