Condition (MeSH)
Leg Injuries
ClinicalTrials.gov lists 2,746 trials for Leg Injuries or a narrower condition beneath it. Zimmer Biomet has the most among industry and government lead sponsors, with 26.
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Trials per phase (log scale)
1 more section with rows
65 of the 2,746 trials are tagged with Leg Injuries itself; the rest are tagged with a narrower condition beneath it.
When did Leg Injuries trials start? (34)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 7 trials are registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
- Other (Unknown)
Top of scale: 239
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 146 |
| 2025 | 193 |
| 2024 | 239 |
| 2023 | 199 |
| 2022 | 239 |
| 2021 | 225 |
| 2020 | 171 |
| 2019 | 152 |
| 2018 | 155 |
| 2017 | 122 |
Showing 10 of 34 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 180 trials starting in 2026 and about 190 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 262 trials still running at the 2026-10-09 snapshot; registered median of 20 months across 1,550 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Leg Injuries trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 36 |
| Phase 1/2 | 15 |
| Phase 2 | 64 |
| Phase 2/3 | 19 |
| Phase 3 | 92 |
| Phase 4 | 170 |
| Not applicable | 1,586 |
| Observational | 763 |
| Unknown | 1 |
How many Leg Injuries trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 126 |
| Recruiting | 329 |
| Enrolling by invitation | 33 |
| Active, not recruiting | 111 |
| Completed | 1,337 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Leg Injuries trials? (1)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Zimmer Biomet | 26 |
Which drugs are being tested for Leg Injuries? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| +/- Bupivacaine HCl | 39 |
Interventions as named in the registry (14)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Ropivacaine 2 % | 29 |
| acid tranexamic | 25 |
| Pericapsular Nerve Group (PENG) Block | 18 |
| Femoral Nerve Block | 17 |
| PENG Block | 15 |
Showing 5 of 14 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Leg Injuries trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Study Fracture Related Complication | 1,092 | 1 |
| Other | 1,052 | 3 |
| Other serious adverse event | 378 | 1 |
| Pulmonary | 260 | 2 |
| Renal | 201 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Leg Injuries? (252)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Efficacy and acceptability of different blood flow restriction training interventions during the rehabilitation of military personnel with lower limb musculoskeletal injuries: protocol for a two-phase randomised controlled trial. | BMJ open | 2025 | Yes |
| Predictors of Early Return to Sport After Surgical Repair of Proximal Hamstring Complex Injuries in Professional Athletes: A Prospective Study. | The American journal of sports medicine | 2024 | Yes |
| Does the type of lower extremity fracture affect long-term opioid usage? A meta-analysis. | Archives of orthopaedic and trauma surgery | 2024 | Yes |
| Hamstring Injuries: A Paradigm for Return to Play. | Seminars in musculoskeletal radiology | 2024 | Yes |
| Incidence and prevalence of hamstring injuries in field-based team sports: a systematic review and meta-analysis of 5952 injuries from over 7 million exposure hours. | British journal of sports medicine | 2023 | Yes |
Showing 5 of 252 publications.
Sub-conditions in MeSH (7)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.