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Condition (MeSH)

Infertility

ClinicalTrials.gov lists 2,683 trials for Infertility or a narrower condition beneath it. Ferring Pharmaceuticals has the most among industry and government lead sponsors, with 47.

MeSH D007246 Urogenital Diseases C12
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Phase 1 Phase 1 89 Phase 1/2 Phase 1/2 37 Phase 2 Phase 2 121 Phase 2/3 Phase 2/3 57 Phase 3 Phase 3 206 Phase 4 Phase 4 307 Not applicable Not applicable 1,083 Observational Observational 781 Phase 1 Phase 1 89 Phase 1/2 Phase 1/2 37 Phase 2 Phase 2 121 Phase 2/3 Phase 2/3 57 Phase 3 Phase 3 206 Phase 4 Phase 4 307 Not applicable Not applicable 1,083 Observational Observational 781

Trials per phase (log scale)

1 more section with rows

1,985 of the 2,683 trials are tagged with Infertility itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Infertility trials start? (33)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 163

1991: 2 trials (Observational 1, Phase 1/2 1) 1992: 1 trials (Observational 1) 1996: 1 trials (Observational 1) 1997: 4 trials (Observational 2, Not applicable 1, Phase 3 1) 1998: 2 trials (Phase 2 2) 1999: 8 trials (Observational 3, Not applicable 2, Phase 3 1, Phase 2 2) 2000: 7 trials (Observational 3, Not applicable 1, Phase 3 1, Phase 2 1, Phase 1 1) 2001: 10 trials (Observational 2, Not applicable 3, Phase 3 2, Phase 2 3) 2002: 12 trials (Observational 6, Not applicable 1, Phase 3 2, Phase 2 3) 2003: 23 trials (Observational 5, Not applicable 3, Phase 4 10, Phase 3 4, Phase 2 1) 2004: 24 trials (Observational 6, Not applicable 7, Phase 4 4, Phase 3 7) 2005: 29 trials (Observational 6, Not applicable 7, Phase 4 7, Phase 3 4, Phase 2/3 1, Phase 2 3, Phase 1 1) 2006: 45 trials (Observational 22, Not applicable 11, Phase 4 7, Phase 3 4, Phase 2 1) 2007: 46 trials (Observational 9, Not applicable 16, Phase 4 8, Phase 3 4, Phase 2/3 1, Phase 2 6, Phase 1 2) 2008: 67 trials (Observational 15, Not applicable 23, Phase 4 14, Phase 3 5, Phase 2/3 1, Phase 2 3, Phase 1/2 4, Phase 1 2) 2009: 78 trials (Observational 21, Not applicable 19, Phase 4 18, Phase 3 8, Phase 2/3 4, Phase 2 5, Phase 1 3) 2010: 77 trials (Observational 23, Not applicable 20, Phase 4 12, Phase 3 7, Phase 2/3 1, Phase 2 3, Phase 1/2 6, Phase 1 5) 2011: 86 trials (Observational 23, Not applicable 29, Phase 4 16, Phase 3 6, Phase 2/3 2, Phase 2 4, Phase 1/2 2, Phase 1 4) 2012: 120 trials (Observational 38, Not applicable 37, Phase 4 18, Phase 3 10, Phase 2/3 3, Phase 2 8, Phase 1/2 1, Phase 1 5) 2013: 119 trials (Observational 25, Not applicable 47, Phase 4 17, Phase 3 15, Phase 2/3 5, Phase 2 6, Phase 1 4) 2014: 154 trials (Observational 42, Not applicable 55, Phase 4 21, Phase 3 15, Phase 2/3 10, Phase 2 6, Phase 1/2 1, Phase 1 4) 2015: 146 trials (Observational 31, Not applicable 59, Phase 4 15, Phase 3 23, Phase 2/3 1, Phase 2 10, Phase 1/2 1, Phase 1 6) 2016: 135 trials (Observational 32, Not applicable 60, Phase 4 23, Phase 3 10, Phase 2/3 3, Phase 2 4, Phase 1/2 3) 2017: 155 trials (Observational 37, Not applicable 65, Phase 4 22, Phase 3 11, Phase 2/3 4, Phase 2 9, Phase 1/2 2, Phase 1 5) 2018: 163 trials (Observational 37, Not applicable 91, Phase 4 10, Phase 3 12, Phase 2/3 3, Phase 2 4, Phase 1/2 1, Phase 1 5) 2019: 153 trials (Observational 39, Not applicable 77, Phase 4 20, Phase 3 7, Phase 2/3 4, Phase 2 4, Phase 1 2) 2020: 155 trials (Observational 46, Not applicable 73, Phase 4 16, Phase 3 6, Phase 2/3 1, Phase 2 7, Phase 1/2 2, Phase 1 4) 2021: 151 trials (Observational 62, Not applicable 55, Phase 4 12, Phase 3 7, Phase 2/3 4, Phase 2 4, Phase 1/2 2, Phase 1 5) 2022: 144 trials (Observational 54, Not applicable 59, Phase 4 8, Phase 3 8, Phase 2/3 4, Phase 2 7, Phase 1 4) 2023: 160 trials (Observational 58, Not applicable 76, Phase 4 5, Phase 3 8, Phase 2/3 1, Phase 2 3, Phase 1/2 1, Phase 1 8) 2024: 137 trials (Observational 48, Not applicable 64, Phase 4 7, Phase 3 4, Phase 2/3 1, Phase 2 1, Phase 1/2 4, Phase 1 8) 2025: 121 trials (Observational 35, Not applicable 54, Phase 4 9, Phase 3 6, Phase 2/3 2, Phase 2 3, Phase 1/2 3, Phase 1 9)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 132
2025 121
2024 137
2023 160
2022 144
2021 151
2020 155
2019 153
2018 163
2017 155

Showing 10 of 33 earlier years.

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Forecast of the full-year count, planned starts included, not rows of this table: about 150 trials starting in 2026 and about 130 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 35 months from start to primary completion across 196 trials still running at the 2026-10-09 snapshot; registered median of 21 months across 1,518 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Infertility trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 89
Phase 1/2 37
Phase 2 121
Phase 2/3 57
Phase 3 206
Phase 4 307
Not applicable 1,083
Observational 781
Expanded access 2

How many Infertility trials are recruiting? (11)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 114
Recruiting 258
Enrolling by invitation 18
Active, not recruiting 62
Available 1

Showing 5 of 11 statuses.

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Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Infertility trials? (4)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Ferring Pharmaceuticals 47
Merck KGaA, Darmstadt, Germany 35
Royan Institute 27
Clinique Ovo 24

Which drugs are being tested for Infertility? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Cetrorelix 24
Follitropin Delta 18
Menotropin 16

Interventions as named in the registry (12)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
r-hCG 67
clomiphen citrate 48
US Gonal-f® 45
Progesterone 8% 42
Letrozol (Femara, Novartis) 39

Showing 5 of 12 interventions.

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These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Infertility trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Ovarian hyperstimulation syndrome 147 26
Ectopic pregnancy 104 29
PREMATURE BABY 32 1
Abortion spontaneous 31 13
ARRESTED LABOUR 29 1

Showing 5 of 10 adverse events.

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Which publications cover Infertility? (639)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Ovarian stimulation with follitropin delta is safe and effective: results from the RITA randomized, double-blind, placebo-controlled trials. Fertility and sterility 2026 Yes
Swim-up versus density gradients for sperm preparation in infertile couples undergoing intrauterine insemination: a randomized clinical trial. Human reproduction (Oxford, England) 2025 Yes
Target trial emulation of preconception serum vitamin D status on fertility outcomes: a couples-based approach. Fertility and sterility 2025 Yes
Intracytoplasmic sperm injection versus conventional in vitro fertilization in infertile couples with normal total sperm count and motility: does sperm morphology matter? Human reproduction (Oxford, England) 2025 Yes
The perception of artificial intelligence and infertility care among patients undergoing fertility treatment. Journal of assisted reproduction and genetics 2025 Yes

Showing 5 of 639 publications.

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Sub-conditions in MeSH (2)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

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