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Condition (MeSH)

Genital Diseases

ClinicalTrials.gov lists 28,924 trials for Genital Diseases or a narrower condition beneath it. National Institute of Allergy and Infectious Diseases (NIAID) has the most among industry and government lead sponsors, with 1,091.

MeSH D000091662 Urogenital Diseases C12
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Phase 1 Phase 1 3,347 Phase 1/2 Phase 1/2 1,217 Phase 2 Phase 2 4,574 Phase 2/3 Phase 2/3 370 Phase 3 Phase 3 2,538 Phase 4 Phase 4 1,709 Not applicable Not applicable 8,833 Observational Observational 6,281 Phase 1 Phase 1 3,347 Phase 1/2 Phase 1/2 1,217 Phase 2 Phase 2 4,574 Phase 2/3 Phase 2/3 370 Phase 3 Phase 3 2,538 Phase 4 Phase 4 1,709 Not applicable Not applicable 8,833 Observational Observational 6,281

Trials per phase (log scale)

2 more sections with rows

13 of the 28,924 trials are tagged with Genital Diseases itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Genital Diseases trials start? (37)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 62 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Expanded access, Unknown)

Top of scale: 1,516

1990: 11 trials (Observational 3, Not applicable 1, Phase 3 3, Phase 2 3, Phase 1/2 1) 1991: 14 trials (Observational 2, Phase 3 2, Phase 2 5, Phase 1/2 1, Phase 1 4) 1992: 20 trials (Observational 9, Not applicable 1, Phase 3 6, Phase 2 2, Phase 1 2) 1993: 16 trials (Observational 6, Not applicable 2, Phase 3 2, Phase 2 6) 1994: 35 trials (Observational 10, Not applicable 3, Phase 4 2, Phase 3 7, Phase 2/3 1, Phase 2 1, Phase 1/2 3, Phase 1 8) 1995: 45 trials (Observational 10, Not applicable 2, Phase 3 12, Phase 2/3 1, Phase 2 11, Phase 1/2 2, Phase 1 7) 1996: 59 trials (Observational 12, Not applicable 2, Phase 4 1, Phase 3 17, Phase 2/3 1, Phase 2 16, Phase 1/2 1, Phase 1 9) 1997: 100 trials (Observational 14, Not applicable 13, Phase 3 21, Phase 2 27, Phase 1/2 8, Phase 1 17) 1998: 130 trials (Observational 17, Not applicable 9, Phase 4 5, Phase 3 24, Phase 2/3 1, Phase 2 48, Phase 1/2 3, Phase 1 23) 1999: 214 trials (Observational 32, Not applicable 18, Phase 4 7, Phase 3 45, Phase 2/3 3, Phase 2 66, Phase 1/2 9, Phase 1 34) 2000: 233 trials (Other 1, Observational 43, Not applicable 21, Phase 4 5, Phase 3 41, Phase 2/3 1, Phase 2 73, Phase 1/2 10, Phase 1 38) 2001: 271 trials (Other 1, Observational 36, Not applicable 33, Phase 4 10, Phase 3 48, Phase 2/3 7, Phase 2 96, Phase 1/2 17, Phase 1 23) 2002: 372 trials (Other 1, Observational 73, Not applicable 49, Phase 4 27, Phase 3 62, Phase 2/3 8, Phase 2 110, Phase 1/2 16, Phase 1 26) 2003: 519 trials (Other 1, Observational 87, Not applicable 66, Phase 4 70, Phase 3 94, Phase 2/3 5, Phase 2 127, Phase 1/2 27, Phase 1 42) 2004: 585 trials (Other 2, Observational 104, Not applicable 70, Phase 4 71, Phase 3 96, Phase 2/3 9, Phase 2 153, Phase 1/2 25, Phase 1 55) 2005: 700 trials (Observational 125, Not applicable 107, Phase 4 85, Phase 3 89, Phase 2/3 11, Phase 2 172, Phase 1/2 35, Phase 1 76) 2006: 775 trials (Observational 138, Not applicable 134, Phase 4 71, Phase 3 96, Phase 2/3 18, Phase 2 187, Phase 1/2 39, Phase 1 92) 2007: 824 trials (Observational 156, Not applicable 142, Phase 4 65, Phase 3 110, Phase 2/3 12, Phase 2 196, Phase 1/2 29, Phase 1 114) 2008: 843 trials (Observational 168, Not applicable 171, Phase 4 92, Phase 3 95, Phase 2/3 8, Phase 2 170, Phase 1/2 36, Phase 1 103) 2009: 945 trials (Observational 211, Not applicable 180, Phase 4 90, Phase 3 119, Phase 2/3 17, Phase 2 175, Phase 1/2 42, Phase 1 111) 2010: 872 trials (Other 1, Observational 201, Not applicable 173, Phase 4 75, Phase 3 88, Phase 2/3 12, Phase 2 145, Phase 1/2 51, Phase 1 126) 2011: 896 trials (Observational 190, Not applicable 223, Phase 4 70, Phase 3 105, Phase 2/3 11, Phase 2 136, Phase 1/2 29, Phase 1 132) 2012: 912 trials (Other 1, Observational 209, Not applicable 274, Phase 4 67, Phase 3 87, Phase 2/3 13, Phase 2 134, Phase 1/2 40, Phase 1 87) 2013: 909 trials (Observational 206, Not applicable 279, Phase 4 71, Phase 3 74, Phase 2/3 14, Phase 2 138, Phase 1/2 32, Phase 1 95) 2014: 1,004 trials (Observational 212, Not applicable 322, Phase 4 68, Phase 3 84, Phase 2/3 19, Phase 2 131, Phase 1/2 45, Phase 1 123) 2015: 1,107 trials (Observational 233, Not applicable 378, Phase 4 60, Phase 3 89, Phase 2/3 8, Phase 2 150, Phase 1/2 39, Phase 1 150) 2016: 1,144 trials (Other 1, Observational 249, Not applicable 395, Phase 4 72, Phase 3 80, Phase 2/3 22, Phase 2 145, Phase 1/2 56, Phase 1 124) 2017: 1,261 trials (Observational 280, Not applicable 467, Phase 4 72, Phase 3 69, Phase 2/3 17, Phase 2 160, Phase 1/2 50, Phase 1 146) 2018: 1,267 trials (Observational 256, Not applicable 503, Phase 4 62, Phase 3 83, Phase 2/3 19, Phase 2 174, Phase 1/2 49, Phase 1 121) 2019: 1,376 trials (Observational 324, Not applicable 497, Phase 4 72, Phase 3 86, Phase 2/3 18, Phase 2 166, Phase 1/2 58, Phase 1 155) 2020: 1,302 trials (Observational 346, Not applicable 453, Phase 4 67, Phase 3 92, Phase 2/3 14, Phase 2 146, Phase 1/2 53, Phase 1 131) 2021: 1,491 trials (Observational 382, Not applicable 543, Phase 4 71, Phase 3 91, Phase 2/3 16, Phase 2 181, Phase 1/2 63, Phase 1 144) 2022: 1,436 trials (Observational 387, Not applicable 562, Phase 4 44, Phase 3 72, Phase 2/3 18, Phase 2 153, Phase 1/2 52, Phase 1 148) 2023: 1,510 trials (Other 1, Observational 399, Not applicable 611, Phase 4 57, Phase 3 73, Phase 2/3 18, Phase 2 155, Phase 1/2 64, Phase 1 132) 2024: 1,516 trials (Observational 400, Not applicable 590, Phase 4 46, Phase 3 69, Phase 2/3 19, Phase 2 181, Phase 1/2 66, Phase 1 145) 2025: 1,443 trials (Observational 336, Not applicable 599, Phase 4 52, Phase 3 83, Phase 2/3 15, Phase 2 161, Phase 1/2 74, Phase 1 123)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 1,404
2025 1,443
2024 1,516
2023 1,510
2022 1,436
2021 1,491
2020 1,302
2019 1,376
2018 1,267
2017 1,261

Forecast of the full-year count, planned starts included, not rows of this table: about 1,700 trials starting in 2026 and about 1,500 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 10 percent and ran about 4 percent high against the count later registered; forecasts made before the year began were off by about 25 percent and ran about 15 percent low against the count later registered, and had about 7 percent more error than repeating last year's count. The part-way figures are from forecasts that used a multiple fitted only on earlier years. A stricter check that trains only on older years did not support adding planned starts for conditions of this size: it ran about 6 percent high against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 2,725 trials still running at the 2026-10-09 snapshot; registered median of 27 months across 16,685 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Genital Diseases trials in? (10)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 3,347
Phase 1/2 1,217
Phase 2 4,574
Phase 2/3 370
Phase 3 2,538
Phase 4 1,709
Not applicable 8,833
Observational 6,281
Expanded access 52
Unknown 3

How many Genital Diseases trials are recruiting? (13)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 1,184
Recruiting 3,246
Enrolling by invitation 163
Active, not recruiting 1,359
Available 12

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Genital Diseases trials? (8)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Institute of Allergy and Infectious Diseases (NIAID) 1,091
National Cancer Institute (NCI) 548
ViiV Healthcare 248
GlaxoSmithKline 240
Merck Sharp & Dohme LLC 202

Which drugs are being tested for Genital Diseases? (8)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
(nab)-paclitaxel 499
Zidovudine 277
PEMBROLIZUMAB 232
Prednisone 226
Abiraterone 214

Interventions as named in the registry (7)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
or carboplatin 463
Docetetaxel 337
Cisplatin 1 301
Bevacizumab 1 246
1% Metformin 216

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Genital Diseases trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Pneumonia 3,620 624
Anaemia 2,692 441
Vomiting 2,408 614
Neutropenia 1,995 266
Urinary tract infection 1,982 454

Which publications cover Genital Diseases? (1)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Neutralizing Antibody Kinetics and Immune Protection Against Herpes Simplex Virus 1 Genital Disease in Vaccinated Women. The Journal of infectious diseases 2023 Yes

Sub-conditions in MeSH (5)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages