Condition (MeSH)
Ear Diseases
ClinicalTrials.gov lists 2,738 trials for Ear Diseases or a narrower condition beneath it. Cochlear has the most among industry and government lead sponsors, with 84.
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Trials per phase (log scale)
2 more sections with rows
45 of the 2,738 trials are tagged with Ear Diseases itself; the rest are tagged with a narrower condition beneath it.
When did Ear Diseases trials start? (34)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 15 trials are registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
- Other (Unknown)
Top of scale: 220
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 182 |
| 2025 | 189 |
| 2024 | 197 |
| 2023 | 185 |
| 2022 | 202 |
| 2021 | 220 |
| 2020 | 149 |
| 2019 | 177 |
| 2018 | 166 |
| 2017 | 128 |
Showing 10 of 34 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 210 trials starting in 2026 and about 200 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 253 trials still running at the 2026-10-09 snapshot; registered median of 17 months across 1,597 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Ear Diseases trials in? (10)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 87 |
| Phase 1/2 | 57 |
| Phase 2 | 163 |
| Phase 2/3 | 29 |
| Phase 3 | 125 |
| Phase 4 | 88 |
| Not applicable | 1,514 |
| Observational | 664 |
| Expanded access | 3 |
| Unknown | 8 |
How many Ear Diseases trials are recruiting? (11)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 180 |
| Recruiting | 324 |
| Enrolling by invitation | 32 |
| Active, not recruiting | 73 |
| Available | 1 |
Showing 5 of 11 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Ear Diseases trials? (6)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Cochlear | 84 |
| Sonova AG | 81 |
| Oticon Medical | 43 |
| VA Office of Research and Development | 28 |
| MED-EL Elektromedizinische Geräte GesmbH | 24 |
Showing 5 of 6 sponsors.
Which drugs are being tested for Ear Diseases? (6)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Betahistine | 10 |
| METHYLPREDNISOLONE | 10 |
| Ebselen | 7 |
| Prednisone | 7 |
| Clotrimazole | 6 |
Showing 5 of 6 drugs.
Interventions as named in the registry (9)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Dexamethasone/Dexamethasone acetate | 22 |
| N Acetylcysteine | 12 |
| Acupuncture | 11 |
| Control (placebo) group | 8 |
| Amoxicillin and clavulanate | 7 |
Showing 5 of 9 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Ear Diseases trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Gastroenteritis | 1,096 | 8 |
| Pneumonia | 1,090 | 12 |
| Bronchiolitis | 1,031 | 6 |
| Dehydration | 915 | 9 |
| Asthmatic crisis | 402 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Ear Diseases? (69)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Balloon dilatation of the Eustachian tube for obstructive Eustachian tube dysfunction in adults. | The Cochrane database of systematic reviews | 2025 | Yes |
| The Usefulness of ETDQ-7 Score in Assessing ETD. | Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery | 2025 | Yes |
| Balloon dilation for persistent unilateral chronic obstructive Eustachian tube dysfunction is effective: a prospective multicentre study. | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery | 2023 | Yes |
| Are the hearing and eustachian tube functions of the hot air balloon pilots disturbed? | Auris, nasus, larynx | 2022 | Yes |
| Can the negative pressures found in obstructive sleep apnea and Eustachian tube dysfunction be related? | American journal of otolaryngology | 2021 | Yes |
Showing 5 of 69 publications.
Sub-conditions in MeSH (16)
MeSH descendants one level down with at least one trial, most trials first.
+6 more sub-conditions
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.