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Condition (MeSH)

Labyrinth Diseases

ClinicalTrials.gov lists 435 trials for Labyrinth Diseases or a narrower condition beneath it. Otonomy, Inc. has the most among industry and government lead sponsors, with 9.

MeSH D007759 Otorhinolaryngologic Diseases C09
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Phase 1 Phase 1 12 Phase 1/2 Phase 1/2 6 Phase 2 Phase 2 21 Phase 2/3 Phase 2/3 3 Phase 3 Phase 3 21 Phase 4 Phase 4 21 Not applicable Not applicable 248 Observational Observational 103 Phase 1 Phase 1 12 Phase 1/2 Phase 1/2 6 Phase 2 Phase 2 21 Phase 2/3 Phase 2/3 3 Phase 3 Phase 3 21 Phase 4 Phase 4 21 Not applicable Not applicable 248 Observational Observational 103

Trials per phase (log scale)

22 of the 435 trials are tagged with Labyrinth Diseases itself; the rest are tagged with a narrower condition beneath it.

Get the Labyrinth Diseases report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Labyrinth Diseases trials start? (27)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 46

1995: 1 trials (Not applicable 1) 1996: 1 trials (Not applicable 1) 1998: 3 trials (Not applicable 1, Phase 3 1, Phase 2 1) 2002: 3 trials (Observational 1, Phase 4 1, Phase 3 1) 2003: 1 trials (Phase 4 1) 2005: 6 trials (Observational 1, Not applicable 2, Phase 4 1, Phase 2 1, Phase 1 1) 2006: 2 trials (Not applicable 1, Phase 1/2 1) 2007: 4 trials (Observational 1, Not applicable 2, Phase 4 1) 2008: 4 trials (Not applicable 3, Phase 4 1) 2009: 9 trials (Observational 2, Not applicable 4, Phase 3 2, Phase 2/3 1) 2010: 4 trials (Observational 1, Not applicable 1, Phase 4 1, Phase 1 1) 2011: 10 trials (Observational 1, Not applicable 5, Phase 3 2, Phase 2/3 1, Phase 1/2 1) 2012: 9 trials (Not applicable 5, Phase 4 2, Phase 3 1, Phase 1 1) 2013: 17 trials (Observational 1, Not applicable 7, Phase 4 3, Phase 3 1, Phase 2 5) 2014: 13 trials (Observational 3, Not applicable 5, Phase 4 1, Phase 3 1, Phase 2 3) 2015: 14 trials (Observational 3, Not applicable 8, Phase 4 1, Phase 3 1, Phase 1/2 1) 2016: 27 trials (Observational 3, Not applicable 14, Phase 4 3, Phase 3 4, Phase 2 1, Phase 1 2) 2017: 14 trials (Observational 5, Not applicable 6, Phase 2 3) 2018: 27 trials (Observational 9, Not applicable 16, Phase 3 1, Phase 1 1) 2019: 39 trials (Observational 13, Not applicable 23, Phase 2 3) 2020: 27 trials (Observational 5, Not applicable 19, Phase 2/3 1, Phase 2 2) 2021: 46 trials (Observational 14, Not applicable 26, Phase 4 2, Phase 2 1, Phase 1/2 1, Phase 1 2) 2022: 36 trials (Observational 5, Not applicable 26, Phase 4 1, Phase 3 3, Phase 1/2 1) 2023: 39 trials (Observational 11, Not applicable 23, Phase 3 1, Phase 2 1, Phase 1/2 1, Phase 1 2) 2024: 34 trials (Observational 8, Not applicable 22, Phase 4 2, Phase 3 1, Phase 1 1) 2025: 23 trials (Observational 10, Not applicable 11, Phase 3 1, Phase 1 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 22
2025 23
2024 34
2023 39
2022 36
2021 46
2020 27
2019 39
2018 27
2017 14

Forecast of the full-year count, planned starts included, not rows of this table: about 28 trials starting in 2026 and about 26 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 32 trials still running at the 2026-10-09 snapshot; registered median of 17 months across 252 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Labyrinth Diseases trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 12
Phase 1/2 6
Phase 2 21
Phase 2/3 3
Phase 3 21
Phase 4 21
Not applicable 248
Observational 103

How many Labyrinth Diseases trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 25
Recruiting 45
Enrolling by invitation 4
Active, not recruiting 13
Completed 227

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Labyrinth Diseases trials? (3)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Otonomy, Inc. 9
Region Stockholm 5
Sound Pharmaceuticals, Incorporated 5

Which drugs are being tested for Labyrinth Diseases? (6)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Betahistine 9
Ebselen 4
Dimenhydrinate 4
Calcium/Vitamin D 3
METHYLPREDNISOLONE 3

Interventions as named in the registry (9)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Dexamethasone/Dexamethasone acetate 10
Control (placebo) group 5
Diphenhydramine 5% 3
Acupuncture 2
citrate of caffeine 2

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Labyrinth Diseases trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Inpatient hospitalization 7 1
Infective pulmonary exacerbation of cystic fibrosis 3 1
Unsuccessful Initial Activation 2 1
Abdominal Pain and Constipation 1 1
Acute Myeloid Leukemia 1 1

Which publications cover Labyrinth Diseases? (24)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Clinical features of otolith organ-specific vestibular dysfunction. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2018 Yes
Loss of MAFB Function in Humans and Mice Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects. American journal of human genetics 2016 Yes
Restudy of malformations of the internal auditory meatus, cochlear nerve canal and cochlear nerve. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2015 Yes
Pathophysiology of inner ear decompression sickness: potential role of the persistent foramen ovale. Diving and hyperbaric medicine 2015 Yes
Inner-ear decompression sickness: 'hubble-bubble' without brain trouble? Diving and hyperbaric medicine 2015 Yes

Sub-conditions in MeSH (5)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages