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Condition (MeSH)

Language Disorders

ClinicalTrials.gov lists 880 trials for Language Disorders or a narrower condition beneath it. VA Office of Research and Development has the most among industry and government lead sponsors, with 18.

MeSH D007806 Nervous System Diseases C10 C23
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Phase 1 Phase 1 21 Phase 1/2 Phase 1/2 9 Phase 2 Phase 2 43 Phase 2/3 Phase 2/3 7 Phase 3 Phase 3 14 Phase 4 Phase 4 13 Not applicable Not applicable 634 Observational Observational 139 Phase 1 Phase 1 21 Phase 1/2 Phase 1/2 9 Phase 2 Phase 2 43 Phase 2/3 Phase 2/3 7 Phase 3 Phase 3 14 Phase 4 Phase 4 13 Not applicable Not applicable 634 Observational Observational 139

Trials per phase (log scale)

81 of the 880 trials are tagged with Language Disorders itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Language Disorders trials start? (33)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 4 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 92

1992: 1 trials (Observational 1) 1993: 1 trials (Phase 3 1) 1995: 2 trials (Observational 1, Not applicable 1) 1996: 2 trials (Observational 2) 1998: 1 trials (Phase 4 1) 1999: 3 trials (Observational 3) 2000: 4 trials (Observational 3, Not applicable 1) 2001: 3 trials (Observational 2, Phase 3 1) 2002: 6 trials (Not applicable 3, Phase 3 1, Phase 1 2) 2003: 5 trials (Observational 2, Not applicable 1, Phase 4 1, Phase 3 1) 2004: 7 trials (Observational 2, Not applicable 4, Phase 1 1) 2005: 12 trials (Not applicable 6, Phase 4 5, Phase 1 1) 2006: 4 trials (Observational 1, Not applicable 2, Phase 1 1) 2007: 11 trials (Observational 2, Not applicable 6, Phase 2/3 1, Phase 1/2 2) 2008: 9 trials (Not applicable 3, Phase 4 2, Phase 3 1, Phase 2/3 1, Phase 2 2) 2009: 20 trials (Observational 3, Not applicable 10, Phase 2/3 2, Phase 2 4, Phase 1/2 1) 2010: 11 trials (Observational 1, Not applicable 5, Phase 4 1, Phase 3 1, Phase 1 3) 2011: 14 trials (Observational 3, Not applicable 6, Phase 2 3, Phase 1/2 1, Phase 1 1) 2012: 21 trials (Observational 4, Not applicable 13, Phase 3 1, Phase 2 1, Phase 1 2) 2013: 23 trials (Observational 3, Not applicable 20) 2014: 37 trials (Observational 9, Not applicable 22, Phase 3 1, Phase 2 3, Phase 1/2 2) 2015: 21 trials (Observational 2, Not applicable 16, Phase 3 2, Phase 2 1) 2016: 34 trials (Observational 3, Not applicable 27, Phase 3 1, Phase 2/3 1, Phase 2 1, Phase 1 1) 2017: 40 trials (Observational 7, Not applicable 32, Phase 1 1) 2018: 66 trials (Observational 11, Not applicable 52, Phase 4 1, Phase 2 1, Phase 1 1) 2019: 38 trials (Observational 8, Not applicable 25, Phase 3 1, Phase 2 3, Phase 1 1) 2020: 65 trials (Observational 9, Not applicable 45, Phase 2 7, Phase 1/2 1, Phase 1 3) 2021: 71 trials (Observational 10, Not applicable 59, Phase 2 2) 2022: 61 trials (Observational 11, Not applicable 48, Phase 4 1, Phase 2 1) 2023: 92 trials (Observational 11, Not applicable 74, Phase 4 1, Phase 3 1, Phase 2 4, Phase 1/2 1) 2024: 54 trials (Observational 4, Not applicable 45, Phase 2/3 1, Phase 2 3, Phase 1 1) 2025: 82 trials (Observational 15, Not applicable 60, Phase 2 4, Phase 1/2 1, Phase 1 2)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 53
2025 82
2024 54
2023 92
2022 61
2021 71
2020 65
2019 38
2018 66
2017 40

Showing 10 of 33 earlier years.

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Forecast of the full-year count, planned starts included, not rows of this table: about 70 trials starting in 2026 and about 71 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 143 trials still running at the 2026-10-09 snapshot; registered median of 26 months across 482 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Language Disorders trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 21
Phase 1/2 9
Phase 2 43
Phase 2/3 7
Phase 3 14
Phase 4 13
Not applicable 634
Observational 139

How many Language Disorders trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 35
Recruiting 178
Enrolling by invitation 17
Active, not recruiting 32
Completed 449

Showing 5 of 9 statuses.

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Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Language Disorders trials? (1)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
VA Office of Research and Development 18

Which drugs are being tested for Language Disorders? (1)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Ecopipam 2

Interventions as named in the registry (14)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Transcranial Magnetic Stimulation 12
tDCS 8
Treatment As Usual 7
Control (placebo) group 4
Atomoxetine arm 4

Showing 5 of 14 interventions.

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These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Language Disorders trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Medical event 10 1
Death 8 1
Intracranial hemorrhage 6 1
Outpatient Surgery (e.g., Tonsillectomy, adenoidectomy, frenectomy, tympanostomy) 6 1
Cerebrovascular accident 3 2

Showing 5 of 10 adverse events.

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Which publications cover Language Disorders? (193)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Characterization of Speech and Language Deficits in the Postanesthesia Care Unit: A Novel, Qualitative Cognitive Assessment. Anesthesia and analgesia 2025 Yes
Advanced Brain Age and Chronic Poststroke Aphasia Severity. Neurology 2023 Yes
A randomized study of parent- versus child-directed intervention for Dutch toddlers with DLD. International journal of language & communication disorders 2023 Yes
It is time to address language disorders in schizophrenia: A RCT on the efficacy of a novel training targeting the pragmatics of communication (PragmaCom). Journal of communication disorders 2022 Yes
Can Dynamic Assessment Identify Language Disorder in Multilingual Children? Clinical Applications From a Systematic Review. Language, speech, and hearing services in schools 2022 Yes

Showing 5 of 193 publications.

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Sub-conditions in MeSH (5)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

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