Condition (MeSH)
Tympanic Membrane Perforation
ClinicalTrials.gov lists 48 trials for Tympanic Membrane Perforation or a narrower condition beneath it. Grace Medical, Inc. has the most among industry and government lead sponsors, with 2.
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Trials per phase (log scale)
1 more section with rows
48 of the 48 trials are tagged with Tympanic Membrane Perforation itself; the rest are tagged with a narrower condition beneath it.
When did Tympanic Membrane Perforation trials start? (17)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
- Other (Unknown)
Top of scale: 6
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 4 |
| 2025 | 2 |
| 2024 | 6 |
| 2023 | 2 |
| 2022 | 3 |
| 2021 | 6 |
| 2020 | 2 |
| 2018 | 4 |
| 2017 | 3 |
| 2016 | 3 |
Showing 10 of 17 earlier years.
No forecast is made for this condition: it averages 3.0 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 3 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Tympanic Membrane Perforation trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 2 |
| Phase 1/2 | 1 |
| Phase 2 | 2 |
| Phase 2/3 | 2 |
| Phase 3 | 4 |
| Phase 4 | 2 |
| Not applicable | 23 |
| Observational | 11 |
| Unknown | 1 |
How many Tympanic Membrane Perforation trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 7 |
| Recruiting | 4 |
| Completed | 21 |
| Terminated | 2 |
| Withdrawn | 5 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Tympanic Membrane Perforation trials? (4)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Grace Medical, Inc. | 2 |
| CLOTILDE FUENTES OROZCO | 1 |
| Central Adelaide Local Health Network Incorporated | 1 |
| Cook Research Incorporated | 1 |
Interventions as named in the registry (15)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| FGF 2 | 2 |
| local anaesthetic injection | 1 |
| Platelet- and extracellular vesicle-rich plasma | 1 |
| General anesthetic | 1 |
| fiblast,gelatin sponge,fibrin glue | 1 |
Showing 5 of 15 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which publications cover Tympanic Membrane Perforation? (37)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Surgical results and factors affecting outcome in patients with fat-graft myringoplasty. | Ear, nose, & throat journal | 2024 | Yes |
| Ventilation tubes (grommets) for otitis media with effusion (OME) in children. | The Cochrane database of systematic reviews | 2023 | Yes |
| Prevalence of Tympanic Membrane Perforations Among Adolescents, Adults, and Older Adults in the United States. | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery | 2022 | Yes |
| Endoscopic single versus double flap tympanoplasty: a randomized clinical trial. | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery | 2021 | Yes |
| Long-term outcomes of cartilage tympanoplasty in 139 ears in children. | Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery | 2021 | Yes |
Showing 5 of 37 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: serious adverse events in this condition's trials, prevalence, rare-disease identity, and sub-conditions in mesh.