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Condition (MeSH)

Immunoproliferative Disorders

ClinicalTrials.gov lists 14,181 trials for Immunoproliferative Disorders or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 622.

MeSH D007160 Immune System Diseases C20
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Phase 1 Phase 1 3,202 Phase 1/2 Phase 1/2 1,620 Phase 2 Phase 2 4,387 Phase 2/3 Phase 2/3 151 Phase 3 Phase 3 1,142 Phase 4 Phase 4 269 Not applicable Not applicable 1,351 Observational Observational 1,985 Phase 1 Phase 1 3,202 Phase 1/2 Phase 1/2 1,620 Phase 2 Phase 2 4,387 Phase 2/3 Phase 2/3 151 Phase 3 Phase 3 1,142 Phase 4 Phase 4 269 Not applicable Not applicable 1,351 Observational Observational 1,985

Trials per phase (log scale)

2 more sections with rows

60 of the 14,181 trials are tagged with Immunoproliferative Disorders itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Immunoproliferative Disorders trials start? (37)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 38 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Expanded access, Unknown)

Top of scale: 756

1990: 11 trials (Not applicable 1, Phase 2/3 1, Phase 2 7, Phase 1 2) 1991: 8 trials (Observational 1, Not applicable 1, Phase 2 4, Phase 1 2) 1992: 14 trials (Observational 2, Phase 3 2, Phase 2 7, Phase 1/2 1, Phase 1 2) 1993: 22 trials (Observational 3, Not applicable 1, Phase 4 1, Phase 3 5, Phase 2 10, Phase 1 2) 1994: 28 trials (Observational 3, Phase 3 10, Phase 2 11, Phase 1 4) 1995: 53 trials (Observational 4, Not applicable 1, Phase 4 3, Phase 3 11, Phase 2/3 1, Phase 2 20, Phase 1/2 5, Phase 1 8) 1996: 66 trials (Observational 6, Not applicable 3, Phase 4 1, Phase 3 13, Phase 2 28, Phase 1/2 2, Phase 1 13) 1997: 88 trials (Observational 8, Not applicable 4, Phase 4 1, Phase 3 18, Phase 2/3 1, Phase 2 33, Phase 1/2 4, Phase 1 19) 1998: 132 trials (Observational 7, Not applicable 6, Phase 4 1, Phase 3 19, Phase 2/3 1, Phase 2 64, Phase 1/2 9, Phase 1 25) 1999: 161 trials (Observational 9, Not applicable 7, Phase 4 1, Phase 3 23, Phase 2/3 2, Phase 2 67, Phase 1/2 13, Phase 1 39) 2000: 200 trials (Observational 15, Not applicable 17, Phase 4 5, Phase 3 37, Phase 2/3 5, Phase 2 83, Phase 1/2 16, Phase 1 22) 2001: 178 trials (Observational 12, Not applicable 14, Phase 4 3, Phase 3 25, Phase 2/3 4, Phase 2 70, Phase 1/2 17, Phase 1 33) 2002: 216 trials (Observational 16, Not applicable 14, Phase 4 3, Phase 3 22, Phase 2/3 3, Phase 2 100, Phase 1/2 25, Phase 1 33) 2003: 252 trials (Observational 16, Not applicable 21, Phase 4 10, Phase 3 45, Phase 2/3 3, Phase 2 89, Phase 1/2 30, Phase 1 38) 2004: 327 trials (Observational 23, Not applicable 20, Phase 4 9, Phase 3 29, Phase 2/3 6, Phase 2 148, Phase 1/2 29, Phase 1 63) 2005: 359 trials (Observational 33, Not applicable 21, Phase 4 5, Phase 3 33, Phase 2/3 2, Phase 2 159, Phase 1/2 38, Phase 1 68) 2006: 404 trials (Observational 32, Not applicable 17, Phase 4 8, Phase 3 40, Phase 2/3 2, Phase 2 169, Phase 1/2 50, Phase 1 86) 2007: 421 trials (Other 1, Observational 32, Not applicable 24, Phase 4 5, Phase 3 35, Phase 2/3 2, Phase 2 165, Phase 1/2 42, Phase 1 115) 2008: 448 trials (Observational 62, Not applicable 29, Phase 4 5, Phase 3 34, Phase 2/3 6, Phase 2 159, Phase 1/2 53, Phase 1 100) 2009: 418 trials (Other 2, Observational 59, Not applicable 22, Phase 4 9, Phase 3 43, Phase 2/3 6, Phase 2 153, Phase 1/2 43, Phase 1 81) 2010: 474 trials (Observational 62, Not applicable 29, Phase 4 14, Phase 3 36, Phase 2/3 6, Phase 2 157, Phase 1/2 64, Phase 1 106) 2011: 449 trials (Observational 67, Not applicable 22, Phase 4 7, Phase 3 40, Phase 2/3 1, Phase 2 166, Phase 1/2 51, Phase 1 95) 2012: 467 trials (Observational 60, Not applicable 28, Phase 4 9, Phase 3 47, Phase 2 156, Phase 1/2 56, Phase 1 111) 2013: 424 trials (Observational 57, Not applicable 29, Phase 4 13, Phase 3 46, Phase 2/3 5, Phase 2 110, Phase 1/2 51, Phase 1 113) 2014: 445 trials (Observational 45, Not applicable 39, Phase 4 8, Phase 3 38, Phase 2/3 1, Phase 2 118, Phase 1/2 72, Phase 1 124) 2015: 488 trials (Observational 62, Not applicable 32, Phase 4 12, Phase 3 43, Phase 2/3 4, Phase 2 166, Phase 1/2 63, Phase 1 106) 2016: 573 trials (Observational 87, Not applicable 37, Phase 4 16, Phase 3 31, Phase 2/3 14, Phase 2 167, Phase 1/2 80, Phase 1 141) 2017: 602 trials (Observational 86, Not applicable 53, Phase 4 7, Phase 3 49, Phase 2/3 6, Phase 2 164, Phase 1/2 87, Phase 1 150) 2018: 604 trials (Observational 86, Not applicable 49, Phase 4 9, Phase 3 29, Phase 2/3 3, Phase 2 186, Phase 1/2 78, Phase 1 164) 2019: 633 trials (Observational 99, Not applicable 64, Phase 4 17, Phase 3 39, Phase 2/3 8, Phase 2 158, Phase 1/2 72, Phase 1 176) 2020: 634 trials (Observational 129, Not applicable 71, Phase 4 6, Phase 3 32, Phase 2/3 7, Phase 2 159, Phase 1/2 61, Phase 1 169) 2021: 752 trials (Observational 124, Not applicable 99, Phase 4 13, Phase 3 46, Phase 2/3 4, Phase 2 194, Phase 1/2 90, Phase 1 182) 2022: 756 trials (Observational 140, Not applicable 121, Phase 4 17, Phase 3 44, Phase 2/3 5, Phase 2 161, Phase 1/2 90, Phase 1 178) 2023: 747 trials (Observational 158, Not applicable 118, Phase 4 14, Phase 3 40, Phase 2/3 6, Phase 2 157, Phase 1/2 96, Phase 1 158) 2024: 746 trials (Observational 147, Not applicable 113, Phase 4 11, Phase 3 39, Phase 2/3 6, Phase 2 203, Phase 1/2 72, Phase 1 155) 2025: 719 trials (Observational 126, Not applicable 110, Phase 4 14, Phase 3 38, Phase 2/3 16, Phase 2 204, Phase 1/2 78, Phase 1 133)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 662
2025 719
2024 746
2023 747
2022 756
2021 752
2020 634
2019 633
2018 604
2017 602

Forecast of the full-year count, planned starts included, not rows of this table: about 820 trials starting in 2026 and about 740 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 10 percent and ran about 4 percent high against the count later registered; forecasts made before the year began were off by about 25 percent and ran about 15 percent low against the count later registered, and had about 7 percent more error than repeating last year's count. The part-way figures are from forecasts that used a multiple fitted only on earlier years. A stricter check that trains only on older years did not support adding planned starts for conditions of this size: it ran about 6 percent high against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 1,857 trials still running at the 2026-10-09 snapshot; registered median of 40 months across 8,353 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Immunoproliferative Disorders trials in? (10)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 3,202
Phase 1/2 1,620
Phase 2 4,387
Phase 2/3 151
Phase 3 1,142
Phase 4 269
Not applicable 1,351
Observational 1,985
Expanded access 73
Unknown 1

How many Immunoproliferative Disorders trials are recruiting? (13)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 555
Recruiting 2,031
Enrolling by invitation 61
Active, not recruiting 1,089
Available 17

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Immunoproliferative Disorders trials? (7)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Cancer Institute (NCI) 622
Celgene 159
Novartis Pharmaceuticals 141
Hoffmann-La Roche 138
Children's Oncology Group 113

Which drugs are being tested for Immunoproliferative Disorders? (4)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Cytoxan 1,364
RITUXIMAB 1,217
Prednisone 477
Melphalan 400

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Dexamethasone/Dexamethasone acetate 1,084
SQ Fludarabine 711
X: Lenalidomide 689
Vincristina 585
Bortezomib SC 564

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Immunoproliferative Disorders trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Pneumonia 9,393 899
Febrile neutropenia 7,179 859
Pyrexia 4,542 677
Sepsis 3,896 906
Neutrophil count decreased 3,719 332

Which publications cover Immunoproliferative Disorders? (1)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Morphologic features of extrahepatic manifestations of hepatitis C virus infection. Clinical & developmental immunology 2012 Yes

Sub-conditions in MeSH (3)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages